STRINGSTRING
MAPK11 MAPK11 ENSPTRP00000093588 ENSPTRP00000093588 ENSPTRP00000093022 ENSPTRP00000093022 RUNX1 RUNX1 NRG1 NRG1 PTEN PTEN VGLL4 VGLL4 MEF2C MEF2C FGF20 FGF20 CITED2 CITED2 RBPJ RBPJ BMP10 BMP10 GLI1 GLI1 TGFBR2 TGFBR2 ZFPM2 ZFPM2 TGFBR1 TGFBR1 ENSPTRP00000072925 ENSPTRP00000072925 TBX5 TBX5 JARID2 JARID2 ENSPTRP00000066578 ENSPTRP00000066578 TGFBR3 TGFBR3 ENSPTRP00000065655 ENSPTRP00000065655 TP73 TP73 ENSPTRP00000064416 ENSPTRP00000064416 ERBB4 ERBB4 KCNK2 KCNK2 CDK1 CDK1 NOTCH1 NOTCH1 WNT2 WNT2 TBX20 TBX20 HEY2 HEY2 PIM1 PIM1 MAPK14 MAPK14 NKX2-5 NKX2-5 CXADR CXADR GATA6 GATA6 TBX2 TBX2 NOG NOG SAV1 SAV1 FGF9 FGF9 YAP1 YAP1 FGFR2 FGFR2 BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11Mitogen-activated protein kinase. (364 aa)
ENSPTRP00000093588annotation not available (361 aa)
ENSPTRP00000093022annotation not available (563 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
NRG1NRG1 isoform 3. (713 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
VGLL4Vestigial like family member 4. (296 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GLI1GLI family zinc finger 1. (1106 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENSPTRP00000072925annotation not available (372 aa)
TBX5T-box transcription factor 5. (518 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
ENSPTRP00000066578annotation not available (310 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
ENSPTRP00000065655annotation not available (349 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
ENSPTRP00000064416annotation not available (502 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
GATA6GATA binding protein 6. (594 aa)
TBX2T-box transcription factor 2. (712 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
YAP1Yes-associated protein 1. (508 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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