STRINGSTRING
EGR1 EGR1 GDF2 GDF2 CHRDL2 CHRDL2 CSF1 CSF1 HOXA3-2 HOXA3-2 IMPAD1 IMPAD1 ID4 ID4 LEP LEP ENSPTRP00000073126 ENSPTRP00000073126 SCX SCX SULF1 SULF1 HOXC4 HOXC4 MEF2D MEF2D GHR GHR COL5A1 COL5A1 TGFBR2 TGFBR2 MMP13 MMP13 ENSPTRP00000077036 ENSPTRP00000077036 ENSPTRP00000077262 ENSPTRP00000077262 GHRL GHRL LOC100612565 LOC100612565 ACCS ACCS ENSPTRP00000079262 ENSPTRP00000079262 ENSPTRP00000079733 ENSPTRP00000079733 GPR4 GPR4 PDGFRB PDGFRB SMAD5 SMAD5 SATB2 SATB2 ZMPSTE24 ZMPSTE24 ENSPTRP00000080279 ENSPTRP00000080279 EBF2 EBF2 HES5-2 HES5-2 BMP4-2 BMP4-2 ANXA6 ANXA6 TIMP1 TIMP1 SULF2 SULF2 TBL1XR1 TBL1XR1 ITGB8 ITGB8 RARB RARB RORC RORC RARG RARG SCUBE2 SCUBE2 CK820_G0054628 CK820_G0054628 OXCT1 OXCT1 CK820_G0045089 CK820_G0045089 PIK3CA PIK3CA ITGB8-2 ITGB8-2 SLC25A25-2 SLC25A25-2 FGF6 FGF6 TRPV4 TRPV4 WNT5A WNT5A PBXIP1 PBXIP1 HOXD3 HOXD3 ARID5B ARID5B ENSPTRP00000088770 ENSPTRP00000088770 COL11A1 COL11A1 FGFR3 FGFR3 ENSPTRP00000089565 ENSPTRP00000089565 ENSPTRP00000089584 ENSPTRP00000089584 CCN2 CCN2 ENSPTRP00000090255 ENSPTRP00000090255 MEF2C MEF2C MGP MGP CD44 CD44 FGF18 FGF18 SHOX2 SHOX2 FOXD1 FOXD1 CHST11 CHST11 ENSPTRP00000092702 ENSPTRP00000092702 RUNX1 RUNX1 FTO FTO OSR2 OSR2 SIX2 SIX2 EIF2AK3 EIF2AK3 ARID5A ARID5A DLX2 DLX2 COL3A1 COL3A1 IHH IHH NPPC NPPC BMP2 BMP2 MKKS MKKS GDF5 GDF5 BMP7 BMP7 UMODL1 UMODL1 CBS CBS LRP5L LRP5L PDGFB PDGFB PTH1R PTH1R HYAL3 HYAL3 HYAL1 HYAL1 MUSTN1 MUSTN1 IFT80 IFT80 CYTL1 CYTL1 PPARGC1A PPARGC1A BMP3 BMP3 BMPR1B BMPR1B PGRMC2 PGRMC2 SMAD1 SMAD1 SFRP2 SFRP2 ARRDC3 ARRDC3 LOX LOX PITX1 PITX1 HAND1 HAND1 BMP6 BMP6 EDN1 EDN1 GPLD1 GPLD1 MAPK14 MAPK14 SRF SRF IL17F IL17F BMP5 BMP5 HOXA5 HOXA5 HOXA11 HOXA11 GLI3 GLI3 CREB3L2 CREB3L2 BMP1 BMP1 STC1 STC1 SNAI2 SNAI2 VPS13B VPS13B EXT1 EXT1 CCN3 CCN3 CER1 CER1 OGN OGN COL27A1 COL27A1 NOTCH1 NOTCH1 CDK4 CDK4 HES5 HES5 SPART SPART COL2A1 COL2A1 BGN BGN CASR CASR SOX6 SOX6 DDRGK1 DDRGK1 PPARD PPARD CTNNB1 CTNNB1 RXFP1 RXFP1 HYAL2 HYAL2 AMER1 AMER1 TSKU TSKU BMPR2 BMPR2 SLC25A25 SLC25A25 HAND2 HAND2 HMGA2 HMGA2 OTOR OTOR RARA RARA FOXC2 FOXC2 MAPK3 MAPK3 EVC EVC WNT2B WNT2B CRIP1 CRIP1 MSX1 MSX1 TAPT1 TAPT1 AMELX AMELX PAXIP1 PAXIP1 BBS4 BBS4 COMP COMP SELENOM SELENOM NFIB NFIB ADAMTS12 ADAMTS12 ENSPTRP00000062206 ENSPTRP00000062206 SH3PXD2B SH3PXD2B FOXA1 FOXA1 ENSPTRP00000062696 ENSPTRP00000062696 ZEB1 ZEB1 HOXB3 HOXB3 LOC104003639 LOC104003639 WNT7B WNT7B ATF2 ATF2 RSPO2 RSPO2 DYRK1B DYRK1B SLC39A14 SLC39A14 ATP7A ATP7A ENSPTRP00000064416 ENSPTRP00000064416 CK820_G0056924 CK820_G0056924 UNCX UNCX WNT7A WNT7A SNORC SNORC XBP1 XBP1 TGFBI TGFBI RUNX2 RUNX2 SNAI1 SNAI1 HOXA3 HOXA3 SLC39A13 SLC39A13 COL11A2 COL11A2 LRP5 LRP5 PUM2 PUM2 MATN3 MATN3 OSR1 OSR1 TGFB1 TGFB1 ZNF516 ZNF516 MEX3C MEX3C TWSG1 TWSG1 TYMS TYMS SOX9 SOX9 AXIN2 AXIN2 NOG NOG COL1A1 COL1A1 THRA THRA DHRS7B DHRS7B SMPD3 SMPD3 BBS2 BBS2 SOX8 SOX8 ADAMTS7 ADAMTS7 TRIP11 TRIP11 SPTLC2 SPTLC2 HIF1A HIF1A BMP4 BMP4 CNMD CNMD RB1 RB1 FGF9 FGF9 EPYC EPYC MYF5 MYF5 WNT10B WNT10B SOX5 SOX5 WNT5B WNT5B SNX19 SNX19 BARX2 BARX2 ZBTB16 ZBTB16 ACAT1 ACAT1 DGAT2 DGAT2 SERPINH1 SERPINH1 FGF4 FGF4 BBS1 BBS1 LTBP3 LTBP3 ESRRA ESRRA HRAS HRAS BMPR1A BMPR1A CD34 CD34 CHI3L1 CHI3L1 RASAL2 RASAL2 PRRX1 PRRX1 THBS3 THBS3 ECM1 ECM1 HMGCS2 HMGCS2 CCN1 CCN1 BMP8B BMP8B ENSPTRP00000000998 ENSPTRP00000000998 MATN1 MATN1 RUNX3 RUNX3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
GDF2GDF2 isoform 1. (429 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
HOXA3-2Homeobox A3. (443 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ENSPTRP00000073126annotation not available (296 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
