STRINGSTRING
ADPRHL2 ADPRHL2 FADD FADD BIRC2 BIRC2 YBX3 YBX3 RNF31 RNF31 RIPK3 RIPK3 CASP8 CASP8 RBCK1 RBCK1 SPATA2 SPATA2 RIPK1 RIPK1 CAV1 CAV1 CASP2 CASP2 PELI1 PELI1 FZD9 FZD9 LOC100614689 LOC100614689 OGT OGT ARHGEF2 ARHGEF2 CASP2-2 CASP2-2 MUTYH MUTYH CFLAR CFLAR CASP6 CASP6 CYLD CYLD ZBP1 ZBP1 SLC25A4 SLC25A4 BIRC3 BIRC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADPRHL2ADPRHL2 isoform 1. (364 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
YBX3Cold shock domain protein A. (374 aa)
RNF31T0103527 isoform 1. (1072 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CASP2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
OGTOGT isoform 6. (1057 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
CASP2-2Caspase 2. (452 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (612 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
CASP6Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
SLC25A4Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BIRC3Baculoviral IAP repeat containing 3. (610 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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