STRINGSTRING
RERE RERE DMRTA2 DMRTA2 NDUFS2 NDUFS2 KIFAP3 KIFAP3 KIF14 KIF14 BTG2 BTG2 EMX2 EMX2 FGFR2 FGFR2 DAGLA DAGLA BBS1 BBS1 KCNA1 KCNA1 SOX5 SOX5 WNT1 WNT1 RACGAP1 RACGAP1 SLC39A5 SLC39A5 LHX5 LHX5 LNX2 LNX2 HIF1A HIF1A ELL3 ELL3 ZZEF1 ZZEF1 TP53 TP53 NF1 NF1 IGF2BP1 IGF2BP1 ATF5 ATF5 SIX3 SIX3 GBX2 GBX2 RYK RYK EGF EGF HHIP HHIP OTP OTP CEP120 CEP120 CTNNA1 CTNNA1 ORC3 ORC3 DIXDC1 DIXDC1 GLI3 GLI3 WNT2 WNT2 SMO SMO PCM1 PCM1 FZD3 FZD3 HOOK3 HOOK3 AKNA AKNA SOX10 SOX10 FZD6 FZD6 CTNNB1 CTNNB1 NUMB NUMB FZD9 FZD9 TARBP2 TARBP2 ZNF503 ZNF503 WNT3A WNT3A PROX1 PROX1 ASPM ASPM EML1 EML1 FOXG1 FOXG1 GATA2 GATA2 ADGRG1 ADGRG1 CTF2 CTF2 EPHB1 EPHB1 DAGLB-2 DAGLB-2 NEUROD4 NEUROD4 ENSPTRP00000063424 ENSPTRP00000063424 SHANK3 SHANK3 NUMBL NUMBL WNT7A WNT7A PAX6 PAX6 ENSPTRP00000065728 ENSPTRP00000065728 ILK ILK FGF13 FGF13 SMO-2 SMO-2 CDON CDON MELK MELK DRD2 DRD2 ITGB1 ITGB1 ARHGEF2 ARHGEF2 ARX ARX ID4 ID4 DOCK7 DOCK7 NR2E1 NR2E1 ENSPTRP00000073126 ENSPTRP00000073126 RPGRIP1 RPGRIP1 NDE1 NDE1 ENSPTRP00000074270 ENSPTRP00000074270 POU3F3 POU3F3 FGF8 FGF8 SHH SHH PLXNB2 PLXNB2 IFT20 IFT20 ASCL1 ASCL1 PAFAH1B1 PAFAH1B1 PSMG1 PSMG1 DISC1 DISC1 LEF1 LEF1 DCT DCT TMEM14B TMEM14B ENSPTRP00000081669 ENSPTRP00000081669 TEAD3 TEAD3 ARTN ARTN LIMS2 LIMS2 DAGLB DAGLB DBN1 DBN1 RORA RORA ACSL6 ACSL6 VAX1 VAX1 RAB10 RAB10 FRS2 FRS2 TRNP1 TRNP1 NR2E1-2 NR2E1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
REREArginine-glutamic acid dipeptide (RE) repeats. (1566 aa)
DMRTA2DMRT like family A2. (539 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (463 aa)
KIFAP3Kinesin-associated protein 3. (792 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
DAGLADiacylglycerol lipase, alpha. (1042 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
KCNA1Potassium voltage-gated channel, shaker-related subfamily, member 1 (Episodic ataxia with myokymia); Belongs to the potassium channel family. (495 aa)
SOX5SRY (Sex determining region Y)-box 5. (765 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
LHX5LHX5 isoform 2. (402 aa)
LNX2Ligand of numb-protein X 2. (690 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
ZZEF1ZZEF1 isoform 1. (2962 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NF1Neurofibromin 1. (2839 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ATF5ATF5 isoform 1. (282 aa)
SIX3SIX homeobox 3. (331 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
RYKReceptor like tyrosine kinase. (610 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
HHIPHedgehog interacting protein. (700 aa)
OTPOrthopedia homeobox. (325 aa)
CEP120Centrosomal protein 120kDa. (986 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
DIXDC1DIX domain containing 1. (683 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
PCM1Pericentriolar material 1. (2024 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
HOOK3Protein Hook homolog 3 isoform X2. (718 aa)
AKNAAT-hook transcription factor. (1440 aa)
SOX10SRY-box transcription factor 10. (466 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
ZNF503ZNF503 isoform 1. (647 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PROX1Prospero homeobox 1. (737 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
EML1EML1 isoform 2. (834 aa)
FOXG1FOXG1 isoform 8. (489 aa)
GATA2GATA binding protein 2. (480 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
CTF2Cardiotrophin-2; May have an important role in neuronal precursor development and maturation; Belongs to the IL-6 superfamily. (207 aa)
EPHB1EPH receptor B1. (984 aa)
DAGLB-2Diacylglycerol lipase, beta. (688 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
ENSPTRP00000063424annotation not available (1563 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
NUMBLNUMBL isoform 1. (611 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
PAX6PAX6 isoform 13. (436 aa)
ENSPTRP00000065728annotation not available (516 aa)
ILKIntegrin-linked kinase. (533 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
MELKNon-specific serine/threonine protein kinase. (651 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ARXARX isoform 1. (559 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2129 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
ENSPTRP00000073126annotation not available (296 aa)
RPGRIP1RPGR interacting protein 1. (1287 aa)
NDE1NudE nuclear distribution gene E homolog 1. (359 aa)
ENSPTRP00000074270annotation not available (297 aa)
POU3F3POU domain protein. (476 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PLXNB2PLXNB2 isoform 1. (1838 aa)
IFT20IFT20 isoform 5. (164 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
PSMG1Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2. (288 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
DCTDopachrome tautomerase. (552 aa)
TMEM14BT0060485 isoform 1. (151 aa)
ENSPTRP00000081669annotation not available (319 aa)
TEAD3TEA domain transcription factor 3. (435 aa)
ARTNARTN isoform 11. (235 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
DAGLBSn1-specific diacylglycerol lipase beta isoform X1. (413 aa)
DBN1DBN1 isoform 1. (695 aa)
RORARAR-related orphan receptor A. (555 aa)
ACSL6T0093412 isoform 1. (722 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
TRNP1TMF1-regulated nuclear protein 1. (227 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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