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MTOR MTOR CASQ2 CASQ2 ATP1B1 ATP1B1 TNNI1 TNNI1 CSRP3 CSRP3 MYBPC3 MYBPC3 GRK2 GRK2 SCN3B SCN3B CACNA1C CACNA1C KCNA5 KCNA5 KCNJ8 KCNJ8 PKP2 PKP2 SGCG SGCG RANGRF RANGRF TCAP TCAP KCNJ2 KCNJ2 GATA6 GATA6 PPP1R13L PPP1R13L KCNJ3 KCNJ3 SCN1A SCN1A TTN TTN KCNE4 KCNE4 MYLK2 MYLK2 SNTA1 SNTA1 SOD1 SOD1 KCNE1 KCNE1 CAV3 CAV3 MYL3 MYL3 TNNC1 TNNC1 KCNN2 KCNN2 NKX2-5 NKX2-5 ATG5 ATG5 MYL7 MYL7 MYL10 MYL10 SGCZ SGCZ EXT1 EXT1 GSN GSN TAZ TAZ ACE ACE TPM1 TPM1 GAA GAA CACNB2 CACNB2 MYL4 MYL4 ANK2 ANK2 KCNH2 KCNH2 VEGFB VEGFB TNNI3 TNNI3 SLC1A1 SLC1A1 GPX1 GPX1 KCNE2 KCNE2 TRDN TRDN SGCD SGCD KCNE5 KCNE5 KCND3 KCND3 KCNE3 KCNE3 ENSPTRP00000061486 ENSPTRP00000061486 MAP2K6 MAP2K6 NEDD4L NEDD4L RPS6KA2 RPS6KA2 SLC8A1 SLC8A1 RYR2 RYR2 CACNA1G CACNA1G LOC736481 LOC736481 TNNI2 TNNI2 SLC9A1 SLC9A1 ENSPTRP00000068927 ENSPTRP00000068927 SCN5A SCN5A DMD DMD DNM1L DNM1L LOC736283 LOC736283 GPD1L GPD1L TNNT2 TNNT2 CACNA2D1 CACNA2D1 SCN2B SCN2B CACNA1D CACNA1D MYL10-2 MYL10-2 CDC42 CDC42 NUP155 NUP155 ACCS ACCS MYL2 MYL2 SMAD5 SMAD5 ENSPTRP00000081633 ENSPTRP00000081633 MYH7 MYH7 ATP1A2 ATP1A2 CK820_G0053450-2 CK820_G0053450-2 ABCC9 ABCC9 DMD-2 DMD-2 PIK3CA PIK3CA ENSPTRP00000086934 ENSPTRP00000086934 KCNQ1 KCNQ1 CAMK2D CAMK2D MYH6 MYH6 SCN1B SCN1B FGF12 FGF12 ATP1A1 ATP1A1 SCN4B SCN4B ENSPTRP00000091918 ENSPTRP00000091918 ENSPTRP00000092784 ENSPTRP00000092784 KCNJ5 KCNJ5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
KCNJ8Potassium inwardly-rectifying channel, subfamily J, member 8. (424 aa)
PKP2PKP2 isoform 1. (837 aa)
SGCGSarcoglycan, gamma (35kDa dystrophin-associated glycoprotein). (291 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
TCAPTCAP isoform 1. (167 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
GATA6GATA binding protein 6. (594 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
TTNTTN isoform 3. (32000 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
MYLK2MYLK2 isoform 1. (596 aa)
SNTA1Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component). (505 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
KCNE1KCNE1B isoform 1. (132 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
KCNN2Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2. (843 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MYL7Myosin light chain 7. (175 aa)
MYL10ADCY7 isoform 13. (226 aa)
SGCZSarcoglycan zeta. (312 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GSNGSN isoform 3. (782 aa)
TAZTafazzin; Some isoforms may be involved in cardiolipin metabolism; Belongs to the taffazin family. (286 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
GAAGlucosidase, alpha acid; Belongs to the glycosyl hydrolase 31 family. (952 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
MYL4Myosin, light chain 4, alkali atrial, embryonic. (193 aa)
ANK2ANK2 isoform 1. (3957 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TNNI3TNNI3 isoform 2. (169 aa)
SLC1A1Amino acid transporter. (524 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
KCNE2KCNE2 isoform 1. (123 aa)
TRDNTRDN isoform 1. (730 aa)
SGCDSarcoglycan, delta (35kDa dystrophin-associated glycoprotein). (290 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCND3Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (655 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RYR2RYR2 isoform 1. (4941 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
TNNI2Troponin I type 2 (Skeletal, fast). (179 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ENSPTRP00000068927annotation not available (480 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
DMDDMD isoform 3. (3685 aa)
DNM1LDNM1L isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
LOC736283Glutathione peroxidase 1 pseudogene. (188 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MYL10-2MYL10 isoform 1. (226 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
NUP155Nucleoporin 155kDa. (1391 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ENSPTRP00000081633annotation not available (139 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CK820_G0053450-2MAP2K3 isoform 2. (298 aa)
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 9. (1549 aa)
DMD-2Dystrophin. (643 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
ENSPTRP00000086934annotation not available (467 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
ENSPTRP00000091918annotation not available (454 aa)
ENSPTRP00000092784annotation not available (75 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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