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HOXA13-2 HOXA13-2 ENSPTRP00000093474 ENSPTRP00000093474 CCL11 CCL11 SOCS3 SOCS3 FOXD1 FOXD1 PHB2 PHB2 COL4A1 COL4A1 PAX2 PAX2 ST14 ST14 FRS2 FRS2 BCL2 BCL2 ENSPTRP00000089747 ENSPTRP00000089747 LAMA5 LAMA5 NFATC4 NFATC4 DCHS1 DCHS1 PLXNA1 PLXNA1 WT1 WT1 PTCH1 PTCH1 HS3ST3A1 HS3ST3A1 BTBD7 BTBD7 NPNT NPNT WNT5A WNT5A LAMA1 LAMA1 PAX8 PAX8 TBX3 TBX3 KRAS KRAS VDR VDR TMED2 TMED2 CK820_G0054628 CK820_G0054628 FGF10 FGF10 MET MET ENSPTRP00000082912 ENSPTRP00000082912 SPRY1 SPRY1 FEM1B FEM1B NKX3-1 NKX3-1 BMP4-2 BMP4-2 ENSPTRP00000080279 ENSPTRP00000080279 LEF1 LEF1 SLIT2 SLIT2 WNT6 WNT6 CTNNBIP1 CTNNBIP1 CK820_G0021556 CK820_G0021556 ENSPTRP00000077262 ENSPTRP00000077262 BTRC BTRC AR AR SRC SRC ENSPTRP00000076491 ENSPTRP00000076491 WNT9B-2 WNT9B-2 ACVR1 ACVR1 SHH SHH KDM5B KDM5B FGF8 FGF8 TGFBR2 TGFBR2 NKX2-1 NKX2-1 DLL4 DLL4 SIX1 SIX1 CSF1 CSF1 ENSPTRP00000069764 ENSPTRP00000069764 DDR1 DDR1 GDF2 GDF2 GREB1L GREB1L LRP5 LRP5 FGF2 FGF2 CSMD1 CSMD1 DLG1 DLG1 ILK ILK SEMA3E SEMA3E CK820_G0056924 CK820_G0056924 SALL1 SALL1 RSPO2 RSPO2 ENSPTRP00000063703 ENSPTRP00000063703 HOXA13 HOXA13 WNT4 WNT4 STK4 STK4 FOXA1 FOXA1 PBX1 PBX1 AREG AREG WNT9B WNT9B PGF PGF CELSR1 CELSR1 NOTCH4 NOTCH4 HOXD11 HOXD11 LHX1 LHX1 FOXC2 FOXC2 SFRP1 SFRP1 CSMD2 CSMD2 PROX1 PROX1 GDNF GDNF CTNNB1 CTNNB1 NRARP NRARP CASR CASR TIMELESS TIMELESS SOX10 SOX10 HS3ST3B1 HS3ST3B1 GLI2 GLI2 CITED1 CITED1 NOTCH1 NOTCH1 ENG ENG EXT1 EXT1 GRHL2 GRHL2 RDH10 RDH10 EYA1 EYA1 SEMA3C SEMA3C GLI3 GLI3 TBX20 TBX20 HOXA11 HOXA11 HOXA5 HOXA5 ESR1 ESR1 TCF21 TCF21 RSPO3 RSPO3 GCM1 GCM1 PKHD1 PKHD1 SRF SRF EDN1 EDN1 FGF1 FGF1 ADAMTS16 ADAMTS16 SFRP2 SFRP2 EDNRA EDNRA HHIP HHIP EGF EGF PKD2 PKD2 KDR KDR TP63 TP63 PLXND1 PLXND1 DAG1 DAG1 LRP5L LRP5L CTSZ CTSZ BMP7 BMP7 TGM2 TGM2 GZF1 GZF1 BMP2 BMP2 GBX2 GBX2 IHH IHH FZD5 FZD5 HOXD13 HOXD13 RASIP1 RASIP1 TGFB1 TGFB1 TMEM59L TMEM59L SMAD4 SMAD4 GREB1 GREB1 GRB2 GRB2 SOX9 SOX9 GNA13 GNA13 TBX2 TBX2 MKS1 MKS1 NOG NOG HOXB13 HOXB13 MED1 MED1 FOXF1 FOXF1 ESRP2 ESRP2 SOX8 SOX8 CTSH CTSH PML PML FGF7 FGF7 SPINT1 SPINT1 BMP4 BMP4 MMP14 MMP14 SPRY2 SPRY2 PPP1CA PPP1CA WNT1 WNT1 YAP1 YAP1 PGR PGR PAK1 PAK1 ADM ADM FGFR2 FGFR2 DLG5 DLG5 NRP1 NRP1 IL10 IL10 RBM15 RBM15 TIE1 TIE1 CLIC4 CLIC4 EPHA2 EPHA2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA13-2HOXA13 isoform 1. (388 aa)
ENSPTRP00000093474Cadherin EGF LAG seven-pass G-type receptor 1. (124 aa)
CCL11C-C motif chemokine. (97 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
FOXD1FOXD1 isoform 1. (439 aa)
PHB2Prohibitin. (299 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PAX2PAX2 isoform 1. (417 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000089747annotation not available (156 aa)
LAMA5Laminin, alpha 5. (2203 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
WT1WT1 transcription factor. (514 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (374 aa)
BTBD7BTB (POZ) domain containing 7. (1132 aa)
NPNTNPNT isoform 10. (611 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
PAX8PAX8 isoform 1. (456 aa)
TBX3T-box transcription factor 3. (743 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ENSPTRP00000082912annotation not available (153 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
FEM1BFEM1B isoform 1. (627 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000080279annotation not available (270 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
ENSPTRP00000077262annotation not available (314 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000076491annotation not available (91 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
