STRINGSTRING
CK820_G0045089 CK820_G0045089 ITGB8-2 ITGB8-2 FGF6 FGF6 TRPV4 TRPV4 WNT5A WNT5A PBXIP1 PBXIP1 HOXD3 HOXD3 ENSPTRP00000088770 ENSPTRP00000088770 COL11A1 COL11A1 FGFR3 FGFR3 ENSPTRP00000089565 ENSPTRP00000089565 OSR2 OSR2 RUNX1 RUNX1 ENSPTRP00000092702 ENSPTRP00000092702 CHST11 CHST11 SHOX2 SHOX2 FGF18 FGF18 CD44 CD44 MGP MGP MEF2C MEF2C ENSPTRP00000089584 ENSPTRP00000089584 CCN2 CCN2 RUNX3 RUNX3 MATN1 MATN1 ENSPTRP00000000998 ENSPTRP00000000998 BMP8B BMP8B CCN1 CCN1 ECM1 ECM1 THBS3 THBS3 PRRX1 PRRX1 CHI3L1 CHI3L1 BMPR1A BMPR1A ESRRA ESRRA LTBP3 LTBP3 BBS1 BBS1 FGF4 FGF4 SERPINH1 SERPINH1 ZBTB16 ZBTB16 BARX2 BARX2 SNX19 SNX19 WNT5B WNT5B SOX5 SOX5 WNT10B WNT10B MYF5 MYF5 EPYC EPYC FGF9 FGF9 RB1 RB1 CNMD CNMD BMP4 BMP4 HIF1A HIF1A TRIP11 TRIP11 ADAMTS7 ADAMTS7 BBS2 BBS2 SMPD3 SMPD3 THRA THRA COL1A1 COL1A1 NOG NOG AXIN2 AXIN2 SOX9 SOX9 TYMS TYMS TWSG1 TWSG1 MEX3C MEX3C TGFB1 TGFB1 OSR1 OSR1 MATN3 MATN3 SIX2 SIX2 EIF2AK3 EIF2AK3 ARID5A ARID5A DLX2 DLX2 COL3A1 COL3A1 IHH IHH NPPC NPPC BMP2 BMP2 MKKS MKKS GDF5 GDF5 BMP7 BMP7 CBS CBS PTH1R PTH1R HYAL3 HYAL3 HYAL1 HYAL1 MUSTN1 MUSTN1 IFT80 IFT80 CYTL1 CYTL1 BMP3 BMP3 BMPR1B BMPR1B SMAD1 SMAD1 SFRP2 SFRP2 PITX1 PITX1 HAND1 HAND1 BMP6 BMP6 EDN1 EDN1 GPLD1 GPLD1 MAPK14 MAPK14 SRF SRF IL17F IL17F BMP5 BMP5 HOXA5 HOXA5 HOXA11 HOXA11 GLI3 GLI3 CREB3L2 CREB3L2 BMP1 BMP1 STC1 STC1 SNAI2 SNAI2 EXT1 EXT1 CCN3 CCN3 CER1 CER1 OGN OGN COL27A1 COL27A1 HES5 HES5 COL2A1 COL2A1 BGN BGN SOX6 SOX6 DDRGK1 DDRGK1 CTNNB1 CTNNB1 HYAL2 HYAL2 TSKU TSKU BMPR2 BMPR2 HAND2 HAND2 HMGA2 HMGA2 OTOR OTOR RARA RARA MAPK3 MAPK3 EVC EVC WNT2B WNT2B MSX1 MSX1 TAPT1 TAPT1 AMELX AMELX COMP COMP NFIB NFIB ADAMTS12 ADAMTS12 ENSPTRP00000062696 ENSPTRP00000062696 ZEB1 ZEB1 HOXB3 HOXB3 LOC104003639 LOC104003639 WNT7B WNT7B ATF2 ATF2 RSPO2 RSPO2 SLC39A14 SLC39A14 ATP7A ATP7A ENSPTRP00000064416 ENSPTRP00000064416 CK820_G0056924 CK820_G0056924 UNCX UNCX WNT7A WNT7A SNORC SNORC TGFBI TGFBI RUNX2 RUNX2 SNAI1 SNAI1 HOXA3 HOXA3 COL11A2 COL11A2 GDF2 GDF2 CHRDL2 CHRDL2 HOXA3-2 HOXA3-2 IMPAD1 IMPAD1 ENSPTRP00000073126 ENSPTRP00000073126 SCX SCX SULF1 SULF1 HOXC4 HOXC4 MEF2D MEF2D GHR GHR TGFBR2 TGFBR2 MMP13 MMP13 ENSPTRP00000077036 ENSPTRP00000077036 ENSPTRP00000077262 ENSPTRP00000077262 GHRL GHRL LOC100612565 LOC100612565 ACCS ACCS ENSPTRP00000079262 ENSPTRP00000079262 SMAD5 SMAD5 SATB2 SATB2 ZMPSTE24 ZMPSTE24 ENSPTRP00000080279 ENSPTRP00000080279 HES5-2 HES5-2 BMP4-2 BMP4-2 ANXA6 ANXA6 TIMP1 TIMP1 SULF2 SULF2 ITGB8 ITGB8 RARB RARB RARG RARG SCUBE2 SCUBE2 CK820_G0054628 CK820_G0054628
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CK820_G0045089RANBP3 isoform 23. (97 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PBXIP1Pre-B-cell leukemia homeobox interacting protein 1. (731 aa)
HOXD3HOXD3 isoform 3. (432 aa)
ENSPTRP00000088770annotation not available (124 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
ENSPTRP00000089565annotation not available (801 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSPTRP00000092702annotation not available (482 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
SHOX2SHOX2 isoform 2. (343 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CD44CD44 isoform 3. (742 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSPTRP00000089584annotation not available (842 aa)
CCN2CTGF isoform 1. (349 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
MATN1MATN1 isoform 1. (496 aa)
ENSPTRP00000000998annotation not available (224 aa)
BMP8BBMP8B isoform 1. (402 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ECM1Extracellular matrix protein 1. (540 aa)
THBS3Thrombospondin 3. (956 aa)
PRRX1Paired related homeobox 1. (245 aa)
CHI3L1Chitinase 3-like 1 (Cartilage glycoprotein-39); Belongs to the glycosyl hydrolase 18 family. (383 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SERPINH1Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1); Belongs to the serpin family. (418 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
BARX2BARX homeobox 2. (279 aa)
SNX19Sorting nexin 19. (992 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SOX5SRY (Sex determining region Y)-box 5. (765 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
