STRINGSTRING
LOC467485 LOC467485 MED28 MED28 BCL2 BCL2 ENSPTRP00000090304 ENSPTRP00000090304 FRS2 FRS2 EZH2-2 EZH2-2 MEF2C MEF2C SHOX2 SHOX2 NRG1 NRG1 CK820_G0048817 CK820_G0048817 PLPP7 PLPP7 RBM38 RBM38 FOXO4 FOXO4 MAML1 MAML1 MSX1 MSX1 MAPK12 MAPK12 PROX1 PROX1 WNT3A WNT3A TARBP2 TARBP2 NIBAN2 NIBAN2 BMPR2 BMPR2 PI16 PI16 SRF SRF AKIRIN2 AKIRIN2 HEY2 HEY2 LAMA2 LAMA2 DLL1 DLL1 HDAC9 HDAC9 BHLHA15 BHLHA15 CCN3 CCN3 TRIM32 TRIM32 CDK9 CDK9 ENG ENG NOTCH1 NOTCH1 G6PD G6PD MAMSTR MAMSTR CCNT2 CCNT2 SOX6 SOX6 MYOG MYOG NFATC2 NFATC2 MTOR MTOR CTH CTH OR10J5 OR10J5 RGS4 RGS4 LAMC1 LAMC1 RGS2 RGS2 NID1 NID1 DKK1 DKK1 SIRT1 SIRT1 BMPR1A BMPR1A FGFR2 FGFR2 MYOD1 MYOD1 EFEMP2 EFEMP2 BHLHE41 BHLHE41 MYF6 MYF6 MYF5 MYF5 FGF9 FGF9 EFNB2 EFNB2 PARP2 PARP2 MMP14 MMP14 AKAP6 AKAP6 BMP4 BMP4 SETD3 SETD3 YY1 YY1 RBPMS2 RBPMS2 FBXO22 FBXO22 MESP1 MESP1 TRIM72 TRIM72 MYLK3 MYLK3 PIEZO1 PIEZO1 ARRB2 ARRB2 MYOCD MYOCD SUPT6H SUPT6H KAT2A KAT2A HDAC5 HDAC5 SMAD4 SMAD4 CTDP1 CTDP1 HAMP HAMP TGFB1 TGFB1 GSK3A GSK3A ID2 ID2 TCF23 TCF23 CCDC142 CCDC142 SMYD1 SMYD1 BMP2 BMP2 RBM24 RBM24 TBX1 TBX1 PDGFB PDGFB PPARA PPARA CAV3 CAV3 LAMB2 LAMB2 LMOD3 LMOD3 TOMM70 TOMM70 KIT KIT ANKRD17 ANKRD17 EREG EREG SMAD1 SMAD1 NLN NLN PRDM6 PRDM6 MEGF10 MEGF10 NKX2-5 NKX2-5 EDN1 EDN1 MAPK14 MAPK14 SIRT1-2 SIRT1-2 CK820_G0025516 CK820_G0025516 ZEB1 ZEB1 CK820_G0054728 CK820_G0054728 ENSPTRP00000064416 ENSPTRP00000064416 CK820_G0046635 CK820_G0046635 NFATC1 NFATC1 XBP1 XBP1 HOPX HOPX DNMT1 DNMT1 LOC747903 LOC747903 IGF1 IGF1 DMPK DMPK BHLHA15-2 BHLHA15-2 TMEM119 TMEM119 ZBED6CL ZBED6CL HDAC4 HDAC4 ENSPTRP00000074270 ENSPTRP00000074270 MAPK11 MAPK11 LOC104004819 LOC104004819 FOXP1 FOXP1 SHH SHH ENSPTRP00000076001 ENSPTRP00000076001 YBX1 YBX1 PTBP1 PTBP1 ENSPTRP00000076468 ENSPTRP00000076468 EZH2 EZH2 BMP10 BMP10 ENSPTRP00000078565 ENSPTRP00000078565 LOC452975 LOC452975 IGF2 IGF2 PDCD4 PDCD4 CYP26B1 CYP26B1 BMP4-2 BMP4-2 MECP2 MECP2 OLFM2 OLFM2 SOD2 SOD2 ENSPTRP00000084090 ENSPTRP00000084090 ENSPTRP00000084126 ENSPTRP00000084126 ENSPTRP00000084510 ENSPTRP00000084510 LAMA1 LAMA1 DNMT1-2 DNMT1-2 CAMK1 CAMK1 ACTN3 ACTN3 NFATC3 NFATC3 ATP11A ATP11A FZD7 FZD7
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC467485Polypyrimidine tract-binding protein 1-like. (488 aa)
MED28Mediator complex subunit 28. (178 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000090304annotation not available (236 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SHOX2SHOX2 isoform 2. (343 aa)
NRG1NRG1 isoform 3. (713 aa)
CK820_G0048817RBM38 isoform 2. (182 aa)
PLPP7Phosphatidic acid phosphatase type 2 domain containing 3. (271 aa)
RBM38RNA binding motif protein 38. (207 aa)
FOXO4Forkhead box O4. (505 aa)
MAML1MAML1 isoform 1. (1016 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
PROX1Prospero homeobox 1. (737 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
NIBAN2FAM129B isoform 2. (746 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
PI16PI16 isoform 1; Belongs to the CRISP family. (465 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
AKIRIN2AKIRIN2 isoform 1. (203 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
CCN3NOV isoform 1. (357 aa)
TRIM32Tripartite motif-containing 32. (653 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
MAMSTRMAMSTR isoform 1. (312 aa)
CCNT2CCNT2 isoform 4; Belongs to the cyclin family. (730 aa)
SOX6SOX6 isoform 9. (828 aa)
MYOGMYOG isoform 1. (249 aa)
NFATC2NFATC2 isoform 4. (938 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CTHCystathionase (Cystathionine gamma-lyase). (405 aa)
OR10J5Olfactory receptor family 10 subfamily J member 5. (309 aa)