HOXC4HOXC4 isoform 1. (264 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
GHRGrowth hormone receptor. (645 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
MMP13Matrix metallopeptidase 13. (498 aa)
ENSPTRP00000077036annotation not available (396 aa)
ENSPTRP00000077262annotation not available (314 aa)
GHRLGHRL isoform 10. (117 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
ENSPTRP00000079262annotation not available (866 aa)
ENSPTRP00000079733annotation not available (1251 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SATB2DNA-binding protein SATB. (733 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
ENSPTRP00000080279annotation not available (270 aa)
EBF2EBF transcription factor 2. (575 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ANXA6Annexin. (788 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
TBL1XR1Transducin (Beta)-like 1 X-linked receptor 1. (562 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RORCRAR related orphan receptor C. (525 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (557 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
SLC25A25-2Solute carrier family 25 member 25. (515 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PBXIP1Pre-B-cell leukemia homeobox interacting protein 1. (731 aa)
HOXD3HOXD3 isoform 3. (432 aa)
ARID5BARID5B isoform 1. (1187 aa)
ENSPTRP00000088770annotation not available (124 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
ENSPTRP00000089565annotation not available (801 aa)
ENSPTRP00000089584annotation not available (842 aa)
CCN2CTGF isoform 1. (349 aa)
ENSPTRP00000090255annotation not available (356 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
CD44CD44 isoform 3. (742 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHOX2SHOX2 isoform 2. (343 aa)
FOXD1FOXD1 isoform 1. (439 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ENSPTRP00000092702annotation not available (482 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (559 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
SIX2SIX homeobox 2. (291 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
ARID5AAT rich interactive domain 5A (MRF1-like). (594 aa)
DLX2Distal-less homeobox 2. (328 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NPPCNatriuretic peptide C. (126 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
UMODL1UMODL1 isoform 3. (1445 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
HYAL3Hyaluronidase-3 precursor. (417 aa)
HYAL1Hyaluronidase. (435 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1 isoform X1. (87 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
CYTL1CYTL1 isoform 1. (136 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
ARRDC3Arrestin domain containing 3. (414 aa)
LOXLOX isoform 1. (417 aa)
PITX1Homeobox protein. (314 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
EDN1EDN1 isoform 1. (212 aa)
GPLD1GPLD1 isoform 2. (840 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
IL17FIL17F isoform 1. (199 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
HOXA5HOXA5 isoform 1. (270 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
BMP1Metalloendopeptidase. (986 aa)
STC1Stanniocalcin 1. (247 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
VPS13BVacuolar protein sorting 13 homolog B. (863 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CCN3NOV isoform 1. (357 aa)
CER1CER1 isoform 1. (267 aa)
OGNOGN isoform 2. (298 aa)
COL27A1COL27A1 isoform 1. (1860 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (376 aa)
CASRCalcium sensing receptor. (1078 aa)
SOX6SOX6 isoform 9. (828 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
RXFP1RXFP1 isoform 5. (779 aa)
