STRINGSTRING
CLIC4 CLIC4 PEF1 PEF1 HPCA HPCA HSPA5 HSPA5 PRKAA2 PRKAA2 SLC25A24 SLC25A24 TSHB TSHB CASQ2 CASQ2 TXNIP TXNIP SYT2 SYT2 ITPKB ITPKB PPIF PPIF ANXA11 ANXA11 SMPD1 SMPD1 SYT9 SYT9 SYT13 SYT13 RASGRP2 RASGRP2 SYT12 SYT12 CPNE8 CPNE8 RASAL1 RASAL1 ALOX5AP ALOX5AP CPNE6 CPNE6 LGMN LGMN ITPKA ITPKA IQGAP1 IQGAP1 CHP2 CHP2 DPEP1 DPEP1 ALOX15 ALOX15 SYT4 SYT4 ACER1 ACER1 SLC25A23 SLC25A23 MCOLN1 MCOLN1 ITPKC ITPKC CALM3 CALM3 SYT3 SYT3 SYT5 SYT5 HPCAL1 HPCAL1 SLC25A12 SLC25A12 TTN TTN KCNB1 KCNB1 CACNG2 CACNG2 CPNE9 CPNE9 SLC6A1 SLC6A1 ADD1 ADD1 HNRNPD HNRNPD PKD2 PKD2 FGB FGB FGA FGA CRHBP CRHBP ADGRV1 ADGRV1 PCSK1 PCSK1 KCNMB1 KCNMB1 EDN1 EDN1 GPLD1 GPLD1 ITPR3 ITPR3 CPNE5 CPNE5 GUCA1A GUCA1A ADCY1 ADCY1 SLC25A13 SLC25A13 CAV1 CAV1 PTK2B PTK2B PENK PENK CPNE3 CPNE3 AQP3 AQP3 ALG2 ALG2 DMTN DMTN TRPV6 TRPV6 CASR CASR S100A16 S100A16 CPNE4 CPNE4 SYT1 SYT1 PRKAA1 PRKAA1 ENDOG ENDOG JUNB JUNB P2RX7 P2RX7 SYT10 SYT10 SUCNR1 SUCNR1 ASPH ASPH P2RX5 P2RX5 TRPC3 TRPC3 LOC453361 LOC453361 CK820_G0015936 CK820_G0015936 AMELX AMELX NLGN1 NLGN1 KCNMA1 KCNMA1 SYT11 SYT11 GIPR GIPR ENSPTRP00000063671 ENSPTRP00000063671 RYR2 RYR2 ADCY1-2 ADCY1-2 SDC1 SDC1 AHCYL1 AHCYL1 THBS1 THBS1 LOC452254 LOC452254 PPP3CA PPP3CA TRPM2 TRPM2 KCNIP2 KCNIP2 KCNMB3 KCNMB3 SCN5A SCN5A SYT15 SYT15 MEF2A MEF2A ENSPTRP00000070878 ENSPTRP00000070878 TNNT2 TNNT2 SYT7 SYT7 KCNMB4 KCNMB4 NRXN1 NRXN1 ENSPTRP00000073361 ENSPTRP00000073361 SYT8 SYT8 RASA4 RASA4 CPNE7 CPNE7 ENSPTRP00000076491 ENSPTRP00000076491 PLCG2 PLCG2 CK820_G0051619 CK820_G0051619 ECT2 ECT2 STIM1 STIM1 ADCY8 ADCY8 JUND JUND SEC31A SEC31A FOS FOS AKR1C3 AKR1C3 BRAF BRAF ACTG1 ACTG1 ENSPTRP00000081042 ENSPTRP00000081042 CARF CARF CALM1 CALM1 LOC751039 LOC751039 ENSPTRP00000082912 ENSPTRP00000082912 TRPC1 TRPC1 FGG FGG ENTPD6 ENTPD6 ENSPTRP00000083815 ENSPTRP00000083815 HOMER1 HOMER1 NEDD4 NEDD4 FOSB FOSB CCND1 CCND1 WNT5A WNT5A CPNE2 CPNE2 SYT6 SYT6 TPH2 TPH2 CAMK2D CAMK2D BRAF-2 BRAF-2 NEUROD2 NEUROD2 EEF2K EEF2K ENSPTRP00000090382 ENSPTRP00000090382 ENSPTRP00000090392 ENSPTRP00000090392 MEF2C MEF2C CK820_G0030361 CK820_G0030361 INHBB INHBB RYR3 RYR3 SYT17 SYT17 MTTP MTTP KCNMB2 KCNMB2 RYR1 RYR1 MNAT1 MNAT1 ADAM9 ADAM9 NCSTN NCSTN BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
HPCAHPCA isoform 3. (193 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SLC25A24Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (477 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
TXNIPArrestin_C domain-containing protein. (391 aa)
SYT2Synaptotagmin 2. (419 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
ANXA11Annexin. (505 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (504 aa)
SYT9Synaptotagmin IX. (491 aa)
SYT13SYT13 isoform 1. (426 aa)
RASGRP2RAS guanyl releasing protein 2. (609 aa)
SYT12Synaptotagmin 12. (420 aa)
CPNE8CPNE8 isoform 2. (564 aa)
RASAL1RAS protein activator like 1. (806 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
CPNE6CPNE6 isoform 2. (565 aa)
LGMNLGMN isoform 1. (433 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (392 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
SYT4Synaptotagmin 4. (425 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SLC25A23Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
MCOLN1MCOLN1 isoform 1. (601 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (683 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
SYT3Synaptotagmin 3. (590 aa)
SYT5Synaptotagmin 5. (386 aa)
HPCAL1Hippocalcin-like protein 1. (193 aa)
SLC25A12Solute carrier family 25 (Mitochondrial carrier, Aralar), member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
TTNTTN isoform 3. (32000 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CPNE9Copine family member 9. (553 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
ADD1ADD1 isoform 5. (768 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (866 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
ADGRV1ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
EDN1EDN1 isoform 1. (212 aa)
GPLD1GPLD1 isoform 2. (840 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
