STRINGSTRING
FGF20 FGF20 PLA2G5 PLA2G5 DDR2 DDR2 PTPRC PTPRC CHI3L1 CHI3L1 DSTYK DSTYK SLC30A10 SLC30A10 NRP1 NRP1 NODAL NODAL FFAR4 FFAR4 FGFR2 FGFR2 HRAS HRAS FGF19 FGF19 FGF4 FGF4 P2RY6 P2RY6 OR2AT4 OR2AT4 FGF23 FGF23 IAPP IAPP IL26 IL26 TNFSF11 TNFSF11 HTR2A HTR2A SPRY2 SPRY2 GPR183 GPR183 BMP4 BMP4 CHRNA7 CHRNA7 TNFAIP8L3 TNFAIP8L3 NPTN NPTN SEMA7A SEMA7A PDE8A PDE8A CIB1 CIB1 PYCARD PYCARD NOD2 NOD2 MT3 MT3 CX3CL1 CX3CL1 NDRG4 NDRG4 NECAB2 NECAB2 ALOX15 ALOX15 ARRB2 ARRB2 SCIMP SCIMP CCL8 CCL8 CCL1 CCL1 CCL16 CCL16 CCL15 CCL15 CCL23 CCL23 PHB PHB PRKCA PRKCA ADCYAP1 ADCYAP1 CCL25 CCL25 TGFB1 TGFB1 CXCL17 CXCL17 PRKD2 PRKD2 FGF21 FGF21 ALKAL2 ALKAL2 DNAJC27 DNAJC27 FSHR FSHR IL1A IL1A HTR2B HTR2B ACKR3 ACKR3 BMP2 BMP2 SSTR4 SSTR4 PDGFB PDGFB GNAI2 GNAI2 P2RY1 P2RY1 KDR KDR FBXW7 FBXW7 FGB FGB FGA FGA NPY5R NPY5R F2R F2R F2RL1 F2RL1 FGF1 FGF1 HAVCR2 HAVCR2 FGFR4 FGFR4 TREM2 TREM2 TPBG TPBG NOD1 NOD1 BMPER BMPER RAMP3 RAMP3 CCL26 CCL26 CCL24 CCL24 MFHAS1 MFHAS1 PTK2B PTK2B CCL19 CCL19 CCL21 CCL21 NOTCH1 NOTCH1 ALKAL1 ALKAL1 S100A7L2 S100A7L2 ARRB1 ARRB1 CASR CASR OPRM1 OPRM1 CCL20 CCL20 FLT4 FLT4 CRKL CRKL NOX4 NOX4 CD74 CD74 VEGFB VEGFB NPSR1 NPSR1 GCG GCG PRXL2C PRXL2C AGER AGER HAND2 HAND2 SHC1 SHC1 GAREM2 GAREM2 CCL7 CCL7 CCR7 CCR7 MAPK3 MAPK3 C5AR1 C5AR1 APOE APOE CCL18 CCL18 CD4 CD4 CCL3 CCL3 CCL4 CCL4 GPBAR1 GPBAR1 MTURN MTURN CCL14 CCL14 C5AR2 C5AR2 PTPN11 PTPN11 CK820_G0012168 CK820_G0012168 APELA APELA ENSPTRP00000062123 ENSPTRP00000062123 THPO THPO ENSPTRP00000062913 ENSPTRP00000062913 ABCA7 ABCA7 MAP2K1 MAP2K1 ERBB4 ERBB4 FBXW9 FBXW9 NELFE NELFE TIRAP TIRAP CCL13 CCL13 ENSPTRP00000065453 ENSPTRP00000065453 GAREM1 GAREM1 DDTL DDTL ENSPTRP00000067174 ENSPTRP00000067174 DENND2B DENND2B FGF2 FGF2 IGF1 IGF1 ITGB3 ITGB3 S100A7A S100A7A CCL2 CCL2 SLAMF1 SLAMF1 ENSPTRP00000069037 ENSPTRP00000069037 RIPK2 RIPK2 EGFR EGFR TEK TEK ARHGAP8 ARHGAP8 CCL24-2 CCL24-2 RASGRP1 RASGRP1 ABL1 ABL1 NRXN1 NRXN1 PTPN11-2 PTPN11-2 CALCR CALCR MAP3K12 MAP3K12 ENSPTRP00000073763 ENSPTRP00000073763 MAP2K7 MAP2K7 CD36 CD36 ENSPTRP00000074763 ENSPTRP00000074763 CAVIN3 CAVIN3 PTPN22 PTPN22 FGF8 FGF8 NOTCH2 NOTCH2 GATA4 GATA4 S100A7 S100A7 ENSPTRP00000076429 ENSPTRP00000076429 SRC SRC ENSPTRP00000077211 ENSPTRP00000077211 DDT DDT CCR1 CCR1 CCL22 CCL22 PDGFD PDGFD CFLAR CFLAR CK820_G0040570 CK820_G0040570 LOC745935 LOC745935 RAPGEF2 RAPGEF2 BRAF BRAF ENSPTRP00000079495 ENSPTRP00000079495 PDGFRB PDGFRB BMP4-2 BMP4-2 FERMT2 FERMT2 CSF1R CSF1R HCRTR1 HCRTR1 AKAP12 AKAP12 CCL5 CCL5 NTRK1 NTRK1 FGF10 FGF10 FGG FGG CCL17 CCL17 ICAM1 ICAM1 ADRA1A ADRA1A RAP1A RAP1A LOC112204135 LOC112204135 GCNT2 GCNT2 TRPV4 TRPV4 NPNT NPNT LOC747294 LOC747294 GPNMB GPNMB ENSPTRP00000087328 ENSPTRP00000087328 LOC455004 LOC455004 LGALS9 LGALS9 PLA2G2A PLA2G2A CK820_G0040570-2 CK820_G0040570-2 FGFR3 FGFR3 BRAF-2 BRAF-2 TNFRSF11A TNFRSF11A ENSPTRP00000089450 ENSPTRP00000089450 ENSPTRP00000089473 ENSPTRP00000089473 LOC469572 LOC469572 CCN2 CCN2 ENSPTRP00000090382 ENSPTRP00000090382 PDGFC PDGFC MIF MIF CD44 CD44 PTEN PTEN SERPINF2 SERPINF2 ENSPTRP00000091224 ENSPTRP00000091224 PHB2 PHB2 FGF18 FGF18 ANGPT1 ANGPT1 NRG1 NRG1 ENSPTRP00000092364 ENSPTRP00000092364 GLIPR2 GLIPR2 ENSPTRP00000093022 ENSPTRP00000093022 CCL11 CCL11 CARD9 CARD9 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PLA2G5Phospholipase A(2). (138 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
