STRINGSTRING
LOC459638 LOC459638 ENSPTRP00000093582 ENSPTRP00000093582 ABL2 ABL2 LOC739615 LOC739615 ENSPTRP00000092364 ENSPTRP00000092364 SOCS3 SOCS3 SCAF8 SCAF8 SNCA SNCA PCIF1 PCIF1 YES1 YES1 ENSPTRP00000090501 ENSPTRP00000090501 ENSPTRP00000089974 ENSPTRP00000089974 ENSPTRP00000089450 ENSPTRP00000089450 ENSPTRP00000088766 ENSPTRP00000088766 ENSPTRP00000088582 ENSPTRP00000088582 ENSPTRP00000088414 ENSPTRP00000088414 SH3BP2 SH3BP2 ENSPTRP00000086548 ENSPTRP00000086548 NEDD4 NEDD4 CBLC CBLC LOC473133 LOC473133 VAV2 VAV2 CRK CRK BCAR3 BCAR3 APTX APTX ENSPTRP00000082446 ENSPTRP00000082446 ENSPTRP00000081955 ENSPTRP00000081955 ENSPTRP00000081537 ENSPTRP00000081537 ENSPTRP00000081300 ENSPTRP00000081300 TOX3 TOX3 PHF6 PHF6 PAFAH1B1 PAFAH1B1 MID1 MID1 ENSPTRP00000077211 ENSPTRP00000077211 BTRC BTRC PIK3R1 PIK3R1 SRC SRC PLCG2 PLCG2 ENSPTRP00000075494 ENSPTRP00000075494 SYK SYK CK820_G0050194 CK820_G0050194 ENSPTRP00000074763 ENSPTRP00000074763 PTPN11-2 PTPN11-2 ABL1 ABL1 ENSPTRP00000070303 ENSPTRP00000070303 UBASH3B UBASH3B PTPN3 PTPN3 ENSPTRP00000068968 ENSPTRP00000068968 ENSPTRP00000067174 ENSPTRP00000067174 PIK3R3 PIK3R3 FBXW9 FBXW9 SHC3 SHC3 IGF2R IGF2R CK820_G0012168 CK820_G0012168 PTPN11 PTPN11 CBX4 CBX4 SFN SFN MAPK3 MAPK3 YWHAB YWHAB SHC1 SHC1 PTPN6 PTPN6 SHB SHB URI1 URI1 CRKL CRKL LYN LYN MID2 MID2 EPB41 EPB41 ARR3 ARR3 SH2D3C SH2D3C RRAGA RRAGA DPYS DPYS PLAT PLAT TBL2 TBL2 LRP11 LRP11 RASA1 RASA1 FBXW7 FBXW7 PITX2 PITX2 PKD2 PKD2 STAP1 STAP1 CBLB CBLB GRAP2 GRAP2 MAPK1 MAPK1 UBASH3A UBASH3A SCAF4 SCAF4 SAMSN1 SAMSN1 HCK HCK SAG SAG IRS1 IRS1 NCK2 NCK2 ZAP70 ZAP70 PIH1D1 PIH1D1 PIK3R2 PIK3R2 PRKCSH PRKCSH PIN1 PIN1 VAV1 VAV1 SH2D3A SH2D3A SHD SHD GRB2 GRB2 PFN1 PFN1 TRPV1 TRPV1 YWHAE YWHAE LEO1 LEO1 SHF SHF RTF1 RTF1 RB1 RB1 TBK1 TBK1 FKBP4 FKBP4 CBL CBL BBS1 BBS1 MEN1 MEN1 PTPN5 PTPN5 SHE SHE THRAP3 THRAP3 LCK LCK FGR FGR LDLRAP1 LDLRAP1 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000093582annotation not available (368 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
LOC739615Peptidyl-prolyl cis-trans isomerase FKBP4 pseudogene. (398 aa)
ENSPTRP00000092364annotation not available (574 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SCAF8SR-related CTD associated factor 8. (1352 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (815 aa)
YES1Tyrosine-protein kinase. (558 aa)
ENSPTRP00000090501annotation not available (192 aa)
ENSPTRP00000089974annotation not available (735 aa)
ENSPTRP00000089450annotation not available (303 aa)
ENSPTRP00000088766annotation not available (199 aa)
ENSPTRP00000088582annotation not available (66 aa)
ENSPTRP00000088414annotation not available (529 aa)
SH3BP2SH3 domain binding protein 2. (618 aa)
ENSPTRP00000086548annotation not available (433 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
CBLCCbl proto-oncogene C. (474 aa)
LOC473133Peptidyl-prolyl cis-trans isomerase FKBP4 pseudogene. (175 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
BCAR3Breast cancer anti-estrogen resistance 3. (825 aa)
APTXAPTX isoform 14. (354 aa)
ENSPTRP00000082446annotation not available (194 aa)
ENSPTRP00000081955annotation not available (66 aa)
ENSPTRP00000081537annotation not available (449 aa)
ENSPTRP00000081300annotation not available (154 aa)
TOX3TOX high mobility group box family member 3. (589 aa)
PHF6PHD finger protein 6. (366 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
MID1MID1 isoform 1. (663 aa)
ENSPTRP00000077211annotation not available (269 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SRCTyrosine-protein kinase. (542 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSPTRP00000075494annotation not available (194 aa)
SYKTyrosine-protein kinase. (635 aa)
CK820_G0050194GRAP isoform 1. (153 aa)
ENSPTRP00000074763annotation not available (520 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSPTRP00000070303annotation not available (117 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa)
ENSPTRP00000068968annotation not available (60 aa)
ENSPTRP00000067174annotation not available (502 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
SHC3SHC3 isoform 2. (598 aa)
IGF2RIGF2R isoform 2. (2491 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CBX4CBX4 isoform 1. (560 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SHBSrc homology 2 domain containing adaptor protein B. (509 aa)
URI1Chromosome 19 open reading frame 2. (537 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
LYNTyrosine-protein kinase. (512 aa)
MID2MID2 isoform 1. (735 aa)
EPB41Erythrocyte membrane protein band 4.1. (864 aa)
ARR3ARR3 isoform 1. (388 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
RRAGARas-related GTP binding A. (341 aa)
DPYSDihydropyrimidinase. (519 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
TBL2Transducin (Beta)-like 2. (447 aa)
LRP11Low density lipoprotein receptor-related protein 11. (500 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
PITX2Homeobox protein. (324 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
UBASH3AUbiquitin associated and SH3 domain containing A. (661 aa)
SCAF4SR-related CTD-associated factor 4. (1147 aa)
SAMSN1SAM domain-containing protein SAMSN-1 isoform X1. (441 aa)
HCKTyrosine-protein kinase. (526 aa)
SAGS-antigen visual arrestin. (405 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
NCK2Cytoplasmic protein. (380 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
PIH1D1PIH1 domain containing 1. (321 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCSHProtein kinase C substrate 80K-H. (535 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
SHFSrc homology 2 domain containing F. (423 aa)
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
RB1RB transcriptional corepressor 1. (928 aa)
TBK1TANK-binding kinase 1. (729 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
MEN1MEN1 isoform 14. (615 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (565 aa)
SHESrc homology 2 domain containing E. (495 aa)
THRAP3Thyroid hormone receptor associated protein 3. (955 aa)
LCKTyrosine-protein kinase. (539 aa)
FGRTyrosine-protein kinase. (529 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.