node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AREG | ESR1 | ENSPTRP00000061353 | ENSPTRP00000031932 | AREG isoform 2. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.509 |
AREG | SPRY2 | ENSPTRP00000061353 | ENSPTRP00000010120 | AREG isoform 2. | Sprouty homolog 2. | 0.490 |
AREG | TGFB1 | ENSPTRP00000061353 | ENSPTRP00000018930 | AREG isoform 2. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.460 |
BMP4 | FGF10 | ENSPTRP00000010780 | ENSPTRP00000083399 | Bone morphogenetic protein 4. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.696 |
BMP4 | FGFR2 | ENSPTRP00000010780 | ENSPTRP00000005308 | Bone morphogenetic protein 4. | Fibroblast growth factor receptor. | 0.492 |
BMP4 | SHH | ENSPTRP00000010780 | ENSPTRP00000075730 | Bone morphogenetic protein 4. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.720 |
BMP4 | SOX9 | ENSPTRP00000010780 | ENSPTRP00000016293 | Bone morphogenetic protein 4. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.509 |
BMP4 | WNT5A | ENSPTRP00000010780 | ENSPTRP00000086163 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.520 |
BMP4-2 | FGF10 | ENSPTRP00000080656 | ENSPTRP00000083399 | Bone morphogenetic protein 4. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.696 |
BMP4-2 | FGFR2 | ENSPTRP00000080656 | ENSPTRP00000005308 | Bone morphogenetic protein 4. | Fibroblast growth factor receptor. | 0.492 |
BMP4-2 | SHH | ENSPTRP00000080656 | ENSPTRP00000075730 | Bone morphogenetic protein 4. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.720 |
BMP4-2 | SOX9 | ENSPTRP00000080656 | ENSPTRP00000016293 | Bone morphogenetic protein 4. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.509 |
BMP4-2 | WNT5A | ENSPTRP00000080656 | ENSPTRP00000086163 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.520 |
ESR1 | AREG | ENSPTRP00000031932 | ENSPTRP00000061353 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | AREG isoform 2. | 0.509 |
ESR1 | FGF1 | ENSPTRP00000031932 | ENSPTRP00000029676 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.446 |
ESR1 | FGFR2 | ENSPTRP00000031932 | ENSPTRP00000005308 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Fibroblast growth factor receptor. | 0.581 |
ESR1 | MED1 | ENSPTRP00000031932 | ENSPTRP00000015490 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.996 |
ESR1 | SHH | ENSPTRP00000031932 | ENSPTRP00000075730 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.489 |
ESR1 | SOX9 | ENSPTRP00000031932 | ENSPTRP00000016293 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.412 |
ESR1 | TGFB1 | ENSPTRP00000031932 | ENSPTRP00000018930 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.468 |