STRINGSTRING
PFDN5 PFDN5 LMBR1L LMBR1L WNT10B WNT10B LRRK2 LRRK2 YAP1 YAP1 FZD4 FZD4 WNT11 WNT11 FOLR1 FOLR1 FGFR2 FGFR2 HHEX HHEX TNKS2 TNKS2 DKK1 DKK1 BAMBI BAMBI SOX13 SOX13 LGR6 LGR6 TMEM9 TMEM9 TNN TNN RSPO1 RSPO1 NPPA NPPA DRAXIN DRAXIN MAD2L2 MAD2L2 FUZ FUZ ENSPTRP00000093714 ENSPTRP00000093714 SCEL SCEL LGR4 LGR4 ZEB2 ZEB2 FZD1-2 FZD1-2 CK820_G0008602 CK820_G0008602 NPHP4 NPHP4 ENSPTRP00000092852 ENSPTRP00000092852 CDH2 CDH2 LRRK1 LRRK1 ZBED3 ZBED3 CSNK1G3 CSNK1G3 ENSPTRP00000090863 ENSPTRP00000090863 NLE1 NLE1 HECW1 HECW1 SMAD3 SMAD3 CSNK1E CSNK1E OTULINL OTULINL DKK3 DKK3 CAPRIN2 CAPRIN2 ENSPTRP00000089297 ENSPTRP00000089297 SOSTDC1-2 SOSTDC1-2 SMURF2 SMURF2 FZD7 FZD7 APC2 APC2 PRICKLE1 PRICKLE1 FERMT1 FERMT1 FZD1 FZD1 PTK7 PTK7 ENSPTRP00000086277 ENSPTRP00000086277 CTNND1 CTNND1 WNT5A WNT5A ENSPTRP00000085846 ENSPTRP00000085846 MDK MDK EGR1 EGR1 ENSPTRP00000083999 ENSPTRP00000083999 PPM1N PPM1N ENSPTRP00000083721 ENSPTRP00000083721 FGF10 FGF10 FRMD8 FRMD8 LZTS2 LZTS2 LYPD6 LYPD6 CSNK1G1 CSNK1G1 CYLD CYLD MCC MCC EMD EMD LRP4 LRP4 CDK14-2 CDK14-2 TBL1XR1 TBL1XR1 GSK3B GSK3B TCF7L2 TCF7L2 CSNK1G2 CSNK1G2 ENSPTRP00000081300 ENSPTRP00000081300 FRAT1 FRAT1 STK3 STK3 LGR5 LGR5 RBPJ RBPJ CTNNBIP1 CTNNBIP1 ANKRD6 ANKRD6 ENSPTRP00000078462 ENSPTRP00000078462 SCYL2 SCYL2 LYPD6B LYPD6B PTPRO PTPRO CK820_G0051198 CK820_G0051198 GLI1 GLI1 LOC465674 LOC465674 G3BP1 G3BP1 IFT20 IFT20 ENSPTRP00000077377 ENSPTRP00000077377 TLE7 TLE7 CCNYL1 CCNYL1 ENSPTRP00000077105 ENSPTRP00000077105 BTRC BTRC SRC SRC CCNY CCNY WNK1 WNK1 HDAC1 HDAC1 ENSPTRP00000075783 ENSPTRP00000075783 ENSPTRP00000075757 ENSPTRP00000075757 SHH SHH TNKS TNKS BICC1 BICC1 DAAM2 DAAM2 GPRC5B GPRC5B SOX7 SOX7 XIAP XIAP AMFR AMFR WLS WLS ENSPTRP00000071968 ENSPTRP00000071968 USP34 USP34 TLE4 TLE4 DAB2 DAB2 PTPRU PTPRU TLE5 TLE5 CBY1 CBY1 FAM53B FAM53B PLEKHA4 PLEKHA4 JRK JRK EGFR EGFR ENSPTRP00000069619 ENSPTRP00000069619 RNF220 RNF220 NKD2 NKD2 USP8 USP8 ENSPTRP00000068492 ENSPTRP00000068492 WNK2 WNK2 GPC3 GPC3 JADE1 JADE1 ENSPTRP00000067847 ENSPTRP00000067847 SOSTDC1 SOSTDC1 ENSPTRP00000067619 ENSPTRP00000067619 CTNND2 CTNND2 SFRP5 SFRP5 LOC748850 LOC748850 ILK ILK ARNTL ARNTL CSNK1D CSNK1D CSNK1A1 CSNK1A1 RUVBL2 RUVBL2 DDX3X DDX3X RSPO2 RSPO2 CDK14 CDK14 ENSPTRP00000063212 ENSPTRP00000063212 STK4 STK4 MLLT3 MLLT3 PFDN5-2 PFDN5-2 ENSPTRP00000062193 ENSPTRP00000062193 CK820_G0042363 CK820_G0042363 TPBGL TPBGL ENSPTRP00000061866 ENSPTRP00000061866 CSNK1A1L CSNK1A1L USP47 USP47 DAB2IP DAB2IP APOE APOE PRDM15 PRDM15 AMER2 AMER2 NKD1 NKD1 UBAC2 UBAC2 SFRP1 SFRP1 SHISA6 SHISA6 NOTUM NOTUM ASPM ASPM RUVBL1 RUVBL1 WNT3A WNT3A TMEM170B TMEM170B SOX4 SOX4 KREMEN1 KREMEN1 GNAQ GNAQ TMEM198 TMEM198 DACT3 DACT3 FZD9 FZD9 AMER1 AMER1 SOX2 SOX2 TLE2 TLE2 LOC739971 LOC739971 TLE1 TLE1 WWTR1 WWTR1 CTNNB1 CTNNB1 NRARP NRARP FZD6 FZD6 DDIT3 DDIT3 KANK1 KANK1 AXIN1 AXIN1 SOX10 SOX10 EDA EDA OTUD5 OTUD5 ATP6AP2 ATP6AP2 NOTCH1 NOTCH1 INVS INVS RECK RECK VCP VCP CTHRC1 CTHRC1 UBR5 UBR5 TMEM64 TMEM64 SOX17 SOX17 SNAI2 SNAI2 DKK4 DKK4 ADGRA2 ADGRA2 ZNF703 ZNF703 CCAR2 CCAR2 CAV1 CAV1 DLX5 DLX5 IGFBP1 IGFBP1 GLI3 GLI3 SFRP4 SFRP4 PRKN PRKN LATS1 LATS1 RPS12 RPS12 RNF146 RNF146 RSPO3 RSPO3 TBX18 TBX18 TPBG TPBG MAPK14 MAPK14 NKX2-5 NKX2-5 APC APC ISL1 ISL1 OTULIN OTULIN SEMA5A SEMA5A SFRP2 SFRP2 TMEM131L TMEM131L EGF EGF DKK2 DKK2 NFKB1 NFKB1 SHISA3 SHISA3 SIAH2 SIAH2 PPP2R3A PPP2R3A KPNA1 KPNA1 LIMD1 LIMD1 RBMS3 RBMS3 RBX1 RBX1 ZNRF3 ZNRF3 GID8 GID8 BMP2 BMP2 FRZB FRZB TTC21B TTC21B AMER3 AMER3 PPM1B PPM1B DKKL1 DKKL1 TRPM4 TRPM4 GSK3A GSK3A TGFB1 TGFB1 PIN1 PIN1 DAPK3 DAPK3 TLE6 TLE6 STK11 STK11 SLC9A3R1 SLC9A3R1 SOX9 SOX9 AXIN2 AXIN2 MKS1 MKS1 NOG NOG COL1A1 COL1A1 SOST SOST JUP JUP IGFBP4 IGFBP4 TMEM88 TMEM88 CTDNEP1 CTDNEP1 CDH3 CDH3 VPS35 VPS35 MESP1 MESP1 TLE3 TLE3 GSKIP GSKIP CCDC88C CCDC88C PSEN1 PSEN1 PPM1A PPM1A DACT1 DACT1 CHD8 CHD8 GPC5 GPC5 FOXO1 FOXO1 FGF9 FGF9 LATS2 LATS2 PPP1CA PPP1CA CK820_G0016130 CK820_G0016130
