43 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
	MYF6	Myogenic factor 6. (242 aa)
	EFNB2	EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
	PARP2	Poly [ADP-ribose] polymerase. (570 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	AKAP6	A-kinase anchoring protein 6. (2319 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	MYLK3	MYLK3 isoform 1. (819 aa)
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2516 aa)
	ARRB2	ARRB2 isoform 2. (430 aa)
	MYOCD	MYOCD isoform 2. (986 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	KAT2A	Histone acetyltransferase KAT2A isoform X1. (837 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SMYD1	SET and MYND domain containing 1. (490 aa)
	RBM24	RNA binding motif protein 24. (254 aa)
	TBX1	TBX1 isoform 1. (478 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LMOD3	LMOD3 isoform 1. (560 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	MAPK14	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
	TRIM32	Tripartite motif-containing 32. (653 aa)
	MAMSTR	MAMSTR isoform 1. (312 aa)
	MYOG	MYOG isoform 1. (249 aa)
	NIBAN2	FAM129B isoform 2. (746 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	HOPX	HOPX isoform 3. (112 aa)
	IGF1	Insulin-like growth factor 1 (Somatomedin C). (196 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (944 aa)
	ATP11A	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1191 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	SHOX2	SHOX2 isoform 2. (343 aa)
	NRG1	NRG1 isoform 3. (713 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	MYF6	ENSPTRP00000086020	ENSPTRP00000008936	Actinin alpha 3 (gene/pseudogene).	Myogenic factor 6.	0.453
AKAP6	CAV3	ENSPTRP00000010600	ENSPTRP00000025136	A-kinase anchoring protein 6.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.426
ARRB2	CAV3	ENSPTRP00000014687	ENSPTRP00000025136	ARRB2 isoform 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.501
ARRB2	SHH	ENSPTRP00000014687	ENSPTRP00000075730	ARRB2 isoform 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.403
ARRB2	TGFB1	ENSPTRP00000014687	ENSPTRP00000018930	ARRB2 isoform 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.498
BCL2	IGF1	ENSPTRP00000090293	ENSPTRP00000067917	BCL2 apoptosis regulator.	Insulin-like growth factor 1 (Somatomedin C).	0.630
BCL2	MAPK14	ENSPTRP00000090293	ENSPTRP00000030915	BCL2 apoptosis regulator.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.546
BCL2	MTOR	ENSPTRP00000090293	ENSPTRP00000000280	BCL2 apoptosis regulator.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.595
BCL2	TGFB1	ENSPTRP00000090293	ENSPTRP00000018930	BCL2 apoptosis regulator.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.509
BMP10	BMP4	ENSPTRP00000078228	ENSPTRP00000010780	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.505
BMP10	BMP4-2	ENSPTRP00000078228	ENSPTRP00000080656	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.505
BMP4	BMP10	ENSPTRP00000010780	ENSPTRP00000078228	Bone morphogenetic protein 4.	Bone morphogenetic protein 10.	0.505
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4	WNT3A	ENSPTRP00000010780	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
BMP4-2	BMP10	ENSPTRP00000080656	ENSPTRP00000078228	Bone morphogenetic protein 4.	Bone morphogenetic protein 10.	0.505
BMP4-2	SHH	ENSPTRP00000080656	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4-2	WNT3A	ENSPTRP00000080656	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
CAV3	AKAP6	ENSPTRP00000025136	ENSPTRP00000010600	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	A-kinase anchoring protein 6.	0.426
CAV3	ARRB2	ENSPTRP00000025136	ENSPTRP00000014687	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	ARRB2 isoform 2.	0.501
CAV3	MYOG	ENSPTRP00000025136	ENSPTRP00000044084	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	MYOG isoform 1.	0.429