STRINGSTRING
TGFB1 TGFB1 TACSTD2 TACSTD2 AGT AGT FGFR2 FGFR2 LRRK2 LRRK2 NTN4 NTN4 BMP4 BMP4 FGF7 FGF7 SOX8 SOX8 NOG NOG SOX9 SOX9 SIRT6 SIRT6 SIX2 SIX2 HOXD13 HOXD13 BMP7 BMP7 CAV3 CAV3 MAP3K13 MAP3K13 FKBPL FKBPL ESR1 ESR1 WNT2 WNT2 SMO SMO SNAI2 SNAI2 BCL11A BCL11A SIX4 SIX4 CTNNB1 CTNNB1 GDNF GDNF SFRP1 SFRP1 WNT2B WNT2B LHX1 LHX1 RTN4 RTN4 PGF PGF CK820_G0012168 CK820_G0012168 ENSPTRP00000063703 ENSPTRP00000063703 SMO-2 SMO-2 TNF TNF SIX1 SIX1 HGF HGF ABL1 ABL1 AGTR2 AGTR2 SULF1 SULF1 SHH SHH AR AR MAGED1 MAGED1 BMP4-2 BMP4-2 FGF10 FGF10 MDK MDK PAX8 PAX8 WNT5A WNT5A BTBD7 BTBD7 PAX2 PAX2 PHB2 PHB2 SHOX2 SHOX2 LGR4 LGR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
NTN4NTN4 isoform 3. (628 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SOX8SOX8 isoform 1. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SIRT6SIRT6 isoform 1. (355 aa)
SIX2SIX homeobox 2. (291 aa)
HOXD13HOXD13 isoform 1. (344 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
FKBPLFK506 binding protein like. (349 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (835 aa)
SIX4SIX homeobox 4. (781 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
RTN4Reticulon. (1192 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
ENSPTRP00000063703annotation not available (362 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SIX1SIX homeobox 1. (284 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
MAGED1MAGE family member D1. (834 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
PAX8PAX8 isoform 1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BTBD7BTB (POZ) domain containing 7. (1132 aa)
PAX2PAX2 isoform 1. (417 aa)
PHB2Prohibitin. (299 aa)
SHOX2SHOX2 isoform 2. (343 aa)
LGR4LGR4 isoform 2. (951 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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