STRINGSTRING
CCN1 CCN1 VASH2 VASH2 FBXW8 FBXW8 GGNBP2 GGNBP2 HS6ST1 HS6ST1 FZD5 FZD5 MAPK1 MAPK1 HEY2 HEY2 PLG PLG WNT2 WNT2 NSDHL NSDHL JUNB JUNB HES1 HES1 NSDHL-2 NSDHL-2 HEY1 HEY1 CK820_G0021556 CK820_G0021556 RBPJ RBPJ AKT1 AKT1 TMED2 TMED2 PLCD3 PLCD3 VASH1 VASH1 ENSPTRP00000089747 ENSPTRP00000089747 OVOL2 OVOL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
VASH2VASH2 isoform 6. (355 aa)
FBXW8F-box and WD repeat domain containing 8. (597 aa)
GGNBP2Gametogenetin binding protein 2. (697 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
VASH1VASH1 isoform 1. (365 aa)
ENSPTRP00000089747annotation not available (156 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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