STRINGSTRING
TXLNG TXLNG MATN1 MATN1 CCN1 CCN1 ECM1 ECM1 BGLAP BGLAP DDR2 DDR2 SRGN SRGN BMPR1A BMPR1A PTH PTH NELL1 NELL1 LTBP3 LTBP3 MMP20 MMP20 FGF23 FGF23 WNT10B WNT10B CYP27B1 CYP27B1 KL KL BMP4 BMP4 HIF1A HIF1A TGFB3 TGFB3 RFLNB RFLNB PHOSPHO1 PHOSPHO1 SOX9 SOX9 TGFB1 TGFB1 TRPM4 TRPM4 OSR1 OSR1 ATRAID ATRAID PKDCC PKDCC ACVR2A ACVR2A BMP2 BMP2 BMP7 BMP7 ATF4 ATF4 LTF LTF AHSG AHSG STATH STATH AMTN AMTN DMP1 DMP1 BMPR1B BMPR1B ADGRV1 ADGRV1 ADRB2 ADRB2 BMP6 BMP6 RXRB RXRB HEY2 HEY2 FBXO5 FBXO5 CFTR CFTR NOS3 NOS3 SLC4A2 SLC4A2 PTK2B PTK2B OMD OMD ASPN ASPN NOTCH1 NOTCH1 BCOR BCOR ATP2B1 ATP2B1 RXRA RXRA CK820_G0054574 CK820_G0054574 FZD9 FZD9 TWIST1 TWIST1 IFITM5 IFITM5 BMPR2 BMPR2 ENPP1 ENPP1 RFLNA RFLNA P2RX7 P2RX7 NOTUM NOTUM BMP2K BMP2K TXLNGY TXLNGY CK820_G0015936 CK820_G0015936 PHOSPHO2 PHOSPHO2 AMELX AMELX COMP COMP ENSPTRP00000060558 ENSPTRP00000060558 ODAPH ODAPH ISG15 ISG15 S1PR1 S1PR1 CK820_G0042363 CK820_G0042363 ENSPTRP00000062265 ENSPTRP00000062265 WNT4 WNT4 ROCK2 ROCK2 SLC8A1 SLC8A1 ENSPTRP00000064416 ENSPTRP00000064416 ANO6 ANO6 TENT5A TENT5A SGMS2 SGMS2 ALOX5 ALOX5 HEY1 HEY1 NBR1 NBR1 LOC100611078 LOC100611078 TMEM119 TMEM119 GPM6B GPM6B ENSPTRP00000075468 ENSPTRP00000075468 ACVR1 ACVR1 ACVR2B ACVR2B CCR1 CCR1 BCOR-2 BCOR-2 LOC745935 LOC745935 WNT6 WNT6 ZMPSTE24 ZMPSTE24 PTN PTN BMP4-2 BMP4-2 ENSPTRP00000082515 ENSPTRP00000082515 ENAM ENAM CEBPB CEBPB ACTN3 ACTN3 ANKH ANKH ENSPTRP00000086525 ENSPTRP00000086525 GATA1 GATA1 ENSPTRP00000087425 ENSPTRP00000087425 TFAP2A TFAP2A MEF2C MEF2C MGP MGP SMAD3 SMAD3 FBN2 FBN2 OSR2 OSR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TXLNGTXLNG isoform 1. (561 aa)
MATN1MATN1 isoform 1. (496 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ECM1Extracellular matrix protein 1. (540 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SRGNSRGN isoform 1. (162 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NELL1Neural EGFL like 1. (838 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
KLKL isoform 1. (1012 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RFLNBRFLNB isoform 1. (144 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
PKDCCPKDCC isoform 1. (461 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
AHSGAlpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family. (368 aa)
STATHSTATH isoform 1. (62 aa)
AMTNAMTN isoform 1. (209 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (513 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ADGRV1ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
RXRBRetinoid X receptor, beta. (537 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
FBXO5F-box protein 5. (447 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
SLC4A2Anion exchange protein. (1239 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
OMDOMD isoform 1. (421 aa)
ASPNAsporin. (378 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
BCORBCL6 corepressor. (1755 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
RXRARetinoid X receptor, alpha. (462 aa)
CK820_G0054574ISG15 isoform 1. (159 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TWIST1TWIST1 isoform 2. (163 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
ENPP1ENPP1 isoform 1. (925 aa)
RFLNARFLNA isoform 1. (216 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
BMP2KBMP2 inducible kinase. (1162 aa)
TXLNGYPutative gamma-taxilin 2; Belongs to the taxilin family. (143 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
AMELXAmelogenin X-linked. (205 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ENSPTRP00000060558annotation not available (149 aa)
ODAPHOdontogenesis associated phosphoprotein. (176 aa)
ISG15ISG15 ubiquitin-like modifier. (165 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ENSPTRP00000062265annotation not available (82 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ENSPTRP00000064416annotation not available (502 aa)
ANO6Anoctamin. (931 aa)
TENT5ATerminal nucleotidyltransferase 5A. (452 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
ALOX5ALOX5 isoform 2. (785 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
NBR1NBR1 isoform 1. (985 aa)
LOC100611078Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
TMEM119Transmembrane protein 119. (283 aa)
GPM6BGlycoprotein M6B. (305 aa)
ENSPTRP00000075468annotation not available (220 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
BCOR-2BCL6 corepressor. (1755 aa)
LOC745935C-C motif chemokine. (87 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
PTNPTN isoform 2. (172 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000082515annotation not available (336 aa)
ENAMENAM isoform 1. (1142 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (492 aa)
ENSPTRP00000086525annotation not available (336 aa)
GATA1GATA binding protein 1. (413 aa)
ENSPTRP00000087425annotation not available (336 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
FBN2FBN2 isoform 1. (2912 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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