STRINGSTRING
NPPB NPPB PGLYRP3 PGLYRP3 PGLYRP4 PGLYRP4 S100A9 S100A9 S100A12 S100A12 ADM ADM F2 F2 GAPDH GAPDH NTS NTS PLA2G1B PLA2G1B RNASE6 RNASE6 LGALS3 LGALS3 NOD2 NOD2 CCL8 CCL8 CCL1 CCL1 ELANE ELANE CCL25 CCL25 HAMP HAMP LGALS4 LGALS4 PGLYRP1 PGLYRP1 REG1B REG1B REG3A REG3A DEFB126 DEFB126 DEFB127 DEFB127 BPIFA1 BPIFA1 BPI BPI SEMG1 SEMG1 LTF LTF CAMP CAMP HRG HRG HTN1 HTN1 MUC7 MUC7 CXCL6 CXCL6 CXCL1 CXCL1 PF4 PF4 PPBP PPBP CXCL5 CXCL5 CXCL3 CXCL3 CXCL9 CXCL9 CXCL10 CXCL10 CXCL11 CXCL11 CXCL13 CXCL13 CXCL14 CXCL14 LOC462501 LOC462501 H2BC11 H2BC11 DEFB1 DEFB1 DEFA4 DEFA4 SPAG11B SPAG11B RPL30 RPL30 CCL27 CCL27 CCL21 CCL21 TOR2A TOR2A GALP GALP S100A7L2 S100A7L2 DMBT1 DMBT1 CCL20 CCL20 ROMO1 ROMO1 LEAP2-2 LEAP2-2 H2BC21 H2BC21 REG3G REG3G POMC POMC HTN3 HTN3 CCL18 CCL18 LOC100614664 LOC100614664 DCD DCD FAU FAU CALCA CALCA RNASE7 RNASE7 CCL13 CCL13 KNG1 KNG1 ANG ANG DEFB118 DEFB118 CXCL12 CXCL12 FAM3A FAM3A S100A7A S100A7A LOC471880 LOC471880 LOC471883 LOC471883 DEFA5 DEFA5 DEFB4A DEFB4A LEAP2 LEAP2 TSLP TSLP ENSPTRP00000074115 ENSPTRP00000074115 LOC471883-2 LOC471883-2 CCL28 CCL28 S100A7 S100A7 CCL22 CCL22 PF4V1 PF4V1 LOC107973208 LOC107973208 GNLY GNLY CXCL2 CXCL2 ENSPTRP00000081286 ENSPTRP00000081286 ROMO1-2 ROMO1-2 RPL39 RPL39 CCL17 CCL17 DEFB131A-2 DEFB131A-2 TAC1 TAC1 ENSPTRP00000086424 ENSPTRP00000086424 DEFA6 DEFA6 ENSPTRP00000088103 ENSPTRP00000088103 RPS19 RPS19 LOC468581 LOC468581 ENSPTRP00000091039 ENSPTRP00000091039 H2BC6 H2BC6 CCL11 CCL11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPPBNatriuretic peptide B. (134 aa)
PGLYRP3PGLYRP3 isoform 1. (341 aa)
PGLYRP4PGLYRP4 isoform 2. (373 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
ADMAdrenomedullin. (185 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
NTSNTS isoform 1. (170 aa)
PLA2G1BPhospholipase A(2). (148 aa)
RNASE6Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. (150 aa)
LGALS3Galectin. (250 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
CCL8C-C motif chemokine. (109 aa)
CCL1C-C motif chemokine. (96 aa)
ELANEElastase, neutrophil expressed. (267 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
LGALS4Galectin. (323 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
REG1BRegenerating family member 1 beta. (166 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (108 aa)
DEFB127Beta-defensin 127; Has antibacterial activity; Belongs to the beta-defensin family. (99 aa)
BPIFA1BPI fold containing family A member 1. (256 aa)
BPIBactericidal permeability increasing protein. (489 aa)
SEMG1SEMG1 isoform 1. (463 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
CAMPCathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
HRGHistidine rich glycoprotein. (525 aa)
HTN1HTN1 isoform 1. (57 aa)
MUC7Mucin 7, secreted. (354 aa)
CXCL6C-X-C motif chemokine. (114 aa)
CXCL1C-X-C motif chemokine. (107 aa)
PF4C-X-C motif chemokine. (101 aa)
PPBPC-X-C motif chemokine. (128 aa)
CXCL5C-X-C motif chemokine. (114 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CXCL10C-X-C motif chemokine. (96 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL13C-X-C motif chemokine. (109 aa)
