STRINGSTRING
SHH SHH FGFR2 FGFR2 BMP4 BMP4 BMP4-2 BMP4-2 HOXB13 HOXB13 HOXD13 HOXD13 ESR1 ESR1 HOXA13-2 HOXA13-2 FRS2 FRS2 FEM1B FEM1B NKX3-1 NKX3-1 SFRP1 SFRP1 HOXA13 HOXA13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HOXB13HOXB13 isoform 1. (284 aa)
HOXD13HOXD13 isoform 1. (344 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
FEM1BFEM1B isoform 1. (627 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
HOXA13Homeobox A13. (388 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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