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFDN5Prefoldin subunit 5. (154 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
YAP1Yes-associated protein 1. (508 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FOLR1Folate receptor alpha. (257 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
DKK1Dickkopf-like protein 1. (289 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SOX13SRY (Sex determining region Y)-box 13. (622 aa)
LGR6LGR6 isoform 2. (967 aa)
TMEM9Transmembrane protein 9. (183 aa)
TNNTNN isoform 1. (1299 aa)
RSPO1RSPO1 isoform 3. (263 aa)
NPPANatriuretic peptide A. (153 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
ENSPTRP00000093714annotation not available (142 aa)
SCELSCEL isoform 3. (688 aa)
LGR4LGR4 isoform 2. (951 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
CK820_G0008602USP8 isoform 7. (973 aa)
NPHP4NPHP4 isoform 5. (1426 aa)
ENSPTRP00000092852annotation not available (227 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
LRRK1Leucine-rich repeat kinase 1. (2015 aa)
ZBED3Zinc finger BED-type containing 3. (234 aa)
CSNK1G3Casein kinase 1, gamma 3; Belongs to the protein kinase superfamily. (455 aa)
ENSPTRP00000090863annotation not available (256 aa)
NLE1Notchless homolog 1. (485 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1608 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa)
OTULINLFAM105A isoform 2. (356 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (413 aa)
CAPRIN2Caprin family member 2. (1077 aa)
ENSPTRP00000089297annotation not available (265 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
APC2APC2 isoform 1. (2301 aa)
PRICKLE1PRICKLE1 isoform 11. (831 aa)
FERMT1Fermitin family member 1. (677 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
ENSPTRP00000086277annotation not available (106 aa)
CTNND1CTNND1 isoform 23. (975 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000085846annotation not available (426 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ENSPTRP00000083999annotation not available (92 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa)
ENSPTRP00000083721annotation not available (394 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRMD8FERM domain containing 8. (464 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
LYPD6LY6/PLAUR domain containing 6. (187 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
MCCColorectal mutant cancer protein isoform X6. (1015 aa)
EMDEMD isoform 1. (254 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
CDK14-2Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa)
TBL1XR1Transducin (Beta)-like 1 X-linked receptor 1. (562 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
CSNK1G2Casein kinase 1, gamma 2; Belongs to the protein kinase superfamily. (415 aa)
ENSPTRP00000081300annotation not available (154 aa)
FRAT1FRAT regulator of WNT signaling pathway 1. (279 aa)
STK3Serine/threonine kinase 3. (519 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
ENSPTRP00000078462annotation not available (221 aa)
SCYL2SCYL2 isoform 1. (962 aa)
LYPD6BLY6/PLAUR domain containing 6B. (241 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
