STRINGSTRING
ROBO1 ROBO1 LDLR LDLR FGF8 FGF8 SHH SHH ADGRF5 ADGRF5 ENSPTRP00000076988 ENSPTRP00000076988 ACVR2B ACVR2B TFAP2B TFAP2B ENSPTRP00000078044 ENSPTRP00000078044 NPRL3 NPRL3 STRA6 STRA6 DCTN5 DCTN5 TAB1 TAB1 ROBO2 ROBO2 CK820_G0054677 CK820_G0054677 MYLK MYLK PRICKLE1 PRICKLE1 ENSPTRP00000087978 ENSPTRP00000087978 GJA5 GJA5 ENSPTRP00000085289 ENSPTRP00000085289 CITED2 CITED2 NKX3-1 NKX3-1 BMP4-2 BMP4-2 PDGFRB PDGFRB HOXA1-2 HOXA1-2 RBPJ RBPJ ANGPTL3 ANGPTL3 PRRX1 PRRX1 TGFB2 TGFB2 NRP1 NRP1 EGR2 EGR2 ZMIZ1 ZMIZ1 BMPR1A BMPR1A APLNR APLNR EFEMP2 EFEMP2 FOLR1 FOLR1 WNT11 WNT11 ARID2 ARID2 ACVRL1 ACVRL1 BMP4 BMP4 SMAD6 SMAD6 FOXF1 FOXF1 MYOCD MYOCD NF1 NF1 FKBP10 FKBP10 NGFR NGFR NOG NOG TBX2 TBX2 SMAD7 SMAD7 NOTCH3 NOTCH3 SNX17 SNX17 LRP2 LRP2 COL3A1 COL3A1 JAG1 JAG1 SLC2A10 SLC2A10 TBX1 TBX1 ADAMTS9 ADAMTS9 PLXND1 PLXND1 PKD2 PKD2 SEC24B SEC24B EDNRA EDNRA HPGD HPGD LOX LOX EDN1 EDN1 SRF SRF PRDM1 PRDM1 HEY2 HEY2 HOXA1 HOXA1 GLI3 GLI3 CHD7 CHD7 EYA1 EYA1 FOXH1 FOXH1 ENG ENG NOTCH1 NOTCH1 AP2B1 AP2B1 DDIT3 DDIT3 PDE2A PDE2A NDST1 NDST1 HOXA13-2 HOXA13-2 ADAMTS6 ADAMTS6 BMPR2 BMPR2 CNTRL CNTRL SOX4 SOX4 HAND2 HAND2 PROX1 PROX1 APOB APOB FOXH1-2 FOXH1-2 FOXC2 FOXC2 APOE APOE LOXL1 LOXL1 COMP COMP HECTD1 HECTD1 HOXA13 HOXA13 HES1 HES1 ENSPTRP00000064416 ENSPTRP00000064416 FOXC1 FOXC1 LOC736439 LOC736439 LUZP1 LUZP1 HEY1 HEY1 DLL4 DLL4 LRP1 LRP1 LEP LEP TGFBR1 TGFBR1 SUFU SUFU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROBO1Roundabout guidance receptor 1. (1684 aa)
LDLRLDLR isoform 7. (917 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
ENSPTRP00000076988annotation not available (871 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
ENSPTRP00000078044annotation not available (170 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
DCTN5Dynactin subunit 5. (182 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
CK820_G0054677NPRL3 isoform 10. (74 aa)
MYLKMYLK isoform 12. (1919 aa)
PRICKLE1PRICKLE1 isoform 11. (831 aa)
ENSPTRP00000087978annotation not available (470 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ENSPTRP00000085289annotation not available (322 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HOXA1-2Homeobox A1. (335 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
PRRX1Paired related homeobox 1. (245 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EGR2Early growth response 2. (476 aa)
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
EFEMP2EGF containing fibulin-like extracellular matrix protein 2. (443 aa)
FOLR1Folate receptor alpha. (257 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
FOXF1FOXF1 isoform 1. (433 aa)
MYOCDMYOCD isoform 2. (986 aa)
NF1Neurofibromin 1. (2839 aa)
FKBP10Peptidylprolyl isomerase. (582 aa)
NGFRNerve growth factor receptor. (427 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX2T-box transcription factor 2. (712 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
SNX17Sorting nexin 17. (470 aa)
LRP2LRP2 isoform 1. (4655 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SLC2A10Solute carrier family 2 (Facilitated glucose transporter), member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
TBX1TBX1 isoform 1. (478 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
SEC24BSEC24B isoform 1. (1286 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
LOXLOX isoform 1. (417 aa)
EDN1EDN1 isoform 1. (212 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
PRDM1PR/SET domain 1. (825 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
HOXA1HOXA1 isoform 2. (335 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CHD7CHD7 isoform 1. (2997 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
FOXH1FOXH1 isoform 1. (365 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AP2B1AP complex subunit beta. (951 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
PDE2APhosphodiesterase. (941 aa)
NDST1N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif, 6. (1117 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
SOX4Transcription factor SOX. (474 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PROX1Prospero homeobox 1. (737 aa)
APOBAPOB isoform 1. (4562 aa)
FOXH1-2Forkhead box H1. (365 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
LOXL1Lysyl oxidase-like 1. (577 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
HOXA13Homeobox A13. (388 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064416annotation not available (502 aa)
FOXC1FOXC1 isoform 1. (550 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
LRP1LDL receptor related protein 1. (4544 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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