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COL27A1 COL27A1 NAB2 NAB2 MMP14 MMP14 BMP4 BMP4 TGFB3 TGFB3 TRIP11 TRIP11 SMPD3 SMPD3 TMEM107 TMEM107 PHOSPHO1 PHOSPHO1 COL1A1 COL1A1 AXIN2 AXIN2 SOX9 SOX9 ACP5 ACP5 TGFB1 TGFB1 MEGF8 MEGF8 INSIG2 INSIG2 COL3A1 COL3A1 NAB1 NAB1 IHH IHH NPPC NPPC PAX1 PAX1 CBS CBS LRP5L LRP5L LTF LTF IFT80 IFT80 BMPR1B BMPR1B NEUROG1 NEUROG1 CDX1 CDX1 BMP6 BMP6 PEX7 PEX7 TBXT TBXT HOXA11 HOXA11 SFRP4 SFRP4 GLI3 GLI3 DLX5 DLX5 INSIG1 INSIG1 STC1 STC1 EXT1 EXT1 CER1 CER1 COL2A1 COL2A1 COL13A1 COL13A1 ATG9B ATG9B TSKU TSKU IFITM5 IFITM5 BMPR2 BMPR2 SP5 SP5 FREM1 FREM1 RIPPLY2 RIPPLY2 RARA RARA MSX1 MSX1 PHOSPHO2 PHOSPHO2 COMP COMP HAS2 HAS2 LOC104003639 LOC104003639 ATF2 ATF2 FOXN3 FOXN3 ENSPTRP00000063945 ENSPTRP00000063945 FOXC1 FOXC1 RUNX2 RUNX2 TMEM107-2 TMEM107-2 LRP5 LRP5 GLG1 GLG1 ENSPTRP00000070794 ENSPTRP00000070794 IMPAD1 IMPAD1 TMEM119 TMEM119 SCX SCX TIFAB TIFAB MEF2D MEF2D RAB23 RAB23 GHR GHR ALPL ALPL TGFBR2 TGFBR2 TRPV4 TRPV4 MMP16 MMP16 DCANP1 DCANP1 ENSPTRP00000075468 ENSPTRP00000075468 MMP13 MMP13 ENSPTRP00000077262 ENSPTRP00000077262 ACCS ACCS ZMPSTE24 ZMPSTE24 CYP26B1 CYP26B1 BMP4-2 BMP4-2 ANXA6 ANXA6 CITED2 CITED2 RARB RARB RARG RARG ACTN3 ACTN3 TFAP2A TFAP2A FGFR3 FGFR3 MEF2C MEF2C FGF18 FGF18 SHOX2 SHOX2 SCUBE2 SCUBE2 ATG9A ATG9A ENSPTRP00000092702 ENSPTRP00000092702 OSR2 OSR2 TWIST1 TWIST1 SKI SKI DHRS3 DHRS3 MATN1 MATN1 THBS3 THBS3 PAPPA2 PAPPA2 FGFR2 FGFR2 LTBP3 LTBP3 FGF4 FGF4 INPPL1 INPPL1 SERPINH1 SERPINH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL27A1COL27A1 isoform 1. (1860 aa)
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2). (525 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
TMEM107Transmembrane protein 107. (146 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
NAB1NGFI-A binding protein 1 (EGR1 binding protein 1). (487 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NPPCNatriuretic peptide C. (126 aa)
PAX1PAX1 isoform 1. (457 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
CDX1CDX1 isoform 1. (265 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
TBXTT-box transcription factor T. (435 aa)
HOXA11HOXA11 isoform 2. (313 aa)
SFRP4SFRP4 isoform 1. (368 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
DLX5Distal-less homeobox 5. (289 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
STC1Stanniocalcin 1. (247 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CER1CER1 isoform 1. (267 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
COL13A1Collagen type XIII alpha 1 chain. (717 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SP5Sp5 transcription factor. (398 aa)
FREM1FREM1 isoform 1. (2179 aa)
RIPPLY2Ripply transcriptional repressor 2. (128 aa)
RARARARA isoform 4. (624 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
HAS2Hyaluronan synthase 2. (554 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FOXN3FOXN3 isoform 2. (490 aa)
ENSPTRP00000063945annotation not available (476 aa)
FOXC1FOXC1 isoform 1. (550 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TMEM107-2Transmembrane protein 107. (140 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
GLG1Golgi glycoprotein 1. (1203 aa)
ENSPTRP00000070794annotation not available (426 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
TMEM119Transmembrane protein 119. (283 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TIFABTIFAB isoform 1. (161 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
GHRGrowth hormone receptor. (645 aa)
ALPLAlkaline phosphatase. (524 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
MMP16Matrix metallopeptidase 16 (Membrane-inserted). (609 aa)
DCANP1LOW QUALITY PROTEIN: dendritic cell nuclear protein 1. (237 aa)
ENSPTRP00000075468annotation not available (220 aa)
MMP13Matrix metallopeptidase 13. (498 aa)
ENSPTRP00000077262annotation not available (314 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ANXA6Annexin. (788 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHOX2SHOX2 isoform 2. (343 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (869 aa)
ENSPTRP00000092702annotation not available (482 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
TWIST1TWIST1 isoform 2. (163 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
DHRS3Dehydrogenase/reductase (SDR family) member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
MATN1MATN1 isoform 1. (496 aa)
THBS3Thrombospondin 3. (956 aa)
PAPPA2PAPPA2 isoform 1. (1791 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
SERPINH1Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1); Belongs to the serpin family. (418 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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