STRINGSTRING
ZNF358 ZNF358 KAT2B KAT2B ZNRF3 ZNRF3 BMP7 BMP7 IFT52 IFT52 GDF5 GDF5 RSPO4 RSPO4 IHH IHH COL3A1 COL3A1 HOXD10 HOXD10 HOXD13 HOXD13 EVX2 EVX2 LNPK LNPK MAP3K20 MAP3K20 AFF3 AFF3 PKDCC PKDCC OSR1 OSR1 MEGF8 MEGF8 PIAS4 PIAS4 RAX RAX SMAD4 SMAD4 RNF165 RNF165 SOX9 SOX9 TBX4 TBX4 TBX2 TBX2 MKS1 MKS1 NOG NOG WNT3 WNT3 KAT2A KAT2A MED1 MED1 FOXN1 FOXN1 B9D1 B9D1 TMEM107 TMEM107 MED31 MED31 RPGRIP1L RPGRIP1L KREMEN2 KREMEN2 IFT140 IFT140 ALDH1A2 ALDH1A2 PSEN1 PSEN1 SMOC1 SMOC1 BMP4 BMP4 FREM2 FREM2 FGF9 FGF9 PRKAB1 PRKAB1 HOXC10 HOXC10 HOXC11 HOXC11 HOXC13 HOXC13 KRT84 KRT84 CACNA1C CACNA1C ZBTB16 ZBTB16 FGF4 FGF4 FGFR2 FGFR2 BMPR1A BMPR1A DKK1 DKK1 TGFB2 TGFB2 FLVCR1 FLVCR1 PLXNA2 PLXNA2 PRRX1 PRRX1 CRABP2 CRABP2 ALX3 ALX3 KDF1 KDF1 CPLANE2 CPLANE2 SKI SKI EN1 EN1 HDAC2 HDAC2 KREMEN1 KREMEN1 BAK1 BAK1 SOX4 SOX4 HAND2 HAND2 RARA RARA ASPH ASPH TMEM231 TMEM231 MSX1 MSX1 SP8 SP8 COMP COMP DLX6 DLX6 TAF10 TAF10 HOXD12 HOXD12 PBX1 PBX1 LOC104003639 LOC104003639 HOXA13 HOXA13 C2CD3 C2CD3 FMN1 FMN1 RSPO2 RSPO2 ENSPTRP00000064416 ENSPTRP00000064416 SALL1 SALL1 WNT7A WNT7A RUNX2 RUNX2 ZIC3 ZIC3 HOXA10 HOXA10 TMEM107-2 TMEM107-2 ENSPTRP00000066776 ENSPTRP00000066776 HOXA10-2 HOXA10-2 LOC748850 LOC748850 TULP3 TULP3 SLC7A11 SLC7A11 LRP5 LRP5 TBX5 TBX5 ENSPTRP00000069764 ENSPTRP00000069764 IQCE IQCE IFT172 IFT172 IMPAD1 IMPAD1 MYH3 MYH3 SCX SCX LOC100614251 LOC100614251 CREBBP CREBBP FGF8 FGF8 SHH SHH NOTCH2 NOTCH2 HDAC1 HDAC1 SALL4 SALL4 BCL2L11 BCL2L11 ENSPTRP00000077262 ENSPTRP00000077262 FBXW4 FBXW4 TFAP2B TFAP2B DYNC2H1 DYNC2H1 WNT3-2 WNT3-2 ENSPTRP00000078515 ENSPTRP00000078515 HOXD9 HOXD9 SP9 SP9 LEF1 LEF1 CYP26B1 CYP26B1 BMP4-2 BMP4-2 FERMT2 FERMT2 LRP4 LRP4 ACD ACD ITGB4 ITGB4 RARB RARB RARG RARG ALX4 ALX4 FGF10 FGF10 MBNL1 MBNL1 HNF1A HNF1A TBX3 TBX3 WNT5A WNT5A TFAP2A TFAP2A ATRX ATRX PTCH1 PTCH1 ITGA6 ITGA6 ECE1 ECE1 SOX11 SOX11 FBN2 FBN2 SHOX2 SHOX2 IRF6 IRF6 CHST11 CHST11 BAX BAX ZNF219 ZNF219 TBC1D32 TBC1D32 OSR2 OSR2 IFT122 IFT122 IFT80 IFT80 TP63 TP63 ZNF141 ZNF141 WDR19 WDR19 PITX2 PITX2 BBS7 BBS7 INTU INTU SFRP2 SFRP2 CPLANE1 CPLANE1 PITX1 PITX1 PBX2 PBX2 GNA12 GNA12 MEOX2 MEOX2 HOXA11 HOXA11 GLI3 GLI3 SEMA3C SEMA3C DLX5 DLX5 CHD7 CHD7 RDH10 RDH10 GRHL2 GRHL2 EXT1 EXT1 RECK RECK PCSK5 PCSK5 RC3H2 RC3H2 NOTCH1 NOTCH1 LMBR1 LMBR1 COL2A1 COL2A1 SLC39A1 SLC39A1 FZD6 FZD6 WDPCP WDPCP CTNNB1 CTNNB1 FRAS1 FRAS1 HOXA13-2 HOXA13-2 TWIST1 TWIST1 PAM PAM NIPBL NIPBL BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF358Zinc finger protein 358. (559 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
ZNRF3ZNRF3 isoform 1. (920 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
GDF5GDF5 isoform 1. (501 aa)
RSPO4RSPO4 isoform 1. (234 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
HOXD13HOXD13 isoform 1. (344 aa)
EVX2Even-skipped homeobox 2. (476 aa)
LNPKLunapark, ER junction formation factor. (459 aa)
MAP3K20Sterile alpha motif and leucine zipper containing kinase AZK. (803 aa)
AFF3AFF3 isoform 5. (1233 aa)
PKDCCPKDCC isoform 1. (461 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
PIAS4Protein inhibitor of activated STAT protein 4. (510 aa)
RAXRetina and anterior neural fold homeobox. (346 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RNF165Ring finger protein 165. (346 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TBX4TBX4 isoform 1. (545 aa)
TBX2T-box transcription factor 2. (712 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
FOXN1FOXN1 isoform 2. (648 aa)
B9D1B9 domain containing 1. (204 aa)
TMEM107Transmembrane protein 107. (146 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
IFT140Intraflagellar transport 140 homolog. (1471 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SMOC1SPARC related modular calcium binding 1. (435 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FREM2FRAS1 related extracellular matrix 2. (3169 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
HOXC11HOXC11 isoform 1. (304 aa)
HOXC13HOXC13 isoform 1. (330 aa)
KRT84KRT84 isoform 1; Belongs to the intermediate filament family. (600 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DKK1Dickkopf-like protein 1. (289 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
PRRX1Paired related homeobox 1. (245 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
