STRINGSTRING
WNT2 WNT2 HEY2 HEY2 BMP2 BMP2 SMAD4 SMAD4 TGFB2 TGFB2 EFNA1 EFNA1 HEYL HEYL TMEM100 TMEM100 TBX3 TBX3 SPRY1 SPRY1 PDCD4 PDCD4 RBPJ RBPJ FGF8 FGF8 TGFBR1 TGFBR1 HEY1 HEY1 TGFBR3 TGFBR3 SNAI1 SNAI1 HAS2 HAS2 MSX1 MSX1 RTN4 RTN4 OLFM1 OLFM1 ADAM15 ADAM15 NOTCH1 NOTCH1 ENG ENG SNAI2 SNAI2 WNT16 WNT16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
TMEM100Transmembrane protein 100. (134 aa)
TBX3T-box transcription factor 3. (743 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HAS2Hyaluronan synthase 2. (554 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
RTN4Reticulon. (1192 aa)
OLFM1OLFM1 isoform 3. (485 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.