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PFDN5 PFDN5 THRB THRB NECTIN1 NECTIN1 PDGFRB PDGFRB SLC17A8 SLC17A8 TFAP2B TFAP2B NTRK2 NTRK2 ACVR2B ACVR2B SMARCD3-2 SMARCD3-2 MERTK MERTK RHO RHO PROM1 PROM1 BMPR1B BMPR1B POU4F2 POU4F2 LPCAT1 LPCAT1 HCN1 HCN1 PDE6A PDE6A PDE6C PDE6C GRM6 GRM6 PRPH2 PRPH2 AHI1 AHI1 DLL1 DLL1 SDK1 SDK1 TSPAN12 TSPAN12 PAX4 PAX4 HIPK2 HIPK2 CASP2 CASP2 SMARCD3 SMARCD3 RP1 RP1 CHD7 CHD7 CALB1 CALB1 LHX2 LHX2 NOTCH1 NOTCH1 RS1 RS1 NDP NDP SLC4A5 SLC4A5 CRB2 CRB2 IMPDH2 IMPDH2 MFSD2A MFSD2A ATP2B1 ATP2B1 ARHGEF15 ARHGEF15 CRB1 CRB1 ACHE ACHE ATP8A2 ATP8A2 MAN2A1 MAN2A1 USH1C USH1C TENT2 TENT2 BMPR2 BMPR2 TOPORS TOPORS SLC1A1 SLC1A1 USP45 USP45 PROX1 PROX1 ZHX2 ZHX2 LHX1 LHX1 BBS4 BBS4 OBSL1 OBSL1 MEGF11 MEGF11 RORB RORB FJX1 FJX1 NEUROD4 NEUROD4 ENSPTRP00000062542 ENSPTRP00000062542 PFDN5-2 PFDN5-2 ENSPTRP00000063978 ENSPTRP00000063978 HES1 HES1 RPL24 RPL24 ENSPTRP00000065085 ENSPTRP00000065085 PAX6 PAX6 SKI SKI CLIC4 CLIC4 HPCA HPCA RPE65 RPE65 BARHL2 BARHL2 GNAT2 GNAT2 HIPK1 HIPK1 RD3 RD3 TGFB2 TGFB2 NRP1 NRP1 RET RET ATOH7 ATOH7 TUB TUB IGSF22 IGSF22 CNTF CNTF ROM1 ROM1 TCIRG1 TCIRG1 FZD4 FZD4 MFRP MFRP THY1 THY1 ACVRL1 ACVRL1 GDF11 GDF11 FOXN4 FOXN4 NRL NRL HIF1A HIF1A RHOJ RHOJ PSEN1 PSEN1 TTLL5 TTLL5 SOX8 SOX8 RPGRIP1L RPGRIP1L SERPINF1 SERPINF1 TTC8 TTC8 CLCN2 CLCN2 ENSPTRP00000066927 ENSPTRP00000066927 GNB1 GNB1 DTNBP1 DTNBP1 DCX DCX VSTM4 VSTM4 FAT3 FAT3 CDON CDON LRP5 LRP5 AGTPBP1 AGTPBP1 ATP2B4 ATP2B4 PDE6B PDE6B CASP2-2 CASP2-2 CABP4 CABP4 ACTL6A ACTL6A NR2E1 NR2E1 SMARCA4 SMARCA4 RPGRIP1 RPGRIP1 NPHP1 NPHP1 CLN8 CLN8 NECTIN3 NECTIN3 SCAPER SCAPER GPM6A GPM6A NR2E3 NR2E3 ENSPTRP00000076491 ENSPTRP00000076491 MED1 MED1 SOX9 SOX9 SDK2 SDK2 JMJD6 JMJD6 PTPRM PTPRM BSG BSG SLC17A7 SLC17A7 RDH13 RDH13 HPCAL1 HPCAL1 ZNF513 ZNF513 CYP1B1 CYP1B1 VAX2 VAX2 IHH IHH XRN2 XRN2 TGIF2 TGIF2 NAGLU NAGLU BHLHE23 BHLHE23 DSCAM DSCAM LRP5L LRP5L LAMB2 LAMB2 GNAT1 GNAT1 IMPG2 IMPG2 TBC1D32 TBC1D32 NPHP4 NPHP4 BAX BAX TULP1 TULP1 RP1L1 RP1L1 STAT3 STAT3 COL4A1 COL4A1 PAX2 PAX2 NR2E1-2 NR2E1-2 LAMC3 LAMC3 ENSPTRP00000088795 ENSPTRP00000088795 IGFN1 IGFN1 ENSPTRP00000088146 ENSPTRP00000088146 MAX MAX TFAP2A TFAP2A ATP2B2 ATP2B2 ROM1-2 ROM1-2 LAMA1 LAMA1 VSX1 VSX1 ENSPTRP00000083623 ENSPTRP00000083623 DCLK1 DCLK1 PTF1A PTF1A ENSPTRP00000082912 ENSPTRP00000082912 MDM1 MDM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFDN5Prefoldin subunit 5. (154 aa)
THRBThyroid hormone receptor beta. (476 aa)
NECTIN1NECTIN1 isoform 1. (517 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SLC17A8SLC17A8 isoform 1. (589 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
MERTKMERTK isoform 1. (963 aa)
RHORhodopsin. (348 aa)
PROM1PROM1 isoform 12. (865 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
POU4F2POU domain protein. (406 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (534 aa)
HCN1HCN1 isoform 1. (886 aa)
PDE6APhosphodiesterase. (876 aa)
PDE6CPhosphodiesterase. (858 aa)
GRM6GRM6 isoform 2. (879 aa)
PRPH2PRPH2 isoform 1. (346 aa)
AHI1Abelson helper integration site 1. (1196 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SDK1SDK1 isoform 1. (2007 aa)
TSPAN12Tetraspanin. (305 aa)
PAX4PAX4 isoform 1. (351 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
CASP2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
RP1RP1 axonemal microtubule associated. (2156 aa)
CHD7CHD7 isoform 1. (2997 aa)
CALB1CALB1 isoform 3. (261 aa)
LHX2LHX2 isoform 1. (406 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
RS1Retinoschisin 1. (224 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
SLC4A5Anion exchange protein. (1136 aa)
CRB2CRB2 isoform 1. (1285 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
ARHGEF15ARHGEF15 isoform 3. (841 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
USH1CUSH1C isoform 4. (899 aa)
TENT2PAPD4 isoform 1. (484 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
TOPORSTopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase. (1045 aa)
SLC1A1Amino acid transporter. (524 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (814 aa)
PROX1Prospero homeobox 1. (737 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
OBSL1OBSL1 isoform 6. (1895 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