HYAL2Hyaluronidase. (473 aa)
AMER1APC membrane recruitment protein 1. (805 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (515 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
OTOROTOR isoform 1. (128 aa)
RARARARA isoform 4. (624 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EVCEVC isoform 1. (991 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CRIP1Cysteine-rich protein 1 (Intestinal). (77 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
AMELXAmelogenin X-linked. (205 aa)
PAXIP1PAX interacting protein 1. (1067 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
SELENOMSelenoprotein M precursor. (144 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
ENSPTRP00000062206annotation not available (69 aa)
SH3PXD2BSH3 and PX domains 2B. (911 aa)
FOXA1FOXA1 isoform 1. (471 aa)
ENSPTRP00000062696annotation not available (320 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
HOXB3HOXB3 isoform 13. (431 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RSPO2R-spondin 2 homolog. (243 aa)
DYRK1BDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (629 aa)
SLC39A14SLC39A14 isoform 1. (490 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
ENSPTRP00000064416annotation not available (502 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
UNCXUNCX isoform 1. (531 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (121 aa)
XBP1XBP1 isoform 4. (381 aa)
TGFBITransforming growth factor, beta-induced, 68kDa. (706 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HOXA3HOXA3 isoform 3. (443 aa)
SLC39A13Solute carrier family 39 (Zinc transporter), member 13. (364 aa)
COL11A2COL11A2 isoform 2. (1736 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
PUM2Pumilio RNA binding family member 2. (1065 aa)
MATN3MATN3 isoform 1. (486 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ZNF516Zinc finger protein 516. (1163 aa)
MEX3CMEX3C isoform 2. (639 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TYMSThymidylate synthetase. (313 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
AXIN2AXIN2 isoform 1. (843 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
THRAThyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian). (617 aa)
DHRS7BDHRS7B isoform 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SOX8SOX8 isoform 1. (446 aa)
ADAMTS7ADAMTS7 isoform 1. (932 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
SPTLC2Serine palmitoyltransferase, long chain base subunit 2. (564 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CNMDCNMD isoform 4. (334 aa)
RB1RB transcriptional corepressor 1. (928 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EPYCEPYC isoform 1. (322 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SOX5SRY (Sex determining region Y)-box 5. (765 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SNX19Sorting nexin 19. (992 aa)
BARX2BARX homeobox 2. (279 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
SERPINH1Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1); Belongs to the serpin family. (418 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CD34CD34 isoform 1. (328 aa)
CHI3L1Chitinase 3-like 1 (Cartilage glycoprotein-39); Belongs to the glycosyl hydrolase 18 family. (383 aa)
RASAL2RAS protein activator like 2. (1280 aa)
PRRX1Paired related homeobox 1. (245 aa)
THBS3Thrombospondin 3. (956 aa)
ECM1Extracellular matrix protein 1. (540 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
BMP8BBMP8B isoform 1. (402 aa)
ENSPTRP00000000998annotation not available (224 aa)
MATN1MATN1 isoform 1. (496 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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