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| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa) |
| | CTH | Cystathionase (Cystathionine gamma-lyase). (405 aa) |
| | BCL10 | B-cell CLL/lymphoma 10. (316 aa) |
| | LAMTOR5 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa) |
| | CRNN | CRNN isoform 1. (495 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | DHX9 | DEAH (Asp-Glu-Ala-His) box polypeptide 9. (1270 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | NLRP3 | NLRP3 isoform 2. (1025 aa) |
| | TRIM8 | Tripartite motif containing 8. (551 aa) |
| | PRDX3 | PRDX3 isoform 1. (256 aa) |
| | TRIM21 | Tripartite motif containing 21. (475 aa) |
| | TRIM68 | Tripartite motif containing 68. (485 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | RPS6KA4 | Ribosomal protein S6 kinase. (772 aa) |
| | ANKRD42 | Ankyrin repeat domain 42. (527 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (247 aa) |
| | RHEBL1 | Ras homolog enriched in brain like 1. (183 aa) |
| | IRAK3 | Interleukin-1 receptor-associated kinase 3. (595 aa) |
| | NTS | NTS isoform 1. (170 aa) |
| | UBE2N | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | TRIM13 | Tripartite motif containing 13. (410 aa) |
| | RNF31 | T0103527 isoform 1. (1072 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | CIB1 | Calcium and integrin binding 1. (231 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa) |
| | CX3CL1 | Chemokine (C-X3-C motif) ligand 1. (397 aa) |
| | TERF2IP | Telomeric repeat binding factor 2, interacting protein. (399 aa) |
| | DHX33 | DEAH-box helicase 33. (707 aa) |
| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (1004 aa) |
| | MALT1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa) |
| | AMH | Anti-Mullerian hormone. (560 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1620 aa) |
| | IL18R1 | Uncharacterized protein. (440 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (599 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | CK820_G0037244 | NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | IRAK2 | Interleukin-1 receptor-associated kinase 2. (625 aa) |
| | LTF | Lactotransferrin; Belongs to the transferrin family. (711 aa) |
| | ENSPTRP00000026978 | annotation not available (268 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa) |
| | CLOCK | Clock circadian regulator. (847 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TLR3 | Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | TRIML1 | TRIML1 isoform 2. (468 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | RIPK1 | Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa) |
| | NOD1 | Nucleotide-binding oligomerization domain containing 1. (953 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | MTDH | MTDH isoform 1. (582 aa) |
| | TRAPPC9 | Trafficking protein particle complex 9. (1246 aa) |
| | TRIM32 | Tripartite motif-containing 32. (653 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa) |
| | BTK | BTK isoform 2. (693 aa) |
| | IRAK1-2 | Interleukin-1 receptor-associated kinase 1. (712 aa) |
| | MID2 | MID2 isoform 1. (735 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | DDRGK1 | DDRGK domain containing 1. (314 aa) |
| | MTPN | MTPN isoform 1. (118 aa) |
| | TRIM15 | Tripartite motif-containing protein 15; Belongs to the TRIM/RBCC family. (465 aa) |
| | TRIM22 | Tripartite motif containing 22. (498 aa) |
| | TRADD | TNFRSF1A-associated via death domain. (312 aa) |
| | TFRC | Transferrin receptor (P90, CD71). (760 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (153 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (543 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (420 aa) |
| | TRIM52 | TRIM52 isoform 2. (288 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | TRIM62 | Tripartite motif containing 62. (475 aa) |
| | LOC453361 | CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | NPM1-2 | NPM1 isoform 5. (306 aa) |
| | LOC745166 | HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa) |
| | SLCO3A1 | Solute carrier organic anion transporter family member. (714 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (199 aa) |
| | LOC101057058 | 40S ribosomal protein S3 pseudogene. (270 aa) |
| | RPS3 | RPS3 isoform 13; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | CARD16 | Caspase recruitment domain-containing protein 16 isoform X4. (197 aa) |
| | TIRAP | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (235 aa) |
| | TRIM14 | Tripartite motif-containing 14. (442 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (824 aa) |
| | ENSPTRP00000064832 | annotation not available (85 aa) |
| | TRIM37 | Tripartite motif-containing 37. (964 aa) |
| | ENSPTRP00000065244 | annotation not available (463 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | ENSPTRP00000066171 | annotation not available (772 aa) |
| | ENSPTRP00000066329 | annotation not available (241 aa) |
| | LOC743115 | Nucleophosmin pseudogene. (255 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa) |
| | TRIM6 | Tripartite motif containing 6. (841 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (493 aa) |
| | CD40 | CD40 molecule, TNF receptor superfamily member 5. (277 aa) |
| | LOC452606 | ATP-dependent RNA helicase A pseudogene. (350 aa) |
| | NPM1 | NPM1 isoform 1. (294 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1031 aa) |
| | RNF25 | Ring finger protein 25. (476 aa) |
| | ENSPTRP00000070633 | annotation not available (178 aa) |
| | CK820_G0021831 | RPS3 isoform 18; Belongs to the universal ribosomal protein uS3 family. (100 aa) |
| | ENSPTRP00000072507 | annotation not available (659 aa) |
| | ENSPTRP00000074371 | annotation not available (264 aa) |
| | CD36 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa) |
| | LOC737257 | Nucleophosmin pseudogene. (312 aa) |
| | ENSPTRP00000075745 | annotation not available (296 aa) |
| | ENSPTRP00000075929 | annotation not available (130 aa) |
| | TRIML2 | TRIML2 isoform 4. (436 aa) |
| | LOC100610002 | IKBKG isoform 9. (401 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa) |
| | ENSPTRP00000076878 | annotation not available (139 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | CK820_G0040570 | PRKCZ isoform 2. (457 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa) |
| | ENSPTRP00000079686 | annotation not available (213 aa) |
| | UBE2V1 | UBE2V2 isoform 7. (170 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | TNFSF18 | Tumor necrosis factor ligand 2A. (199 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1120 aa) |
| | ENSPTRP00000081523 | annotation not available (174 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | PIDD1 | Leucine-rich repeats and death domain containing. (909 aa) |
| | UBE2N-2 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (687 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | TLR9 | T0016681 isoform 1. (1033 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | CARD11 | Caspase recruitment domain family, member 11. (1154 aa) |
| | ENSPTRP00000085517 | annotation not available (294 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | ENSPTRP00000086173 | annotation not available (566 aa) |
| | PYDC5 | Pyrin domain-only protein 3. (113 aa) |
| | ROR1 | Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (945 aa) |
| | RIPK4 | Receptor interacting serine/threonine kinase 4. (834 aa) |
| | ENSPTRP00000087196 | annotation not available (261 aa) |
| | ENSPTRP00000087988 | annotation not available (165 aa) |
| | LGALS9 | Galectin. (355 aa) |
| | ENSPTRP00000088520 | annotation not available (242 aa) |
| | CK820_G0040570-2 | PRKCZ isoform 4. (95 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (617 aa) |
| | ENSPTRP00000089974 | annotation not available (735 aa) |
| | LOC100614824 | Uncharacterized LOC100614824. (54 aa) |
| | LOC473924 | Peptidylprolyl isomerase A pseudogene. (105 aa) |
| | ITGB2 | Integrin beta. (863 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | ENSPTRP00000091883 | annotation not available (155 aa) |
| | LOC107968189 | Peptidyl-prolyl cis-trans isomerase A pseudogene. (173 aa) |
| | RTKN2 | RTKN2 isoform 1. (609 aa) |
| | CARD9 | Caspase recruitment domain family, member 9. (536 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa) |