CPNE5CPNE5 isoform 2. (593 aa)
GUCA1AGUCA1A isoform 1. (207 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
SLC25A13Solute carrier family 25, member 13 (Citrin); Belongs to the mitochondrial carrier (TC 2.A.29) family. (675 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PENKPENK isoform 3. (267 aa)
CPNE3CPNE3 isoform 1. (537 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
ALG2Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog. (416 aa)
DMTNDematin actin binding protein. (405 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6. (765 aa)
CASRCalcium sensing receptor. (1078 aa)
S100A16Protein S100; Belongs to the S-100 family. (103 aa)
CPNE4CPNE4 isoform 3. (575 aa)
SYT1Synaptotagmin 1. (422 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENDOGEndonuclease. (297 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SYT10Synaptotagmin 10. (523 aa)
SUCNR1SUCNR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ASPHASPH isoform 1. (762 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (431 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
LOC453361CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
AMELXAmelogenin X-linked. (205 aa)
NLGN1NLGN1 isoform 1. (823 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
SYT11Synaptotagmin 11. (431 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
ENSPTRP00000063671annotation not available (122 aa)
RYR2RYR2 isoform 1. (4941 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
THBS1Thrombospondin 1. (1173 aa)
LOC452254LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 1-like. (863 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (279 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
SYT15SYT15 isoform 1. (479 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
ENSPTRP00000070878annotation not available (324 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
SYT7Synaptotagmin 7. (686 aa)
KCNMB4Potassium large conductance calcium-activated channel, subfamily M, beta member 4. (210 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
ENSPTRP00000073361annotation not available (388 aa)
SYT8Synaptotagmin 8. (401 aa)
RASA4Ras-GAP domain-containing protein. (757 aa)
CPNE7CPNE7 isoform 2. (526 aa)
ENSPTRP00000076491annotation not available (91 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CK820_G0051619CPNE7 isoform 9. (170 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
STIM1Stromal interaction molecule 1. (791 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
JUNDJUND isoform 1. (346 aa)
SEC31ASEC31 homolog A, COPII coat complex component. (1252 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
ACTG1ACTG1 isoform 13. (375 aa)
ENSPTRP00000081042annotation not available (262 aa)
CARFAmyotrophic lateral sclerosis 2 (Juvenile) chromosome region, candidate 8. (725 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
LOC751039Uncharacterized protein. (613 aa)
ENSPTRP00000082912annotation not available (153 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
FGGFibrinogen gamma chain. (453 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6 (Putative); Belongs to the GDA1/CD39 NTPase family. (484 aa)
ENSPTRP00000083815annotation not available (125 aa)
HOMER1HOMER1 isoform 1. (344 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CPNE2CPNE2 isoform 1. (548 aa)
SYT6Synaptotagmin 6. (548 aa)
TPH2Tryptophan hydroxylase 2. (490 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
BRAF-2BRAF isoform 2. (766 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSPTRP00000090382annotation not available (493 aa)
ENSPTRP00000090392annotation not available (93 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
INHBBInhibin subunit beta B. (407 aa)
RYR3Ryanodine receptor 3. (4873 aa)
SYT17Synaptotagmin 17. (481 aa)
MTTPMicrosomal triglyceride transfer protein. (921 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (263 aa)
RYR1RYR1 isoform 3. (5037 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
NCSTNNCSTN isoform 1. (721 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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