STRINGSTRING
SNTA1 SNTA1 KCNE4 KCNE4 KCNJ2 KCNJ2 YWHAE YWHAE AKAP6 AKAP6 KCNA5 KCNA5 CASQ2 CASQ2 NPPA NPPA ENSPTRP00000091918 ENSPTRP00000091918 SCN4B SCN4B ENSPTRP00000090501 ENSPTRP00000090501 SCN1B SCN1B ENSPTRP00000088766 ENSPTRP00000088766 KCNQ1 KCNQ1 KCNH6 KCNH6 CACNB3 CACNB3 ENSPTRP00000086934 ENSPTRP00000086934 GJA5 GJA5 LOC459638 LOC459638 ENSPTRP00000082446 ENSPTRP00000082446 ZMPSTE24 ZMPSTE24 CACNA1D CACNA1D ENSPTRP00000075494 ENSPTRP00000075494 CACNA2D1 CACNA2D1 SCN5A SCN5A ENSPTRP00000068927 ENSPTRP00000068927 AKAP9-2 AKAP9-2 FLNA FLNA NEDD4L NEDD4L KCNE3 KCNE3 KCNE5 KCNE5 KCNE2 KCNE2 RNF207 RNF207 AKAP9 AKAP9 KCNH2 KCNH2 ANK2 ANK2 NOS1AP NOS1AP CAV1 CAV1 AKAP7 AKAP7 WDR1 WDR1 CAV3 CAV3 KCNE1 KCNE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNTA1Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component). (505 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
NPPANatriuretic peptide A. (153 aa)
ENSPTRP00000091918annotation not available (454 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
ENSPTRP00000090501annotation not available (192 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
ENSPTRP00000088766annotation not available (199 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
ENSPTRP00000086934annotation not available (467 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000082446annotation not available (194 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSPTRP00000075494annotation not available (194 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
ENSPTRP00000068927annotation not available (480 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
FLNAFLNA isoform 8. (2711 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCNE2KCNE2 isoform 1. (123 aa)
RNF207Ring finger protein 207. (634 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
ANK2ANK2 isoform 1. (3957 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (506 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
WDR1WD repeat domain 1. (606 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
KCNE1KCNE1B isoform 1. (132 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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