STRINGSTRING
SMAD3 SMAD3 ZNF219 ZNF219 CCN1 CCN1 ZBTB16 ZBTB16 SOX5 SOX5 ACVRL1 ACVRL1 BMP4 BMP4 SOX9 SOX9 SMAD7 SMAD7 GDF7 GDF7 PKDCC PKDCC BMP2 BMP2 GDF5 GDF5 MUSTN1 MUSTN1 BMPR1B BMPR1B SMAD1 SMAD1 BMP6 BMP6 HOXA11 HOXA11 GLI3 GLI3 POR-2 POR-2 BMP1 BMP1 SOX6 SOX6 BMPR2 BMPR2 TAPT1 TAPT1 RUNX2 RUNX2 LOXL2 LOXL2 POR-3 POR-3 GDF2 GDF2 ENSPTRP00000073126 ENSPTRP00000073126 SCX SCX GDF6 GDF6 ENSPTRP00000077262 ENSPTRP00000077262 BMP10 BMP10 BMP4-2 BMP4-2 MDK MDK WNT5A WNT5A FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (442 aa)
ZNF219Zinc finger protein 219. (722 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
SOX5SRY (Sex determining region Y)-box 5. (765 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
GDF7Growth differentiation factor 7. (447 aa)
PKDCCPKDCC isoform 1. (461 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GDF5GDF5 isoform 1. (501 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1 isoform X1. (87 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
POR-2NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
BMP1Metalloendopeptidase. (986 aa)
SOX6SOX6 isoform 9. (828 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
LOXL2LOXL2 isoform 4. (744 aa)
POR-3Cytochrome p450 oxidoreductase. (660 aa)
GDF2GDF2 isoform 1. (429 aa)
ENSPTRP00000073126annotation not available (296 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
GDF6Growth differentiation factor 6. (455 aa)
ENSPTRP00000077262annotation not available (314 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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