STRINGSTRING
NRP1 NRP1 TNN TNN LPAR3 LPAR3 EDN2 EDN2 RND2 RND2 EDN3 EDN3 DDR1 DDR1 ITGB1 ITGB1 ENSPTRP00000069764 ENSPTRP00000069764 NLGN3 NLGN3 CSF1 CSF1 NDEL1-2 NDEL1-2 ALCAM ALCAM DVL1 DVL1 TGFBR2 TGFBR2 KDM5B KDM5B SHH SHH ENSPTRP00000078533 ENSPTRP00000078533 CK820_G0040570 CK820_G0040570 LIMK1-2 LIMK1-2 SLIT2 SLIT2 SEMA3F SEMA3F ENSPTRP00000079980 ENSPTRP00000079980 CDK5 CDK5 BMP4-2 BMP4-2 SH3GL2 SH3GL2 NIN NIN IMPACT IMPACT COBL COBL SPRY1 SPRY1 RARG RARG LZTS2 LZTS2 JADE2 JADE2 SLIT1 SLIT1 DCLK1 DCLK1 FGF10 FGF10 ENSPTRP00000084830 ENSPTRP00000084830 AUTS2 AUTS2 MED12 MED12 SPG11 SPG11 WNT5A WNT5A PTK7 PTK7 LOC100615317 LOC100615317 PLXNA1 PLXNA1 CK820_G0040570-2 CK820_G0040570-2 ENSPTRP00000089676 ENSPTRP00000089676 ADPRHL1 ADPRHL1 LIMK1 LIMK1 ULK2 ULK2 ENSPTRP00000092743 ENSPTRP00000092743 CCL11 CCL11 APP APP USP9X USP9X SPAG6 SPAG6 DCX DCX TMEM108 TMEM108 NRN1 NRN1 CYFIP2 CYFIP2 PPP3CB PPP3CB SALL1 SALL1 TRIM28 TRIM28 FMN1 FMN1 WNT7B WNT7B IST1 IST1 SLC9A6 SLC9A6 EPB41L5 EPB41L5 S1PR1 S1PR1 AREG AREG BIN3 BIN3 EMX1 EMX1 LHX1 LHX1 SFRP1 SFRP1 MST1 MST1 WNT3A WNT3A KIF26B KIF26B RAPH1 RAPH1 FLRT1 FLRT1 WASF1 WASF1 CTNNB1 CTNNB1 SPART SPART PLXNA3 PLXNA3 HDAC6 HDAC6 SSNA1 SSNA1 NOTCH1 NOTCH1 LHX2 LHX2 C9H9orf72 C9H9orf72 EXT1 EXT1 RDH10 RDH10 SEMA3A SEMA3A MAGI2 MAGI2 ESR1 ESR1 HSP90AB1 HSP90AB1 SRF SRF EDN1 EDN1 SLIT3 SLIT3 POU4F3 POU4F3 FGF1 FGF1 CDKL3 CDKL3 EFNA5 EFNA5 MAP1B MAP1B SEMA5A SEMA5A SFRP2 SFRP2 EDNRA EDNRA POU4F2 POU4F2 RYK RYK SEMA5B SEMA5B LAMB2 LAMB2 CDH4 CDH4 AURKA AURKA FLRT3 FLRT3 NRP2 NRP2 ITGA4 ITGA4 HOXD13 HOXD13 TGFB1 TGFB1 STK11 STK11 SOX9 SOX9 TBX2 TBX2 MED1 MED1 NDEL1 NDEL1 NRN1L NRN1L IQGAP1 IQGAP1 MESP1 MESP1 SEMA7A SEMA7A PAK6 PAK6 EIF2AK4 EIF2AK4 CYFIP1 CYFIP1 BMP4 BMP4 SPRY2 SPRY2 RNF6 RNF6 LLPH LLPH YAP1 YAP1 WNT11 WNT11 FGFR2 FGFR2 VCL VCL TNR TNR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TNNTNN isoform 1. (1299 aa)
LPAR3Lysophosphatidic acid receptor 3. (353 aa)
EDN2EDN2 isoform 1. (178 aa)
RND2Rho family GTPase 2. (227 aa)
EDN3EDN3 isoform 1. (238 aa)
DDR1Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (920 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSPTRP00000069764annotation not available (1213 aa)
NLGN3NLGN3 isoform 5. (848 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
NDEL1-2NudE nuclear distribution gene E homolog-like 1. (351 aa)
ALCAMActivated leukocyte cell adhesion molecule. (590 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
KDM5BKDM5B isoform 2. (1580 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000078533annotation not available (144 aa)
CK820_G0040570PRKCZ isoform 2. (457 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
SEMA3FSEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
ENSPTRP00000079980annotation not available (129 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
NINNIN isoform 1. (2133 aa)
IMPACTIMPACT isoform 1. (320 aa)
COBLCordon-bleu WH2 repeat protein. (1333 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
JADE2Jade family PHD finger 2. (834 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPTRP00000084830annotation not available (340 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1259 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
SPG11SPG11 isoform 4. (2443 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
LOC100615317IST1 isoform 5. (331 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
CK820_G0040570-2PRKCZ isoform 4. (95 aa)
ENSPTRP00000089676annotation not available (850 aa)
ADPRHL1ADPRHL1 isoform 2. (1673 aa)
LIMK1LIM domain kinase 1. (677 aa)
ULK2Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1036 aa)
ENSPTRP00000092743annotation not available (379 aa)
CCL11C-C motif chemokine. (97 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
SPAG6Sperm associated antigen 6. (484 aa)
DCXDCX isoform 5. (420 aa)
TMEM108Transmembrane protein 108. (575 aa)
NRN1NRN1 isoform 3. (168 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
SALL1SALL1 isoform 2. (1326 aa)
TRIM28Tripartite motif containing 28. (835 aa)
FMN1FMN1 isoform 1. (1425 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
IST1IST1 factor associated with ESCRT-III. (376 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
AREGAREG isoform 2. (274 aa)
BIN3Bridging integrator 3. (253 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
KIF26BKIF26B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1302 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
HDAC6Histone deacetylase 6. (146 aa)
SSNA1Sjogren syndrome nuclear autoantigen 1. (119 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LHX2LHX2 isoform 1. (406 aa)
C9H9orf72Chromosome 9 open reading frame 72. (481 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
EDN1EDN1 isoform 1. (212 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
POU4F3POU domain, class 4, transcription factor 3. (338 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F2POU domain protein. (406 aa)
RYKReceptor like tyrosine kinase. (610 aa)
SEMA5BSEMA5B isoform 1. (1352 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
HOXD13HOXD13 isoform 1. (344 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TBX2T-box transcription factor 2. (712 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
NDEL1NudE nuclear distribution gene E homolog-like 1. (345 aa)
NRN1LNRN1L isoform 2. (165 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SPRY2Sprouty homolog 2. (338 aa)
RNF6Ring finger protein (C3H2C3 type) 6. (685 aa)
LLPHLLP homolog, long-term synaptic facilitation (Aplysia). (129 aa)
YAP1Yes-associated protein 1. (508 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
VCLVCL isoform 2. (1134 aa)
TNRTNR isoform 1. (1358 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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