8 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	NRG3	NRG3 isoform 3. (721 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	FGFR2	ENSPTRP00000010780	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4	TBX2	ENSPTRP00000010780	ENSPTRP00000016104	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.427
BMP4	TBX3	ENSPTRP00000010780	ENSPTRP00000084833	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.403
BMP4-2	FGF10	ENSPTRP00000080656	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4-2	FGFR2	ENSPTRP00000080656	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4-2	TBX2	ENSPTRP00000080656	ENSPTRP00000016104	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.427
BMP4-2	TBX3	ENSPTRP00000080656	ENSPTRP00000084833	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.403
FGF10	BMP4	ENSPTRP00000083399	ENSPTRP00000010780	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.696
FGF10	BMP4-2	ENSPTRP00000083399	ENSPTRP00000080656	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.696
FGF10	FGFR2	ENSPTRP00000083399	ENSPTRP00000005308	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.996
FGF10	GLI3	ENSPTRP00000083399	ENSPTRP00000032656	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.511
FGF10	TBX3	ENSPTRP00000083399	ENSPTRP00000084833	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	T-box transcription factor 3.	0.544
FGFR2	BMP4	ENSPTRP00000005308	ENSPTRP00000010780	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.492
FGFR2	BMP4-2	ENSPTRP00000005308	ENSPTRP00000080656	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.492
FGFR2	FGF10	ENSPTRP00000005308	ENSPTRP00000083399	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.996
GLI3	FGF10	ENSPTRP00000032656	ENSPTRP00000083399	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.511
TBX2	BMP4	ENSPTRP00000016104	ENSPTRP00000010780	T-box transcription factor 2.	Bone morphogenetic protein 4.	0.427
TBX2	BMP4-2	ENSPTRP00000016104	ENSPTRP00000080656	T-box transcription factor 2.	Bone morphogenetic protein 4.	0.427
TBX3	BMP4	ENSPTRP00000084833	ENSPTRP00000010780	T-box transcription factor 3.	Bone morphogenetic protein 4.	0.403