STRINGSTRING
TMED2 TMED2 OVOL2 OVOL2 ENSPTRP00000089747 ENSPTRP00000089747 VASH1 VASH1 PLCD3 PLCD3 AKT1 AKT1 RBPJ RBPJ CK820_G0021556 CK820_G0021556 HEY1 HEY1 NSDHL-2 NSDHL-2 HES1 HES1 JUNB JUNB NSDHL NSDHL WNT2 WNT2 PLG PLG HEY2 HEY2 MAPK1 MAPK1 FZD5 FZD5 HS6ST1 HS6ST1 GGNBP2 GGNBP2 FBXW8 FBXW8 VASH2 VASH2 CCN1 CCN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
ENSPTRP00000089747annotation not available (156 aa)
VASH1VASH1 isoform 1. (365 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
GGNBP2Gametogenetin binding protein 2. (697 aa)
FBXW8F-box and WD repeat domain containing 8. (597 aa)
VASH2VASH2 isoform 6. (355 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.