ALX3ALX homeobox 3. (343 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
EN1Homeobox protein engrailed-like. (396 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
SOX4Transcription factor SOX. (474 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
RARARARA isoform 4. (624 aa)
ASPHASPH isoform 1. (762 aa)
TMEM231T0150531 isoform 1. (345 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SP8Sp8 transcription factor. (507 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
DLX6DLX6 isoform 1. (295 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
HOXD12HOXD12 isoform 1. (270 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
HOXA13Homeobox A13. (388 aa)
C2CD3C2CD3 isoform 3. (2298 aa)
FMN1FMN1 isoform 1. (1425 aa)
RSPO2R-spondin 2 homolog. (243 aa)
ENSPTRP00000064416annotation not available (502 aa)
SALL1SALL1 isoform 2. (1326 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
ZIC3Zic family member 3. (466 aa)
HOXA10HOXA10 isoform 2. (410 aa)
TMEM107-2Transmembrane protein 107. (140 aa)
ENSPTRP00000066776annotation not available (570 aa)
HOXA10-2Homeobox A10. (410 aa)
LOC748850HDAC2 isoform 9. (445 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
TBX5T-box transcription factor 5. (518 aa)
ENSPTRP00000069764annotation not available (1213 aa)
IQCEIQCE isoform 2. (841 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
MYH3Myosin, heavy chain 3, skeletal muscle, embryonic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
LOC100614251F-box/WD repeat-containing protein 4 pseudogene. (342 aa)
CREBBPCREB binding protein. (2442 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SALL4SALL4 isoform 1. (1053 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSPTRP00000077262annotation not available (314 aa)
FBXW4F-box and WD repeat domain containing 4. (412 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
DYNC2H1DYNC2H1 isoform 4. (4314 aa)
WNT3-2Wnt family member 3. (290 aa)
ENSPTRP00000078515annotation not available (198 aa)
HOXD9HOXD9 isoform 1. (356 aa)
SP9Sp9 transcription factor. (481 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FERMT2Fermitin family member 2. (706 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ACDACD isoform 1. (458 aa)
ITGB4Integrin beta. (1822 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
ALX4ALX homeobox 4. (411 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
HNF1AHNF1 homeobox A. (662 aa)
TBX3T-box transcription factor 3. (743 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ATRXTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2492 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
SOX11Transcription factor SOX. (441 aa)
FBN2FBN2 isoform 1. (2912 aa)
SHOX2SHOX2 isoform 2. (343 aa)
IRF6Interferon regulatory factor 6. (467 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
BAXBAX isoform 7. (123 aa)
ZNF219Zinc finger protein 219. (722 aa)
TBC1D32TBC1D32 isoform 4. (1298 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
IFT122IFT122 isoform 10. (1286 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ZNF141Zinc finger protein 141. (474 aa)
WDR19WD repeat domain 19. (1342 aa)
PITX2Homeobox protein. (324 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
PITX1Homeobox protein. (314 aa)
PBX2Pre-B-cell leukemia homeobox 2. (430 aa)
GNA12Guanine nucleotide binding protein (G protein) alpha 12. (381 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
DLX5Distal-less homeobox 5. (289 aa)
CHD7CHD7 isoform 1. (2997 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RECKReversion-inducing-cysteine-rich protein with kazal motifs. (965 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LMBR1LMBR1 isoform 7; Belongs to the LIMR family. (531 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SLC39A1Solute carrier family 39 (Zinc transporter), member 1. (324 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
WDPCPWDPCP isoform 2. (746 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4012 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
TWIST1TWIST1 isoform 2. (163 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
NIPBLNipped-B protein. (2804 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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