STRINGSTRING
SNX17 SNX17 NRP1 NRP1 MMP21 MMP21 APLNR APLNR ARID2 ARID2 BMP4 BMP4 SPRED1 SPRED1 SMAD6 SMAD6 MESP1 MESP1 MYOCD MYOCD GATA6 GATA6 MEGF8 MEGF8 LRP2 LRP2 TBX1 TBX1 SETD2 SETD2 PLXND1 PLXND1 SEC24B SEC24B CPLANE1 CPLANE1 SRF SRF PRDM1 PRDM1 HEY2 HEY2 NOTCH1 NOTCH1 AP2B1 AP2B1 NDST1 NDST1 VEGFB VEGFB ADAMTS6 ADAMTS6 CNTRL CNTRL HAND2 HAND2 SGCD SGCD APELA APELA ZBTB14 ZBTB14 LOC736439 LOC736439 TGFBR3 TGFBR3 GPC3 GPC3 TBX5 TBX5 TGFBR1 TGFBR1 SUFU SUFU ENSPTRP00000075757 ENSPTRP00000075757 ENSPTRP00000076988 ENSPTRP00000076988 DYNC2H1 DYNC2H1 ENSPTRP00000078044 ENSPTRP00000078044 DCTN5 DCTN5 PDGFRB PDGFRB BMP4-2 BMP4-2 PTK7 PTK7 PRICKLE1 PRICKLE1 TAB1 TAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX17Sorting nexin 17. (470 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MMP21Matrix metallopeptidase 21. (569 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
MYOCDMYOCD isoform 2. (986 aa)
GATA6GATA binding protein 6. (594 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
LRP2LRP2 isoform 1. (4655 aa)
TBX1TBX1 isoform 1. (478 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
SEC24BSEC24B isoform 1. (1286 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
PRDM1PR/SET domain 1. (825 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AP2B1AP complex subunit beta. (951 aa)
NDST1N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif, 6. (1117 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SGCDSarcoglycan, delta (35kDa dystrophin-associated glycoprotein). (290 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
TBX5T-box transcription factor 5. (518 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
ENSPTRP00000075757annotation not available (495 aa)
ENSPTRP00000076988annotation not available (871 aa)
DYNC2H1DYNC2H1 isoform 4. (4314 aa)
ENSPTRP00000078044annotation not available (170 aa)
DCTN5Dynactin subunit 5. (182 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
PRICKLE1PRICKLE1 isoform 11. (831 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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