33 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa)
	KANSL1-2	KAT8 regulatory NSL complex subunit 1. (1105 aa)
	DNMT1-2	DNA methyltransferase 1. (1674 aa)
	AUTS2	Activator of transcription and developmental regulator AUTS2. (1259 aa)
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa)
	PHF20	PHD finger protein 20. (1012 aa)
	KANSL3	KAT8 regulatory NSL complex subunit 3. (878 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	KANSL1	KAT8 regulatory NSL complex subunit 1. (1105 aa)
	WDR61	WD repeat domain 61. (305 aa)
	RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
	MCRS1	Microspherule protein 1. (475 aa)
	HCFC1-2	HCFC1 isoform 1. (2035 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	KANSL2	KAT8 regulatory NSL complex subunit 2. (675 aa)
	ENSPTRP00000066334	annotation not available (316 aa)
	OGT	OGT isoform 6. (1057 aa)
	PHF20-2	PHD finger protein 20. (103 aa)
	KMT2E	Myeloid/lymphoid or mixed-lineage leukemia 5. (1877 aa)
	WDR5	WD repeat domain 5. (334 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
	PRDM9	PRDM9 isoform 1. (725 aa)
	GCG	GCG isoform 1. (180 aa)
	ENSPTRP00000081714	annotation not available (310 aa)
	ENSPTRP00000079733	annotation not available (1251 aa)
	NELFA	Negative elongation factor complex member A. (539 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	HCFC1	Host cell factor C1. (2080 aa)
	CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog. (1173 aa)
	PAXIP1	PAX interacting protein 1. (1067 aa)
	KAT8	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (467 aa)
	NELFE	Negative elongation factor complex member E. (389 aa)
	SNW1	SNW domain containing 1. (571 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	CTNNB1	ENSPTRP00000070120	ENSPTRP00000044466	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.508
BRCA1	DNMT1	ENSPTRP00000070120	ENSPTRP00000066034	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.525
BRCA1	DNMT1-2	ENSPTRP00000070120	ENSPTRP00000085699	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA methyltransferase 1.	0.525
BRCA1	ENSPTRP00000079733	ENSPTRP00000070120	ENSPTRP00000079733	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	annotation not available	0.726
BRCA1	KAT8	ENSPTRP00000070120	ENSPTRP00000060855	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.401
BRCA1	PAXIP1	ENSPTRP00000070120	ENSPTRP00000057306	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	PAX interacting protein 1.	0.726
BRCA1	SMAD4	ENSPTRP00000070120	ENSPTRP00000017047	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Mothers against decapentaplegic homolog.	0.488
CTNNB1	BRCA1	ENSPTRP00000044466	ENSPTRP00000070120	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.508
CTNNB1	DNMT1	ENSPTRP00000044466	ENSPTRP00000066034	Catenin (Cadherin-associated protein), beta 1, 88kDa.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.563
CTNNB1	DNMT1-2	ENSPTRP00000044466	ENSPTRP00000085699	Catenin (Cadherin-associated protein), beta 1, 88kDa.	DNA methyltransferase 1.	0.563
CTNNB1	GCG	ENSPTRP00000044466	ENSPTRP00000049083	Catenin (Cadherin-associated protein), beta 1, 88kDa.	GCG isoform 1.	0.717
CTNNB1	KAT8	ENSPTRP00000044466	ENSPTRP00000060855	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.419
CTNNB1	SMAD4	ENSPTRP00000044466	ENSPTRP00000017047	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.898
CTR9	NELFA	ENSPTRP00000041382	ENSPTRP00000027283	Ctr9, Paf1/RNA polymerase II complex component, homolog.	Negative elongation factor complex member A.	0.650
CTR9	NELFE	ENSPTRP00000041382	ENSPTRP00000063851	Ctr9, Paf1/RNA polymerase II complex component, homolog.	Negative elongation factor complex member E.	0.675
CTR9	RTF1	ENSPTRP00000041382	ENSPTRP00000011849	Ctr9, Paf1/RNA polymerase II complex component, homolog.	Rtf1, Paf1/RNA polymerase II complex component, homolog.	0.999
CTR9	WDR61	ENSPTRP00000041382	ENSPTRP00000012547	Ctr9, Paf1/RNA polymerase II complex component, homolog.	WD repeat domain 61.	0.999
DNMT1	BRCA1	ENSPTRP00000066034	ENSPTRP00000070120	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.525
DNMT1	CTNNB1	ENSPTRP00000066034	ENSPTRP00000044466	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.563
DNMT1	DNMT3B	ENSPTRP00000066034	ENSPTRP00000082164	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.998