STRINGSTRING
CASQ2 CASQ2 CALM1 CALM1 ENSPTRP00000082718 ENSPTRP00000082718 ATP1A2 ATP1A2 SRI-2 SRI-2 ANXA6 ANXA6 SRI SRI CD19 CD19 LOC745935 LOC745935 PLCG2 PLCG2 PLN PLN BBC3 BBC3 DIAPH1 DIAPH1 ERO1A ERO1A NOL3 NOL3 ABL1 ABL1 GP5 GP5 UBASH3B UBASH3B DMD DMD ITGB3 ITGB3 TRPM2 TRPM2 PDE4D PDE4D CLIC2-2 CLIC2-2 DRD1 DRD1 HTT HTT RYR2 RYR2 SLC8A1 SLC8A1 ENSPTRP00000063671 ENSPTRP00000063671 FLNA FLNA GSTO1 GSTO1 JPH2 JPH2 TPCN2 TPCN2 ENSPTRP00000061732 ENSPTRP00000061732 CK820_G0012168 CK820_G0012168 LIME1 LIME1 GP9 GP9 JPH4 JPH4 TRDN TRDN GP1BB GP1BB CCL3 CCL3 CK820_G0015936 CK820_G0015936 LOC453361 LOC453361 JPH3 JPH3 GP1BA GP1BA ASPH ASPH JPH1 JPH1 CCR7 CCR7 BDKRB1 BDKRB1 MCOLN2 MCOLN2 XCR1 XCR1 PTPN6 PTPN6 P2RX7 P2RX7 F2RL3 F2RL3 NPSR1 NPSR1 CLIC2 CLIC2 TRPA1 TRPA1 LYN LYN ANK2 ANK2 DDIT3 DDIT3 HTR2C HTR2C CXCR3 CXCR3 CCL21 CCL21 CCL19 CCL19 CHD7 CHD7 PTK2B PTK2B ATG5 ATG5 IBTK IBTK ITPR3 ITPR3 F2R F2R PKD2 PKD2 CXCL11 CXCL11 CXCL10 CXCL10 CXCL9 CXCL9 LETM1 LETM1 CCR5 CCR5 ITPR1 ITPR1 ITPR2 ITPR2 CK820_G0037244 CK820_G0037244 PLCG1 PLCG1 HTR2B HTR2B LHCGR LHCGR PRKCE PRKCE FKBP1B FKBP1B HRC HRC CALM3 CALM3 TGFB1 TGFB1 TMEM38A TMEM38A CHERP CHERP PRKACA PRKACA MCOLN1 MCOLN1 SLC25A23 SLC25A23 JSRP1 JSRP1 HAP1 HAP1 DHRS7C DHRS7C TRPV1 TRPV1 CX3CL1 CX3CL1 CORO1A CORO1A CEMIP CEMIP AKAP6 AKAP6 PRKD1 PRKD1 RASA3 RASA3 METTL21C METTL21C HTR2A HTR2A SLC8B1 SLC8B1 TPCN1 TPCN1 LACRT LACRT CACNA1C CACNA1C THY1 THY1 P2RY6 P2RY6 APLNR APLNR F2 F2 PTPRC PTPRC FASLG FASLG LCK LCK MCOLN3 MCOLN3 CASQ1 CASQ1 BAX BAX CK820_G0029100 CK820_G0029100 RYR1 RYR1 NOS1 NOS1 CYBA CYBA RYR3 RYR3 SNCA SNCA CK820_G0030361 CK820_G0030361 ENSPTRP00000090392 ENSPTRP00000090392 PDPK1 PDPK1 CAMK2D CAMK2D TMEM38B TMEM38B MTLN MTLN ENSPTRP00000086760 ENSPTRP00000086760 ENSPTRP00000086540 ENSPTRP00000086540 SELENON SELENON ENSPTRP00000085680 ENSPTRP00000085680 DMD-2 DMD-2 TRPC1 TRPC1 BBC3-2 BBC3-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
ENSPTRP00000082718annotation not available (235 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
SRI-2SRI isoform 5. (237 aa)
ANXA6Annexin. (788 aa)
SRISRI isoform 1. (205 aa)
CD19CD19 isoform 1. (557 aa)
LOC745935C-C motif chemokine. (87 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
BBC3BCL2 binding component 3. (270 aa)
DIAPH1DIAPH1 isoform 4. (1278 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
NOL3Nucleolar protein 3. (219 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
GP5GP5 isoform 1. (560 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
DMDDMD isoform 3. (3685 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
PDE4DPhosphodiesterase. (809 aa)
CLIC2-2Chloride intracellular channel 2. (247 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
HTTHTT isoform 1. (3131 aa)
RYR2RYR2 isoform 1. (4941 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ENSPTRP00000063671annotation not available (122 aa)
FLNAFLNA isoform 8. (2711 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (696 aa)
TPCN2Two pore segment channel 2. (752 aa)
ENSPTRP00000061732annotation not available (285 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
LIME1Lck-interacting transmembrane adapter 1 isoform X1. (291 aa)
GP9Glycoprotein IX platelet. (177 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
TRDNTRDN isoform 1. (730 aa)
GP1BBGlycoprotein Ib (Platelet), beta polypeptide. (206 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
LOC453361CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
GP1BAGP1BA isoform 1. (653 aa)
ASPHASPH isoform 1. (762 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
BDKRB1Bradykinin receptor B1. (284 aa)
MCOLN2MCOLN2 isoform 1. (566 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
LYNTyrosine-protein kinase. (512 aa)
ANK2ANK2 isoform 1. (3957 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
HTR2C5-hydroxytryptamine receptor 2C; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathway [...] (458 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
CCL19C-C motif chemokine. (98 aa)
CHD7CHD7 isoform 1. (2997 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IBTKInhibitor of Bruton agammaglobulinemia tyrosine kinase. (1353 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
F2RCoagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL10C-X-C motif chemokine. (96 aa)
CXCL9C-X-C motif chemokine. (125 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (741 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
CK820_G0037244NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
HRCHRC isoform 2. (693 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (917 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
MCOLN1MCOLN1 isoform 1. (601 aa)
SLC25A23Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (331 aa)
HAP1HAP1 isoform 2. (667 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
RASA3RAS p21 protein activator 3. (740 aa)
METTL21CMETTL21C isoform 1. (284 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
SLC8B1Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 6; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
TPCN1TPCN1 isoform 2. (888 aa)
LACRTLACRT isoform 3. (137 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
THY1Thy-1 cell surface antigen. (161 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
LCKTyrosine-protein kinase. (539 aa)
MCOLN3MCOLN3 isoform 1. (553 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
BAXBAX isoform 7. (123 aa)
CK820_G0029100SRI isoform 2. (98 aa)
RYR1RYR1 isoform 3. (5037 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
CYBACytochrome b-245 alpha chain. (210 aa)
RYR3Ryanodine receptor 3. (4873 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
ENSPTRP00000090392annotation not available (93 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
TMEM38BTransmembrane protein 38B. (297 aa)
MTLNLINC00116 isoform 1. (139 aa)
ENSPTRP00000086760annotation not available (458 aa)
ENSPTRP00000086540annotation not available (211 aa)
SELENONT0161445 isoform 2. (581 aa)
ENSPTRP00000085680annotation not available (88 aa)
DMD-2Dystrophin. (643 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
BBC3-2BCL2 binding component 3. (270 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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