STRINGSTRING
ROCK1 ROCK1 CK820_G0012168 CK820_G0012168 EPB41L5 EPB41L5 LIMCH1 LIMCH1 MACF1 MACF1 WNT4 WNT4 ROCK2 ROCK2 TSC1 TSC1 CAMSAP3 CAMSAP3 FMN1 FMN1 CLASP2 CLASP2 THBS1 THBS1 SLC9A1 SLC9A1 RAC1 RAC1 DUSP22 DUSP22 TEK TEK ENSPTRP00000070878 ENSPTRP00000070878 BCAS3 BCAS3 CLASP1 CLASP1 TLN1 TLN1 ABL1 ABL1 FAM107A FAM107A GPM6B GPM6B SRC SRC MAP4K4 MAP4K4 ACTG1 ACTG1 APOD APOD FERMT2 FERMT2 ITGB1BP1 ITGB1BP1 SDC4 SDC4 PTK2 PTK2 RAC1-2 RAC1-2 DUSP3 DUSP3 POLDIP2 POLDIP2 SMAD3 SMAD3 PTEN PTEN LOC459477 LOC459477 VEGFA VEGFA ENSPTRP00000093022 ENSPTRP00000093022 PTPRA PTPRA PHLDB2 PHLDB2 SFRP1 SFRP1 RCC2 RCC2 WDPCP WDPCP DMTN DMTN LDB1 LDB1 ARHGAP6 ARHGAP6 DLC1 DLC1 EFNA5 EFNA5 KDR KDR HRG HRG EPHA3 EPHA3 RHOA RHOA PPM1F PPM1F LOC737606 LOC737606 DAPK3 DAPK3 PEAK1 PEAK1 MMP14 MMP14 CORO1C CORO1C ACVRL1 ACVRL1 THY1 THY1 PTPRJ PTPRJ SLK SLK VCL VCL NRP1 NRP1 MYOC MYOC S100A10 S100A10 COL16A1 COL16A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
LIMCH1LIM and calponin homology domains 1. (1626 aa)
MACF1Microtubule actin crosslinking factor 1. (7594 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TSC1TSC complex subunit 1. (1164 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1275 aa)
FMN1FMN1 isoform 1. (1425 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
THBS1Thrombospondin 1. (1173 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ENSPTRP00000070878annotation not available (324 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
CLASP1Cytoplasmic linker associated protein 1. (1549 aa)
TLN1TLN1 isoform 1. (2558 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
FAM107AActin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
GPM6BGlycoprotein M6B. (305 aa)
SRCTyrosine-protein kinase. (542 aa)
MAP4K4MAP4K4 isoform 6. (1347 aa)
ACTG1ACTG1 isoform 13. (375 aa)
APODApolipoprotein D. (215 aa)
FERMT2Fermitin family member 2. (706 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC459477T0188211 isoform 1. (343 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ENSPTRP00000093022annotation not available (563 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
WDPCPWDPCP isoform 2. (746 aa)
DMTNDematin actin binding protein. (405 aa)
LDB1LIM domain binding 1. (411 aa)
ARHGAP6Rho GTPase activating protein 6. (974 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HRGHistidine rich glycoprotein. (525 aa)
EPHA3EPH receptor A3. (983 aa)
RHOARas homolog family member A. (193 aa)
PPM1FPPM1F isoform 4. (454 aa)
LOC737606T0172536 isoform 1. (398 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
PEAK1NKF3 kinase family member. (1746 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
THY1Thy-1 cell surface antigen. (161 aa)
PTPRJPTPRJ isoform 4. (1312 aa)
SLKSTE20 like kinase. (1236 aa)
VCLVCL isoform 2. (1134 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MYOCMYOC isoform 1. (504 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
COL16A1Collagen type XVI alpha 1 chain. (1604 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.