33 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	BMP10	Bone morphogenetic protein 10. (424 aa)
	MAPK14	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	CDK1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1386 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	TGFBR3	Transforming growth factor, beta receptor III. (861 aa)
	BASP1	Brain abundant, membrane attached signal protein 1. (226 aa)
	IGF1	Insulin-like growth factor 1 (Somatomedin C). (196 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	ZFPM2	ZFPM2 isoform 3. (1151 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	ACACB	ACACB isoform 2. (2458 aa)
	CK820_G0015962	ACACB isoform 16. (191 aa)
	WT1	WT1 transcription factor. (514 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	NRG1	NRG1 isoform 3. (713 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	GATA6	GATA binding protein 6. (594 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	AKAP6	A-kinase anchoring protein 6. (2319 aa)
	PARP2	Poly [ADP-ribose] polymerase. (570 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	YAP1	Yes-associated protein 1. (508 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
	TBX20	T-box transcription factor 20. (447 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BASP1	WT1	ENSPTRP00000067678	ENSPTRP00000087673	Brain abundant, membrane attached signal protein 1.	WT1 transcription factor.	0.615
BMP10	BMPR1A	ENSPTRP00000078228	ENSPTRP00000004727	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.695
BMP10	ENSPTRP00000064416	ENSPTRP00000078228	ENSPTRP00000064416	Bone morphogenetic protein 10.	annotation not available	0.695
BMPR1A	BMP10	ENSPTRP00000004727	ENSPTRP00000078228	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.695
BMPR1A	TGFBR3	ENSPTRP00000004727	ENSPTRP00000066360	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor, beta receptor III.	0.424
CDK1	MAPK14	ENSPTRP00000050657	ENSPTRP00000030915	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.549
CDK1	YAP1	ENSPTRP00000050657	ENSPTRP00000007247	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Yes-associated protein 1.	0.499
EDN1	IGF1	ENSPTRP00000030273	ENSPTRP00000067917	EDN1 isoform 1.	Insulin-like growth factor 1 (Somatomedin C).	0.461
ENSPTRP00000064416	BMP10	ENSPTRP00000064416	ENSPTRP00000078228	annotation not available	Bone morphogenetic protein 10.	0.695
ENSPTRP00000064416	TGFBR3	ENSPTRP00000064416	ENSPTRP00000066360	annotation not available	Transforming growth factor, beta receptor III.	0.424
ERBB4	FGF9	ENSPTRP00000063299	ENSPTRP00000009715	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.717
ERBB4	IGF1	ENSPTRP00000063299	ENSPTRP00000067917	Receptor protein-tyrosine kinase.	Insulin-like growth factor 1 (Somatomedin C).	0.738
ERBB4	NOTCH1	ENSPTRP00000063299	ENSPTRP00000036924	Receptor protein-tyrosine kinase.	NOTCH1 isoform 1.	0.509
ERBB4	NRG1	ENSPTRP00000063299	ENSPTRP00000092088	Receptor protein-tyrosine kinase.	NRG1 isoform 3.	0.997
ERBB4	YAP1	ENSPTRP00000063299	ENSPTRP00000007247	Receptor protein-tyrosine kinase.	Yes-associated protein 1.	0.969
FGF9	ERBB4	ENSPTRP00000009715	ENSPTRP00000063299	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Receptor protein-tyrosine kinase.	0.717
FGF9	FGFR2	ENSPTRP00000009715	ENSPTRP00000005308	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.957
FGF9	IGF1	ENSPTRP00000009715	ENSPTRP00000067917	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin-like growth factor 1 (Somatomedin C).	0.652
FGFR2	FGF9	ENSPTRP00000005308	ENSPTRP00000009715	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.957
FGFR2	IGF1	ENSPTRP00000005308	ENSPTRP00000067917	Fibroblast growth factor receptor.	Insulin-like growth factor 1 (Somatomedin C).	0.470