CK820_G0051198TLE2 isoform 3. (113 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LOC465674LOW QUALITY PROTEIN: putative FERM domain-containing protein FRMD8P1. (452 aa)
G3BP1GTPase activating protein (SH3 domain) binding protein 1. (496 aa)
IFT20IFT20 isoform 5. (164 aa)
ENSPTRP00000077377annotation not available (149 aa)
TLE7TLE family member 7. (441 aa)
CCNYL1CCNYL1 isoform 3; Belongs to the cyclin family. (359 aa)
ENSPTRP00000077105annotation not available (129 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
SRCTyrosine-protein kinase. (542 aa)
CCNYCCNY isoform 4; Belongs to the cyclin family. (383 aa)
WNK1WNK1 isoform 4. (2833 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSPTRP00000075783annotation not available (149 aa)
ENSPTRP00000075757annotation not available (495 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
BICC1Bicaudal C homolog 1. (1074 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
GPRC5BG protein-coupled receptor, family C, group 5, member B. (421 aa)
SOX7SRY-box transcription factor 7. (388 aa)
XIAPBaculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (497 aa)
AMFRAutocrine motility factor receptor. (643 aa)
WLSWnt ligand secretion mediator. (543 aa)
ENSPTRP00000071968annotation not available (115 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3546 aa)
TLE4TLE family member 4, transcriptional corepressor. (805 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
TLE5AES isoform 1. (203 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
FAM53BFamily with sequence similarity 53, member B. (342 aa)
PLEKHA4Pleckstrin homology domain containing, family A (Phosphoinositide binding specific) member 4. (779 aa)
JRKJrk helix-turn-helix protein. (556 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ENSPTRP00000069619annotation not available (333 aa)
RNF220Ring finger protein 220. (566 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (464 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1110 aa)
ENSPTRP00000068492annotation not available (777 aa)
WNK2WNK2 isoform 4. (2235 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
JADE1Jade family PHD finger 1. (842 aa)
ENSPTRP00000067847annotation not available (809 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
ENSPTRP00000067619annotation not available (224 aa)
CTNND2CTNND2 isoform 2. (1250 aa)
SFRP5Secreted frizzled related protein 5. (317 aa)
LOC748850HDAC2 isoform 9. (445 aa)
ILKIntegrin-linked kinase. (533 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
CSNK1A1Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
RSPO2R-spondin 2 homolog. (243 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (451 aa)
ENSPTRP00000063212annotation not available (75 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MLLT3MLLT3 isoform 1. (570 aa)
PFDN5-2Prefoldin subunit 5. (127 aa)
ENSPTRP00000062193annotation not available (143 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
TPBGLTrophoblast glycoprotein like. (382 aa)
ENSPTRP00000061866annotation not available (267 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
PRDM15PRDM15 isoform 10. (1496 aa)
AMER2APC membrane recruitment protein 2. (552 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
UBAC2Phosphoglycerate dehydrogenase-like protein 1. (344 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
SHISA6Shisa family member 6. (551 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TMEM170BTransmembrane protein 170B. (132 aa)
SOX4Transcription factor SOX. (474 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