KDM5BKDM5B isoform 2. (1580 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
SIX1SIX homeobox 1. (284 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
ENSPTRP00000069764annotation not available (1213 aa)
DDR1Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (920 aa)
GDF2GDF2 isoform 1. (429 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
CSMD1CSMD1 isoform 2. (3565 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ILKIntegrin-linked kinase. (533 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
SALL1SALL1 isoform 2. (1326 aa)
RSPO2R-spondin 2 homolog. (243 aa)
ENSPTRP00000063703annotation not available (362 aa)
HOXA13Homeobox A13. (388 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
FOXA1FOXA1 isoform 1. (471 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
AREGAREG isoform 2. (274 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
CELSR1CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2998 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
HOXD11HOXD11 isoform 2. (339 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
CSMD2CUB and Sushi multiple domains 2. (3631 aa)
PROX1Prospero homeobox 1. (737 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
CASRCalcium sensing receptor. (1078 aa)
TIMELESSTimeless circadian regulator. (1209 aa)
SOX10SRY-box transcription factor 10. (466 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
GLI2GLI family zinc finger 2. (1587 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
TBX20T-box transcription factor 20. (447 aa)
HOXA11HOXA11 isoform 2. (313 aa)
HOXA5HOXA5 isoform 1. (270 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TCF21Transcription factor 21. (179 aa)
RSPO3RSPO3 isoform 1. (292 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
PKHD1PKHD1 isoform 1. (4074 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
EDN1EDN1 isoform 1. (212 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HHIPHedgehog interacting protein. (700 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
CTSZCTSZ isoform 1; Belongs to the peptidase C1 family. (303 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGM2Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
HOXD13HOXD13 isoform 1. (344 aa)
RASIP1Ras interacting protein 1. (963 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TMEM59LTransmembrane protein 59-like. (343 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GNA13Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
TBX2T-box transcription factor 2. (712 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXB13HOXB13 isoform 1. (284 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
FOXF1FOXF1 isoform 1. (433 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
SOX8SOX8 isoform 1. (446 aa)
CTSHCTSH isoform 11; Belongs to the peptidase C1 family. (335 aa)
PMLPML isoform 6. (836 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SPINT1SPINT1 isoform 2. (529 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
SPRY2Sprouty homolog 2. (338 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
YAP1Yes-associated protein 1. (508 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
ADMAdrenomedullin. (185 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
RBM15RNA binding motif protein 15. (977 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
EPHA2EPH receptor A2. (976 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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