16 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX10	SRY-box transcription factor 10. (466 aa)
	ABCC8	ABCC8 isoform 2. (1582 aa)
	DICER1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	NF2	Neurofibromin 2 (Merlin). (595 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (193 aa)
	CDKN2B	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
	SOX11	Transcription factor SOX. (441 aa)
	SKI	V-ski sarcoma viral oncogene homolog (Avian). (736 aa)
	RNF10	Ring finger protein 10. (816 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	NF1	Neurofibromin 1. (2839 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	CERS2	LAG1 homolog, ceramide synthase 2. (380 aa)
	TSPO	Translocator protein. (169 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	HES1	ENSPTRP00000080760	ENSPTRP00000064171	Achaete-scute family bHLH transcription factor 2.	Hes family bHLH transcription factor 1.	0.448
CDKN2B	HES1	ENSPTRP00000082876	ENSPTRP00000064171	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Hes family bHLH transcription factor 1.	0.441
CDKN2B	NF1	ENSPTRP00000082876	ENSPTRP00000015312	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Neurofibromin 1.	0.428
CDKN2B	RB1	ENSPTRP00000082876	ENSPTRP00000009974	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	RB transcriptional corepressor 1.	0.423
CDKN2B	TP53	ENSPTRP00000082876	ENSPTRP00000014836	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.833
DICER1	TP53	ENSPTRP00000046628	ENSPTRP00000014836	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.603
HES1	ASCL2	ENSPTRP00000064171	ENSPTRP00000080760	Hes family bHLH transcription factor 1.	Achaete-scute family bHLH transcription factor 2.	0.448
HES1	CDKN2B	ENSPTRP00000064171	ENSPTRP00000082876	Hes family bHLH transcription factor 1.	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	0.441
HES1	NOTCH1	ENSPTRP00000064171	ENSPTRP00000036924	Hes family bHLH transcription factor 1.	NOTCH1 isoform 1.	0.642
NF1	CDKN2B	ENSPTRP00000015312	ENSPTRP00000082876	Neurofibromin 1.	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	0.428
NF1	NF2	ENSPTRP00000015312	ENSPTRP00000072446	Neurofibromin 1.	Neurofibromin 2 (Merlin).	0.802
NF1	NOTCH1	ENSPTRP00000015312	ENSPTRP00000036924	Neurofibromin 1.	NOTCH1 isoform 1.	0.433
NF1	TP53	ENSPTRP00000015312	ENSPTRP00000014836	Neurofibromin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.724
NF2	NF1	ENSPTRP00000072446	ENSPTRP00000015312	Neurofibromin 2 (Merlin).	Neurofibromin 1.	0.802
NF2	TP53	ENSPTRP00000072446	ENSPTRP00000014836	Neurofibromin 2 (Merlin).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.583
NOTCH1	HES1	ENSPTRP00000036924	ENSPTRP00000064171	NOTCH1 isoform 1.	Hes family bHLH transcription factor 1.	0.642
NOTCH1	NF1	ENSPTRP00000036924	ENSPTRP00000015312	NOTCH1 isoform 1.	Neurofibromin 1.	0.433
NOTCH1	TP53	ENSPTRP00000036924	ENSPTRP00000014836	NOTCH1 isoform 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.614
RB1	CDKN2B	ENSPTRP00000009974	ENSPTRP00000082876	RB transcriptional corepressor 1.	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	0.423
RB1	TP53	ENSPTRP00000009974	ENSPTRP00000014836	RB transcriptional corepressor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.763