STRINGSTRING
WNT2 WNT2 TBX20 TBX20 TBX2 TBX2 HEY2 HEY2 PIM1 PIM1 NRG1 NRG1 MEF2C MEF2C RBPJ RBPJ BMP10 BMP10 BMPR1A BMPR1A FGFR2 FGFR2 YAP1 YAP1 FGF9 FGF9 MAPK14 MAPK14 GATA6 GATA6 ZFPM2 ZFPM2 TBX5 TBX5 TGFBR3 TGFBR3 ENSPTRP00000064416 ENSPTRP00000064416 ERBB4 ERBB4 CDK1 CDK1 NOTCH1 NOTCH1 GLI1 GLI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
TBX20T-box transcription factor 20. (447 aa)
TBX2T-box transcription factor 2. (712 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
NRG1NRG1 isoform 3. (713 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
YAP1Yes-associated protein 1. (508 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
GATA6GATA binding protein 6. (594 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
TBX5T-box transcription factor 5. (518 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
ENSPTRP00000064416annotation not available (502 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
GLI1GLI family zinc finger 1. (1106 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.