RORBRAR related orphan receptor B. (482 aa)
FJX1Four-jointed box kinase 1. (437 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
ENSPTRP00000062542annotation not available (147 aa)
PFDN5-2Prefoldin subunit 5. (127 aa)
ENSPTRP00000063978annotation not available (224 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RPL24RPL24 isoform 1. (157 aa)
ENSPTRP00000065085annotation not available (133 aa)
PAX6PAX6 isoform 13. (436 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
HPCAHPCA isoform 3. (193 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
BARHL2BarH like homeobox 2. (387 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
HIPK1HIPK1 isoform 10. (1210 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (195 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
IGSF22IGSF22 isoform 3. (1326 aa)
CNTFCiliary neurotrophic factor. (200 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
MFRPMembrane frizzled-related protein. (579 aa)
THY1Thy-1 cell surface antigen. (161 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF11GDF11 isoform 1. (407 aa)
FOXN4FOXN4 isoform 2. (517 aa)
NRLNeural retina leucine zipper. (237 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
RHOJRas homolog gene family, member J. (214 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
TTLL5TTLL5 isoform 7. (1299 aa)
SOX8SOX8 isoform 1. (446 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
SERPINF1SERPINF1 isoform 1; Belongs to the serpin family. (418 aa)
TTC8Tetratricopeptide repeat domain 8. (531 aa)
CLCN2Chloride channel protein. (898 aa)
ENSPTRP00000066927annotation not available (133 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
DTNBP1Dystrobrevin binding protein 1. (351 aa)
DCXDCX isoform 5. (420 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
FAT3FAT3 isoform 2. (4612 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
PDE6BPDE6B isoform 6. (747 aa)
CASP2-2Caspase 2. (452 aa)
CABP4Calcium binding protein 4. (275 aa)
ACTL6AACTL6A isoform 2; Belongs to the actin family. (430 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
RPGRIP1RPGR interacting protein 1. (1287 aa)
NPHP1NPHP1 isoform 1. (729 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
NECTIN3Poliovirus receptor-related 3. (549 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1403 aa)
GPM6AGlycoprotein M6A. (278 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (410 aa)
ENSPTRP00000076491annotation not available (91 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SDK2SDK2 isoform 1. (2172 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
PTPRMPTPRM isoform 4. (1465 aa)
BSGBSG isoform 8. (383 aa)
SLC17A7SLC17A7 isoform 1. (570 aa)
RDH13Retinol dehydrogenase 13 (All-trans/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
HPCAL1Hippocalcin-like protein 1. (193 aa)
ZNF513Zinc finger protein 513. (541 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
VAX2Ventral anterior homeobox 2. (290 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
BHLHE23Basic helix-loop-helix family member e23. (241 aa)
DSCAMDS cell adhesion molecule. (2012 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
GNAT1G protein subunit alpha transducin 1. (350 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1243 aa)
TBC1D32TBC1D32 isoform 4. (1298 aa)
NPHP4NPHP4 isoform 5. (1426 aa)
BAXBAX isoform 7. (123 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (542 aa)
RP1L1RP1L1 isoform 1. (2257 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PAX2PAX2 isoform 1. (417 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
LAMC3Laminin subunit gamma 3. (1580 aa)
ENSPTRP00000088795annotation not available (62 aa)
IGFN1IGFN1 isoform 3. (3703 aa)
ENSPTRP00000088146annotation not available (157 aa)
MAXMYC associated factor X. (162 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ROM1-2Retinal outer segment membrane protein 1. (351 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
VSX1Visual system homeobox 1. (365 aa)
ENSPTRP00000083623annotation not available (133 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
ENSPTRP00000082912annotation not available (153 aa)
MDM1MDM1 isoform 2. (725 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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