15 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	SMAD7	Mothers against decapentaplegic homolog. (491 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMAD1	Mothers against decapentaplegic homolog. (469 aa)
	AXIN1	AXIN1 isoform 2. (859 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	SMAD9	Mothers against decapentaplegic homolog. (467 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)
	INTS8	Integrator complex subunit 8. (995 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	AXIN2	ENSPTRP00000042391	ENSPTRP00000016228	AXIN1 isoform 2.	AXIN2 isoform 1.	0.951
AXIN1	CTNNB1	ENSPTRP00000042391	ENSPTRP00000044466	AXIN1 isoform 2.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.999
AXIN1	SMAD2	ENSPTRP00000042391	ENSPTRP00000062376	AXIN1 isoform 2.	Mothers against decapentaplegic homolog.	0.488
AXIN1	SMAD3	ENSPTRP00000042391	ENSPTRP00000090625	AXIN1 isoform 2.	Mothers against decapentaplegic homolog.	0.595
AXIN1	SMAD4	ENSPTRP00000042391	ENSPTRP00000017047	AXIN1 isoform 2.	Mothers against decapentaplegic homolog.	0.422
AXIN1	SMAD7	ENSPTRP00000042391	ENSPTRP00000017016	AXIN1 isoform 2.	Mothers against decapentaplegic homolog.	0.747
AXIN1	SMURF1	ENSPTRP00000042391	ENSPTRP00000047812	AXIN1 isoform 2.	E3 ubiquitin-protein ligase.	0.677
AXIN2	AXIN1	ENSPTRP00000016228	ENSPTRP00000042391	AXIN2 isoform 1.	AXIN1 isoform 2.	0.951
AXIN2	CTNNB1	ENSPTRP00000016228	ENSPTRP00000044466	AXIN2 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.997
AXIN2	SMAD7	ENSPTRP00000016228	ENSPTRP00000017016	AXIN2 isoform 1.	Mothers against decapentaplegic homolog.	0.443
AXIN2	SMURF1	ENSPTRP00000016228	ENSPTRP00000047812	AXIN2 isoform 1.	E3 ubiquitin-protein ligase.	0.577
CTNNB1	AXIN1	ENSPTRP00000044466	ENSPTRP00000042391	Catenin (Cadherin-associated protein), beta 1, 88kDa.	AXIN1 isoform 2.	0.999
CTNNB1	AXIN2	ENSPTRP00000044466	ENSPTRP00000016228	Catenin (Cadherin-associated protein), beta 1, 88kDa.	AXIN2 isoform 1.	0.997
CTNNB1	SMAD1	ENSPTRP00000044466	ENSPTRP00000028297	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.504
CTNNB1	SMAD2	ENSPTRP00000044466	ENSPTRP00000062376	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.938
CTNNB1	SMAD3	ENSPTRP00000044466	ENSPTRP00000090625	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.991
CTNNB1	SMAD4	ENSPTRP00000044466	ENSPTRP00000017047	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.898
CTNNB1	SMAD5	ENSPTRP00000044466	ENSPTRP00000080233	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.657
CTNNB1	SMAD6	ENSPTRP00000044466	ENSPTRP00000012318	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.405
CTNNB1	SMAD7	ENSPTRP00000044466	ENSPTRP00000017016	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mothers against decapentaplegic homolog.	0.778