TMEM198Transmembrane protein 198. (360 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (181 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
AMER1APC membrane recruitment protein 1. (805 aa)
SOX2SRY-box transcription factor 2. (319 aa)
TLE2Transducin-like enhancer of split 2. (716 aa)
LOC739971Cyclin-Y-like protein 2. (358 aa)
TLE1Transducin-like enhancer of split 1. (814 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
KANK1KANK1 isoform 8. (1345 aa)
AXIN1AXIN1 isoform 2. (859 aa)
SOX10SRY-box transcription factor 10. (466 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
OTUD5OTU deubiquitinase 5. (598 aa)
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 2. (350 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
INVSINVS isoform 1. (1065 aa)
RECKReversion-inducing-cysteine-rich protein with kazal motifs. (965 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
TMEM64Transmembrane protein 64. (380 aa)
SOX17SOX17 isoform 1. (416 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (224 aa)
ADGRA2G protein-coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
ZNF703Zinc finger protein 703. (590 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
DLX5Distal-less homeobox 5. (289 aa)
IGFBP1IGFBP1 isoform 1. (281 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SFRP4SFRP4 isoform 1. (368 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
RNF146Ring finger protein 146. (359 aa)
RSPO3RSPO3 isoform 1. (292 aa)
TBX18T-box transcription factor 18. (607 aa)
TPBGTrophoblast glycoprotein. (420 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
APCAdenomatous polyposis coli protein isoform X10. (2844 aa)
ISL1ISL LIM homeobox 1. (349 aa)
OTULINOTULIN isoform 1. (352 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
TMEM131LTMEM131L isoform 3. (1617 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
SHISA3Shisa family member 3. (238 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
PPP2R3APPP2R3A isoform 1. (1150 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
LIMD1LIM domains containing 1. (676 aa)
RBMS3RNA binding motif, single stranded interacting protein 3. (437 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
ZNRF3ZNRF3 isoform 1. (920 aa)
GID8Chromosome 20 open reading frame 11. (228 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
FRZBFrizzled-related protein. (325 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
AMER3APC membrane recruitment protein 3. (861 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent, 1B. (479 aa)
DKKL1Dickkopf like acrosomal protein 1. (242 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
TLE6TLE family member 6, subcortical maternal complex member. (572 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
AXIN2AXIN2 isoform 1. (843 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
SOSTSOST isoform 1. (213 aa)
JUPJunction plakoglobin. (745 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
TMEM88Transmembrane protein 88. (159 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
CDH3Cadherin 3, type 1, P-cadherin (Placental); Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
TLE3TLE family member 3, transcriptional corepressor. (782 aa)
GSKIPChromosome 14 open reading frame 129. (139 aa)
CCDC88CCCDC88C isoform 3. (2028 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa)
GPC5GPC5 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)
FOXO1FOXO1 isoform 1. (655 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
CK820_G0016130SCYL2 isoform 5. (871 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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