CHI3L1Chitinase 3-like 1 (Cartilage glycoprotein-39); Belongs to the glycosyl hydrolase 18 family. (383 aa)
DSTYKDual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. (930 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NODALNODAL isoform 2. (347 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
OR2AT4Olfactory receptor. (320 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
IAPPIslet amyloid polypeptide. (89 aa)
IL26IL26 isoform 1. (171 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
SPRY2Sprouty homolog 2. (338 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CHRNA7CHRNA7 isoform 7. (511 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (292 aa)
NPTNNPTN isoform 2. (398 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
PDE8APhosphodiesterase. (829 aa)
CIB1Calcium and integrin binding 1. (231 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
NDRG4NDRG family member 4. (226 aa)
NECAB2N-terminal EF-hand calcium binding protein 2. (386 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
ARRB2ARRB2 isoform 2. (430 aa)
SCIMPSCIMP isoform 1. (144 aa)
CCL8C-C motif chemokine. (109 aa)
CCL1C-C motif chemokine. (96 aa)
CCL16C-C motif chemokine. (120 aa)
CCL15C-C motif chemokine. (113 aa)
CCL23C-C motif chemokine. (137 aa)
PHBProhibitin. (272 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ALKAL2Family with sequence similarity 150, member B. (152 aa)
DNAJC27DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
ACKR3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
SSTR4Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (388 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (866 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
F2RCoagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TPBGTrophoblast glycoprotein. (420 aa)
NOD1Nucleotide-binding oligomerization domain containing 1. (953 aa)
BMPERBMP binding endothelial regulator. (685 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
CCL26C-C motif chemokine. (94 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CCL19C-C motif chemokine. (98 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
S100A7L2S100 calcium binding protein A7 like 2. (112 aa)
ARRB1ARRB1 isoform 1. (418 aa)
CASRCalcium sensing receptor. (1078 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
CCL20C-C motif chemokine. (96 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
NOX4NADPH oxidase 4. (578 aa)
CD74CD74 isoform 5. (296 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
GCGGCG isoform 1. (180 aa)
PRXL2CAAED1 isoform 2. (226 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (874 aa)
CCL7C-C motif chemokine. (109 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
CCL18C-C motif chemokine. (89 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
CCL4C-C motif chemokine. (92 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
CCL14C-C motif chemokine. (109 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ENSPTRP00000062123annotation not available (256 aa)
THPOTHPO isoform 1. (353 aa)
ENSPTRP00000062913annotation not available (169 aa)
ABCA7ABCA7 isoform 3. (1829 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
NELFENegative elongation factor complex member E. (389 aa)
TIRAPToll-interleukin 1 receptor (TIR) domain containing adaptor protein. (235 aa)
CCL13C-C motif chemokine. (98 aa)
ENSPTRP00000065453annotation not available (288 aa)
