STRINGSTRING
ACVR2B ACVR2B HIP1R HIP1R GATA4 GATA4 SHH SHH TGFBR2 TGFBR2 CCKBR CCKBR ENSPTRP00000074929 ENSPTRP00000074929 GATA5 GATA5 NKX2-3 NKX2-3 ADA ADA ENSPTRP00000073414 ENSPTRP00000073414 EPHB3 EPHB3 WLS WLS IFT172 IFT172 ENSPTRP00000071015 ENSPTRP00000071015 LOC100609621 LOC100609621 LOC461877 LOC461877 MIXL1 MIXL1 CDX2 CDX2 TNF TNF ENSPTRP00000069878 ENSPTRP00000069878 ENSPTRP00000069764 ENSPTRP00000069764 EGFR EGFR NKX3-2 NKX3-2 SMO-2 SMO-2 ZIC3 ZIC3 IL6ST IL6ST CK820_G0056924 CK820_G0056924 SALL1 SALL1 HES1 HES1 HOXA13 HOXA13 INSR INSR SMAD2 SMAD2 PTK6 PTK6 ENSPTRP00000062039 ENSPTRP00000062039 EPB41L5 EPB41L5 KLF5 KLF5 CYP1A1 CYP1A1 SFRP1 SFRP1 CCDC39 CCDC39 FOXF2 FOXF2 SCT SCT NIPBL NIPBL HOXA13-2 HOXA13-2 BARX1 BARX1 CRKL CRKL FOXE1 FOXE1 DNAAF1 DNAAF1 CTNNB1 CTNNB1 WDPCP WDPCP PYY PYY SOX10 SOX10 GLI2 GLI2 OTC OTC NOTCH1 NOTCH1 ASS1 ASS1 PCSK5 PCSK5 EXT1 EXT1 SOX17 SOX17 NKX2-6 NKX2-6 SLC4A2 SLC4A2 RARRES2 RARRES2 SMO SMO GLI3 GLI3 HOXA5 HOXA5 AGR2 AGR2 C1GALT1 C1GALT1 AHI1 AHI1 TCF21 TCF21 C6H6orf58 C6H6orf58 PRDM1 PRDM1 SPDEF SPDEF VPS52 VPS52 SFRP2 SFRP2 BBS7 BBS7 CXCL8 CXCL8 KIT KIT WDR19 WDR19 TP63 TP63 CLDN18 CLDN18 OXTR OXTR NKX2-2 NKX2-2 IHH IHH FZD5 FZD5 COL3A1 COL3A1 HOXD13 HOXD13 SIX2 SIX2 PKDCC PKDCC ID2 ID2 MEGF8 MEGF8 TGFB1 TGFB1 GATA6 GATA6 TYMS TYMS CCDC40 CCDC40 SOX9 SOX9 TBX2 TBX2 GIP GIP CCDC103 CCDC103 MYOCD MYOCD FOXL1 FOXL1 FOXF1 FOXF1 RBPMS2 RBPMS2 ALDH1A2 ALDH1A2 TGFB3 TGFB3 HIF1A HIF1A DACT1 DACT1 BMP4 BMP4 SAV1 SAV1 SRP54 SRP54 CHD8 CHD8 EDNRB EDNRB RB1 RB1 PDX1 PDX1 FGF9 FGF9 CELA1 CELA1 TIGAR TIGAR YAP1 YAP1 WNT11 WNT11 FGFR2 FGFR2 NODAL NODAL RET RET HLX HLX TGFB2 TGFB2 HMGCS2 HMGCS2 ENSPTRP00000084126 ENSPTRP00000084126 YIPF6 YIPF6 PERCC1 PERCC1 CK820_G0054628 CK820_G0054628 FGF10 FGF10 ALX4 ALX4 PTF1A PTF1A RARB RARB COBL COBL CLMP CLMP ENSPTRP00000081138 ENSPTRP00000081138 BMP4-2 BMP4-2 LGR4 LGR4 OVOL2 OVOL2 SHOX2 SHOX2 CBFA2T2-2 CBFA2T2-2 SOX11 SOX11 PDGFC PDGFC SMAD3 SMAD3 BCL2 BCL2 ENSPTRP00000089450 ENSPTRP00000089450 DCHS1 DCHS1 ENSPTRP00000087913 ENSPTRP00000087913 KCNQ1 KCNQ1 CPS1 CPS1 RARRES2-2 RARRES2-2 WNT5A WNT5A ENSPTRP00000085831 ENSPTRP00000085831 CBFA2T2 CBFA2T2 ENSPTRP00000080279 ENSPTRP00000080279 STRA6 STRA6 IGF2 IGF2 GLI1 GLI1 ASCL1 ASCL1 SRC SRC
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
GATA4GATA binding protein 4. (443 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (514 aa)
ENSPTRP00000074929annotation not available (367 aa)
GATA5GATA binding protein 5. (397 aa)
NKX2-3NKX2-3 isoform 1. (366 aa)
ADAAdenosine deaminase. (412 aa)
ENSPTRP00000073414annotation not available (393 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
WLSWnt ligand secretion mediator. (543 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
ENSPTRP00000071015annotation not available (408 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
MIXL1Mix paired-like homeobox. (232 aa)
CDX2Caudal type homeobox 2. (313 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ENSPTRP00000069878annotation not available (125 aa)
ENSPTRP00000069764annotation not available (1213 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ZIC3Zic family member 3. (466 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
SALL1SALL1 isoform 2. (1326 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HOXA13Homeobox A13. (388 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PTK6Tyrosine-protein kinase. (451 aa)
ENSPTRP00000062039annotation not available (397 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
FOXF2FOXF2 isoform 1. (444 aa)
SCTSCT isoform 1. (125 aa)
NIPBLNipped-B protein. (2804 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
