STRINGSTRING
TRPC7 TRPC7 HCRTR2 HCRTR2 GRM1 GRM1 TRPC6 TRPC6 GRM5 GRM5 F2 F2 SLC35G1 SLC35G1 ITPR1 ITPR1 SLC8B1 SLC8B1 CAV1 CAV1 CALB1 CALB1 TMEM64 TMEM64 TRPC5 TRPC5 TSPOAP1 TSPOAP1 ATP2B1 ATP2B1 TRPC4 TRPC4 FZD9 FZD9 TRPC3 TRPC3 P2RY4 P2RY4 LOC100614689 LOC100614689 CAV2 CAV2 CDH23 CDH23 LOC737549 LOC737549 CALCA CALCA SLC8A1 SLC8A1 RYR2 RYR2 ATP2B3 ATP2B3 ATP2B4 ATP2B4 SCGN SCGN MYH7B MYH7B CALB2 CALB2 ENSPTRP00000075494 ENSPTRP00000075494 PLN PLN ADCY8 ADCY8 GPR3 GPR3 HCRTR1 HCRTR1 CK820_G0057017 CK820_G0057017 ENSPTRP00000082446 ENSPTRP00000082446 TRPC1 TRPC1 CALCB CALCB LOC459638 LOC459638 WNT5A WNT5A ATP2B2 ATP2B2 TUNAR TUNAR ENSPTRP00000088766 ENSPTRP00000088766 ENSPTRP00000090501 ENSPTRP00000090501 CK820_G0030361 CK820_G0030361 GRIA1 GRIA1 RYR1 RYR1 SLC8A2 SLC8A2 YWHAE YWHAE P2RX1 P2RX1 PRKACA PRKACA HRC HRC FKBP1B FKBP1B TMEM178A TMEM178A CAV3 CAV3 P2RY1 P2RY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
GRM1Glutamate receptor, metabotropic 1. (1194 aa)
TRPC6Transient receptor potential cation channel, subfamily C, member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
SLC35G1Solute carrier family 35 member G1. (365 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
SLC8B1Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 6; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CALB1CALB1 isoform 3. (261 aa)
TMEM64Transmembrane protein 64. (380 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
TSPOAP1TSPO associated protein 1. (1867 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
CDH23CDH23 isoform 1. (3359 aa)
LOC737549Battenin. (418 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RYR2RYR2 isoform 1. (4941 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
CALB2CALB2 isoform 1. (271 aa)
ENSPTRP00000075494annotation not available (194 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GPR3G protein-coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (330 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CK820_G0057017CLN3 isoform 55. (42 aa)
ENSPTRP00000082446annotation not available (194 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
CALCBCalcitonin related polypeptide beta. (138 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
ENSPTRP00000088766annotation not available (199 aa)
ENSPTRP00000090501annotation not available (192 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
RYR1RYR1 isoform 3. (5037 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
HRCHRC isoform 2. (693 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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