11 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXB13	HOXB13 isoform 1. (284 aa)
	FEM1B	FEM1B isoform 1. (627 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	PSAP	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
	FOXA1	FOXA1 isoform 1. (471 aa)
	PSAPL1	Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	WDR77	Methylosome protein 50. (342 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSPTRP00000076864	ENSPTRP00000044466	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.960
AR	FOXA1	ENSPTRP00000076864	ENSPTRP00000062658	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	FOXA1 isoform 1.	0.959
AR	HOXB13	ENSPTRP00000076864	ENSPTRP00000015908	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	HOXB13 isoform 1.	0.678
AR	WDR77	ENSPTRP00000076864	ENSPTRP00000001898	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Methylosome protein 50.	0.450
CTNNB1	AR	ENSPTRP00000044466	ENSPTRP00000076864	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.960
CTNNB1	FGFR2	ENSPTRP00000044466	ENSPTRP00000005308	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Fibroblast growth factor receptor.	0.616
CTNNB1	FOXA1	ENSPTRP00000044466	ENSPTRP00000062658	Catenin (Cadherin-associated protein), beta 1, 88kDa.	FOXA1 isoform 1.	0.504
CTNNB1	NOTCH1	ENSPTRP00000044466	ENSPTRP00000036924	Catenin (Cadherin-associated protein), beta 1, 88kDa.	NOTCH1 isoform 1.	0.784
FGFR2	CTNNB1	ENSPTRP00000005308	ENSPTRP00000044466	Fibroblast growth factor receptor.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.616
FGFR2	NOTCH1	ENSPTRP00000005308	ENSPTRP00000036924	Fibroblast growth factor receptor.	NOTCH1 isoform 1.	0.568
FOXA1	AR	ENSPTRP00000062658	ENSPTRP00000076864	FOXA1 isoform 1.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.959
FOXA1	CTNNB1	ENSPTRP00000062658	ENSPTRP00000044466	FOXA1 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.504
FOXA1	HOXB13	ENSPTRP00000062658	ENSPTRP00000015908	FOXA1 isoform 1.	HOXB13 isoform 1.	0.557
HOXB13	AR	ENSPTRP00000015908	ENSPTRP00000076864	HOXB13 isoform 1.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.678
HOXB13	FOXA1	ENSPTRP00000015908	ENSPTRP00000062658	HOXB13 isoform 1.	FOXA1 isoform 1.	0.557
NOTCH1	CTNNB1	ENSPTRP00000036924	ENSPTRP00000044466	NOTCH1 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.784
NOTCH1	FGFR2	ENSPTRP00000036924	ENSPTRP00000005308	NOTCH1 isoform 1.	Fibroblast growth factor receptor.	0.568
PSAP	PSAPL1	ENSPTRP00000064944	ENSPTRP00000053714	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids.	0.901
PSAPL1	PSAP	ENSPTRP00000053714	ENSPTRP00000064944	Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.901
WDR77	AR	ENSPTRP00000001898	ENSPTRP00000076864	Methylosome protein 50.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.450