CXCL14Chemokine (C-X-C motif) ligand 14. (111 aa)
LOC462501HIST1H2BK isoform 1. (126 aa)
H2BC11HIST1H2BJ isoform 1. (126 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
DEFA4Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity). (97 aa)
SPAG11BSperm-associated antigen 11; Belongs to the SPAG11 family. (113 aa)
RPL30Ribosomal protein L30. (115 aa)
CCL27C-C motif chemokine ligand 27. (112 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
TOR2ATorsin. (321 aa)
GALPGalanin like peptide. (116 aa)
S100A7L2S100 calcium binding protein A7 like 2. (112 aa)
DMBT1DMBT1 isoform 2. (2148 aa)
CCL20C-C motif chemokine. (96 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
LEAP2-2Liver enriched antimicrobial peptide 2. (77 aa)
H2BC21HIST2H2BE isoform 1. (126 aa)
REG3GRegenerating islet-derived protein 3-gamma. (174 aa)
POMCProopiomelanocortin. (268 aa)
HTN3HTN3 isoform 1. (51 aa)
CCL18C-C motif chemokine. (89 aa)
LOC100614664Ribosomal protein L39 pseudogene. (51 aa)
DCDDCD isoform 2. (120 aa)
FAU40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (136 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
RNASE7Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
CCL13C-C motif chemokine. (98 aa)
KNG1KNG1 isoform 2. (644 aa)
ANGAngiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (147 aa)
DEFB118Beta-defensin 118; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
FAM3AFamily with sequence similarity 3 member A. (244 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
LOC471880Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC471883Histone H2B type 1. (126 aa)
DEFA5Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family. (94 aa)
DEFB4ABeta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily. (64 aa)
LEAP2Liver enriched antimicrobial peptide 2. (77 aa)
TSLPTSLP isoform 1. (159 aa)
ENSPTRP00000074115annotation not available (54 aa)
LOC471883-2Histone H2B type 1. (126 aa)
CCL28C-C motif chemokine. (127 aa)
S100A7Protein S100; Belongs to the S-100 family. (101 aa)
CCL22C-C motif chemokine. (93 aa)
PF4V1C-X-C motif chemokine. (104 aa)
LOC107973208Neutrophil defensin 1; Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (By similarity); Belongs to the alpha-defensin family. (94 aa)
GNLYGNLY isoform 8. (173 aa)
CXCL2C-X-C motif chemokine. (117 aa)
ENSPTRP00000081286annotation not available (61 aa)
ROMO1-2Reactive oxygen species modulator 1. (79 aa)
RPL39RPL39 isoform 3. (51 aa)
CCL17C-C motif chemokine. (94 aa)
DEFB131A-2Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
TAC1TAC1 isoform 1. (134 aa)
ENSPTRP00000086424annotation not available (98 aa)
DEFA6Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria; Belongs to the alpha-defensin family. (100 aa)
ENSPTRP00000088103annotation not available (56 aa)
RPS19Ribosomal protein S19. (145 aa)
LOC468581ubiquitin-60S ribosomal protein L40-like. (130 aa)
ENSPTRP00000091039annotation not available (117 aa)
H2BC6Histone H2B type 1. (126 aa)
CCL11C-C motif chemokine. (97 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.