GAREM1Family with sequence similarity 59, member A. (875 aa)
DDTLDDT isoform 5. (134 aa)
ENSPTRP00000067174annotation not available (502 aa)
DENND2BSuppression of tumorigenicity 5. (1137 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
CCL2C-C motif chemokine. (109 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
ENSPTRP00000069037annotation not available (328 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ARHGAP8PRR5-ARHGAP8 isoform 3. (464 aa)
CCL24-2C-C motif chemokine ligand 24. (119 aa)
RASGRP1RASGRP1 isoform 4. (848 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
ENSPTRP00000073763annotation not available (92 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (438 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
ENSPTRP00000074763annotation not available (520 aa)
CAVIN3Caveolae associated protein 3. (293 aa)
PTPN22Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid). (807 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GATA4GATA binding protein 4. (443 aa)
S100A7Protein S100; Belongs to the S-100 family. (101 aa)
ENSPTRP00000076429annotation not available (110 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000077211annotation not available (269 aa)
DDTDDT isoform 2. (166 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCL22C-C motif chemokine. (93 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
CK820_G0040570PRKCZ isoform 2. (457 aa)
LOC745935C-C motif chemokine. (87 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
ENSPTRP00000079495annotation not available (194 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FERMT2Fermitin family member 2. (706 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
AKAP12AKAP12 isoform 1. (1780 aa)
CCL5C-C motif chemokine. (91 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGGFibrinogen gamma chain. (453 aa)
CCL17C-C motif chemokine. (94 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
LOC112204135X-C motif chemokine ligand 1. (114 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group). (402 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
NPNTNPNT isoform 10. (611 aa)
LOC747294D-dopachrome decarboxylase. (147 aa)
GPNMBGPNMB isoform 2. (574 aa)
ENSPTRP00000087328annotation not available (242 aa)
LOC455004CCL4L2 isoform 3. (103 aa)
LGALS9Galectin. (355 aa)
PLA2G2APhospholipase A(2). (144 aa)
CK820_G0040570-2PRKCZ isoform 4. (95 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
BRAF-2BRAF isoform 2. (766 aa)
TNFRSF11ATNF receptor superfamily member 11a. (617 aa)
ENSPTRP00000089450annotation not available (303 aa)
ENSPTRP00000089473annotation not available (177 aa)
LOC469572Lymphotactin. (114 aa)
CCN2CTGF isoform 1. (349 aa)
ENSPTRP00000090382annotation not available (493 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
CD44CD44 isoform 3. (742 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
ENSPTRP00000091224annotation not available (312 aa)
PHB2Prohibitin. (299 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
NRG1NRG1 isoform 3. (713 aa)
ENSPTRP00000092364annotation not available (574 aa)
GLIPR2GLIPR2 isoform 2; Belongs to the CRISP family. (165 aa)
ENSPTRP00000093022annotation not available (563 aa)
CCL11C-C motif chemokine. (97 aa)
CARD9Caspase recruitment domain family, member 9. (536 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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