(27 nodes) Embryonic placenta morphogenesis network (Pan troglodytes)

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Your Input:
	ENSPTRP00000089747	annotation not available (156 aa)
	CCN1	CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	ADM	Adrenomedullin. (185 aa)
	SPINT1	SPINT1 isoform 2. (529 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	RSPO3	RSPO3 isoform 1. (292 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	GJB5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	TRIM28	Tripartite motif containing 28. (835 aa)
	ZNF568	ZNF568 isoform 4. (675 aa)
	DNAJB6	DnaJ heat shock protein family (Hsp40) member B6. (334 aa)
	CK820_G0021556	TMED2 isoform 3. (200 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	TMED2	Transmembrane emp24 domain trafficking protein 2. (208 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	FGFR2	ENSPTRP00000023489	ENSPTRP00000005308	Bone morphogenetic protein 7.	Fibroblast growth factor receptor.	0.499
BMP7	LEF1	ENSPTRP00000023489	ENSPTRP00000079959	Bone morphogenetic protein 7.	Lymphoid enhancer binding factor 1.	0.473
FGFR2	BMP7	ENSPTRP00000005308	ENSPTRP00000023489	Fibroblast growth factor receptor.	Bone morphogenetic protein 7.	0.499
FGFR2	GRB2	ENSPTRP00000005308	ENSPTRP00000016382	Fibroblast growth factor receptor.	Growth factor receptor-bound protein 2.	0.882
FGFR2	LEF1	ENSPTRP00000005308	ENSPTRP00000079959	Fibroblast growth factor receptor.	Lymphoid enhancer binding factor 1.	0.447
FZD5	WNT7B	ENSPTRP00000021982	ENSPTRP00000063618	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.909
GRB2	FGFR2	ENSPTRP00000016382	ENSPTRP00000005308	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor.	0.882
GRB2	IGF2	ENSPTRP00000016382	ENSPTRP00000079014	Growth factor receptor-bound protein 2.	Insulin like growth factor 2.	0.538
IGF2	GRB2	ENSPTRP00000079014	ENSPTRP00000016382	Insulin like growth factor 2.	Growth factor receptor-bound protein 2.	0.538
IGF2	IL10	ENSPTRP00000079014	ENSPTRP00000003208	Insulin like growth factor 2.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.410
IL10	IGF2	ENSPTRP00000003208	ENSPTRP00000079014	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Insulin like growth factor 2.	0.410
IL10	SOCS3	ENSPTRP00000003208	ENSPTRP00000092362	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Suppressor of cytokine signaling 3.	0.703
LEF1	BMP7	ENSPTRP00000079959	ENSPTRP00000023489	Lymphoid enhancer binding factor 1.	Bone morphogenetic protein 7.	0.473
LEF1	FGFR2	ENSPTRP00000079959	ENSPTRP00000005308	Lymphoid enhancer binding factor 1.	Fibroblast growth factor receptor.	0.447
LEF1	WNT7B	ENSPTRP00000079959	ENSPTRP00000063618	Lymphoid enhancer binding factor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.518
SOCS3	IL10	ENSPTRP00000092362	ENSPTRP00000003208	Suppressor of cytokine signaling 3.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.703
SPINT1	ST14	ENSPTRP00000011835	ENSPTRP00000090494	SPINT1 isoform 2.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.980
ST14	SPINT1	ENSPTRP00000090494	ENSPTRP00000011835	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	SPINT1 isoform 2.	0.980
TRIM28	ZNF568	ENSPTRP00000064302	ENSPTRP00000068943	Tripartite motif containing 28.	ZNF568 isoform 4.	0.429
WNT7B	FZD5	ENSPTRP00000063618	ENSPTRP00000021982	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.909