BARX1BARX homeobox 1. (254 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
FOXE1FOXE1 isoform 1. (371 aa)
DNAAF1Dynein assembly factor 1, axonemal. (725 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WDPCPWDPCP isoform 2. (746 aa)
PYYPYY isoform 1. (95 aa)
SOX10SRY-box transcription factor 10. (466 aa)
GLI2GLI family zinc finger 2. (1587 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SOX17SOX17 isoform 1. (416 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
SLC4A2Anion exchange protein. (1239 aa)
RARRES2Retinoic acid receptor responder (Tazarotene induced) 2. (163 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA5HOXA5 isoform 1. (270 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
AHI1Abelson helper integration site 1. (1196 aa)
TCF21Transcription factor 21. (179 aa)
C6H6orf58Chromosome 6 C6orf58 homolog. (330 aa)
PRDM1PR/SET domain 1. (825 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
VPS52Vacuolar protein sorting 52 homolog. (723 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
WDR19WD repeat domain 19. (1342 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
HOXD13HOXD13 isoform 1. (344 aa)
SIX2SIX homeobox 2. (291 aa)
PKDCCPKDCC isoform 1. (461 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GATA6GATA binding protein 6. (594 aa)
TYMSThymidylate synthetase. (313 aa)
CCDC40CCDC40 isoform 3. (1142 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TBX2T-box transcription factor 2. (712 aa)
GIPGastric inhibitory polypeptide. (153 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
MYOCDMYOCD isoform 2. (986 aa)
FOXL1FOXL1 isoform 2. (345 aa)
FOXF1FOXF1 isoform 1. (433 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CELA1CELA1 isoform 1; Belongs to the peptidase S1 family. (258 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
YAP1Yes-associated protein 1. (508 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NODALNODAL isoform 2. (347 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
HLXH2.0-like homeobox. (493 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
ENSPTRP00000084126annotation not available (117 aa)
YIPF6Protein YIPF. (236 aa)
PERCC1T0176695 isoform 1. (263 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ALX4ALX homeobox 4. (411 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
RARBRetinoic acid receptor, beta. (448 aa)
COBLCordon-bleu WH2 repeat protein. (1333 aa)
CLMPCXADR-like membrane protein. (375 aa)
ENSPTRP00000081138annotation not available (325 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LGR4LGR4 isoform 2. (951 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
SHOX2SHOX2 isoform 2. (343 aa)
CBFA2T2-2CBFA2/RUNX1 partner transcriptional co-repressor 2. (614 aa)
SOX11Transcription factor SOX. (441 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000089450annotation not available (303 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
ENSPTRP00000087913annotation not available (354 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
RARRES2-2Retinoic acid receptor responder 2. (163 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000085831annotation not available (79 aa)
CBFA2T2Core-binding factor, runt domain, alpha subunit 2 translocated to, 2. (604 aa)
ENSPTRP00000080279annotation not available (270 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
IGF2Insulin like growth factor 2. (236 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
SRCTyrosine-protein kinase. (542 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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