STRINGSTRING
ADA ADA BAX BAX BCL2 BCL2 FAS FAS WNT5A WNT5A BBC3-2 BBC3-2 AKT1 AKT1 ENSPTRP00000081143 ENSPTRP00000081143 PDCD1 PDCD1 ENSPTRP00000079023 ENSPTRP00000079023 ENSPTRP00000078515 ENSPTRP00000078515 BCL2L11 BCL2L11 BBC3 BBC3 ENSPTRP00000074403 ENSPTRP00000074403 CHEK2 CHEK2 DNAJA3 DNAJA3 ENSPTRP00000062821 ENSPTRP00000062821 RPS6 RPS6 CK820_G0015936 CK820_G0015936 BCL11B BCL11B BAK1 BAK1 BCL3 BCL3 GLI3 GLI3 RIPK1 RIPK1 TP53 TP53 SIVA1 SIVA1 LMBR1L LMBR1L GPAM GPAM IL2RA IL2RA FASLG FASLG KIFAP3 KIFAP3 BCL10 BCL10 DFFA DFFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAAdenosine deaminase. (412 aa)
BAXBAX isoform 7. (123 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
FASFas (TNF receptor superfamily, member 6). (337 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BBC3-2BCL2 binding component 3. (270 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ENSPTRP00000081143annotation not available (219 aa)
PDCD1Programmed cell death 1. (288 aa)
ENSPTRP00000079023annotation not available (237 aa)
ENSPTRP00000078515annotation not available (198 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
BBC3BCL2 binding component 3. (270 aa)
ENSPTRP00000074403annotation not available (115 aa)
CHEK2Checkpoint kinase 2. (586 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
ENSPTRP00000062821annotation not available (220 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
BCL3BCL3 transcription coactivator. (454 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
KIFAP3Kinesin-associated protein 3. (792 aa)
BCL10B-cell CLL/lymphoma 10. (316 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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