EPYCEPYC isoform 1. (322 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RB1RB transcriptional corepressor 1. (928 aa)
CNMDCNMD isoform 4. (334 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
ADAMTS7ADAMTS7 isoform 1. (932 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
THRAThyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian). (617 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TYMSThymidylate synthetase. (313 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
MEX3CMEX3C isoform 2. (639 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MATN3MATN3 isoform 1. (486 aa)
SIX2SIX homeobox 2. (291 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
ARID5AAT rich interactive domain 5A (MRF1-like). (594 aa)
DLX2Distal-less homeobox 2. (328 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NPPCNatriuretic peptide C. (126 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
HYAL3Hyaluronidase-3 precursor. (417 aa)
HYAL1Hyaluronidase. (435 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1 isoform X1. (87 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
CYTL1CYTL1 isoform 1. (136 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
PITX1Homeobox protein. (314 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
EDN1EDN1 isoform 1. (212 aa)
GPLD1GPLD1 isoform 2. (840 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
IL17FIL17F isoform 1. (199 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
HOXA5HOXA5 isoform 1. (270 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
BMP1Metalloendopeptidase. (986 aa)
STC1Stanniocalcin 1. (247 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CCN3NOV isoform 1. (357 aa)
CER1CER1 isoform 1. (267 aa)
OGNOGN isoform 2. (298 aa)
COL27A1COL27A1 isoform 1. (1860 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (376 aa)
SOX6SOX6 isoform 9. (828 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HYAL2Hyaluronidase. (473 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
OTOROTOR isoform 1. (128 aa)
RARARARA isoform 4. (624 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EVCEVC isoform 1. (991 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
AMELXAmelogenin X-linked. (205 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
ENSPTRP00000062696annotation not available (320 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
HOXB3HOXB3 isoform 13. (431 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RSPO2R-spondin 2 homolog. (243 aa)
SLC39A14SLC39A14 isoform 1. (490 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
ENSPTRP00000064416annotation not available (502 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
UNCXUNCX isoform 1. (531 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (121 aa)
TGFBITransforming growth factor, beta-induced, 68kDa. (706 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HOXA3HOXA3 isoform 3. (443 aa)
COL11A2COL11A2 isoform 2. (1736 aa)
GDF2GDF2 isoform 1. (429 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
HOXA3-2Homeobox A3. (443 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
ENSPTRP00000073126annotation not available (296 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
HOXC4HOXC4 isoform 1. (264 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
GHRGrowth hormone receptor. (645 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
MMP13Matrix metallopeptidase 13. (498 aa)
ENSPTRP00000077036annotation not available (396 aa)
ENSPTRP00000077262annotation not available (314 aa)
GHRLGHRL isoform 10. (117 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
ENSPTRP00000079262annotation not available (866 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SATB2DNA-binding protein SATB. (733 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
ENSPTRP00000080279annotation not available (270 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ANXA6Annexin. (788 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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