RGS4Regulator of G protein signaling 4. (302 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
RGS2Regulator of G-protein signaling 2, 24kDa. (211 aa)
NID1NID1 isoform 2. (1247 aa)
DKK1Dickkopf-like protein 1. (289 aa)
SIRT1SIRT1 isoform 2. (751 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
EFEMP2EGF containing fibulin-like extracellular matrix protein 2. (443 aa)
BHLHE41Basic helix-loop-helix family member e41. (482 aa)
MYF6Myogenic factor 6. (242 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SETD3Protein-histidine N-methyltransferase. (594 aa)
YY1YY1 transcription factor. (414 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
FBXO22F-box protein 22. (403 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
TRIM72Tripartite motif containing 72. (477 aa)
MYLK3MYLK3 isoform 1. (819 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2516 aa)
ARRB2ARRB2 isoform 2. (430 aa)
MYOCDMYOCD isoform 2. (986 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
TCF23Transcription factor 23. (214 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
RBM24RNA binding motif protein 24. (254 aa)
TBX1TBX1 isoform 1. (478 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
LMOD3LMOD3 isoform 1. (560 aa)
TOMM70Translocase of outer mitochondrial membrane 70 homolog A. (608 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
ANKRD17Ankyrin repeat domain 17. (2603 aa)
EREGEREG isoform 1. (169 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
NLNNeurolysin (Metallopeptidase M3 family). (704 aa)
PRDM6PR/SET domain 6. (594 aa)
MEGF10MEGF10 isoform 2. (1140 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
EDN1EDN1 isoform 1. (212 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
SIRT1-2Sirtuin 1. (751 aa)
CK820_G0025516YBX1 isoform 1. (320 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
ENSPTRP00000064416annotation not available (502 aa)
CK820_G0046635NACA isoform 1. (1839 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. (853 aa)
XBP1XBP1 isoform 4. (381 aa)
HOPXHOPX isoform 3. (112 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa)
LOC747903Nuclease-sensitive element-binding protein 1 pseudogene. (306 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
DMPKDystrophia myotonica-protein kinase. (639 aa)
BHLHA15-2Basic helix-loop-helix family member a15. (189 aa)
TMEM119Transmembrane protein 119. (283 aa)
ZBED6CLChromosome 7 open reading frame 29. (236 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
ENSPTRP00000074270annotation not available (297 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LOC104004819Nuclease-sensitive element-binding protein 1 pseudogene. (315 aa)
FOXP1FOXP1 isoform 2. (693 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000076001annotation not available (125 aa)
YBX1YBX1 isoform 3. (295 aa)
PTBP1PTBP1 isoform 2. (680 aa)
ENSPTRP00000076468annotation not available (140 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPTRP00000078565annotation not available (328 aa)
LOC452975Nuclease-sensitive element-binding protein 1 pseudogene. (328 aa)
IGF2Insulin like growth factor 2. (236 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
OLFM2OLFM2 isoform 1. (478 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
ENSPTRP00000084090annotation not available (121 aa)
ENSPTRP00000084126annotation not available (117 aa)
ENSPTRP00000084510annotation not available (456 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
DNMT1-2DNA methyltransferase 1. (1674 aa)
CAMK1Calcium/calmodulin-dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1191 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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