12 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHEK2	Checkpoint kinase 2. (586 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	ENSPTRP00000078515	annotation not available (198 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	BAX	BAX isoform 7. (123 aa)
	DFFA	DNA fragmentation factor subunit alpha. (331 aa)
	KIFAP3	Kinesin-associated protein 3. (792 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	BAK1	BCL2-antagonist/killer 1. (211 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	ADA	Adenosine deaminase. (412 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BAX	ENSPTRP00000050271	ENSPTRP00000092787	BCL2-antagonist/killer 1.	BAX isoform 7.	0.957
BAK1	BCL2L11	ENSPTRP00000050271	ENSPTRP00000076253	BCL2-antagonist/killer 1.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.955
BAK1	TP53	ENSPTRP00000050271	ENSPTRP00000014836	BCL2-antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.988
BAX	BAK1	ENSPTRP00000092787	ENSPTRP00000050271	BAX isoform 7.	BCL2-antagonist/killer 1.	0.957
BAX	BCL2L11	ENSPTRP00000092787	ENSPTRP00000076253	BAX isoform 7.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.986
BAX	ENSPTRP00000078515	ENSPTRP00000092787	ENSPTRP00000078515	BAX isoform 7.	annotation not available	0.588
BAX	TP53	ENSPTRP00000092787	ENSPTRP00000014836	BAX isoform 7.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.940
BCL2L11	BAK1	ENSPTRP00000076253	ENSPTRP00000050271	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BCL2-antagonist/killer 1.	0.955
BCL2L11	BAX	ENSPTRP00000076253	ENSPTRP00000092787	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BAX isoform 7.	0.986
BCL2L11	ENSPTRP00000078515	ENSPTRP00000076253	ENSPTRP00000078515	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	annotation not available	0.916
BCL2L11	TP53	ENSPTRP00000076253	ENSPTRP00000014836	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.686
CHEK2	TP53	ENSPTRP00000067666	ENSPTRP00000014836	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
ENSPTRP00000078515	BAX	ENSPTRP00000078515	ENSPTRP00000092787	annotation not available	BAX isoform 7.	0.588
ENSPTRP00000078515	BCL2L11	ENSPTRP00000078515	ENSPTRP00000076253	annotation not available	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.916
ENSPTRP00000078515	TP53	ENSPTRP00000078515	ENSPTRP00000014836	annotation not available	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.870
TP53	BAK1	ENSPTRP00000014836	ENSPTRP00000050271	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BCL2-antagonist/killer 1.	0.988
TP53	BAX	ENSPTRP00000014836	ENSPTRP00000092787	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BAX isoform 7.	0.940
TP53	BCL2L11	ENSPTRP00000014836	ENSPTRP00000076253	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.686
TP53	CHEK2	ENSPTRP00000014836	ENSPTRP00000067666	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 2.	0.998
TP53	ENSPTRP00000078515	ENSPTRP00000014836	ENSPTRP00000078515	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	annotation not available	0.870