STRINGSTRING
SDCBP SDCBP GATA3 GATA3 IL6ST IL6ST FGF22 FGF22 FGF2 FGF2 PSPN PSPN IL6 IL6 ITGB3 ITGB3 EFEMP1 EFEMP1 ENSPTRP00000068859 ENSPTRP00000068859 FLRT2 FLRT2 IL4-2 IL4-2 CK820_G0030851 CK820_G0030851 LOC739666 LOC739666 NRXN1 NRXN1 ENSPTRP00000073371 ENSPTRP00000073371 TSLP TSLP CADM4 CADM4 CK820_G0050194 CK820_G0050194 IL1R1 IL1R1 IL36RN IL36RN FGF8 FGF8 TLR5 TLR5 SRC SRC ENSPTRP00000077070 ENSPTRP00000077070 FYN FYN PDGFD PDGFD TGFA TGFA IL7 IL7 IL1RN IL1RN PDGFRB PDGFRB ERN1 ERN1 IL6-2 IL6-2 FRS3-2 FRS3-2 LOC470874 LOC470874 ENSPTRP00000081592 ENSPTRP00000081592 JAK2 JAK2 IL5 IL5 PDCL3 PDCL3 ENSPTRP00000082827 ENSPTRP00000082827 IL1RAP IL1RAP FGF10 FGF10 TOLLIP TOLLIP ERAP1 ERAP1 VAV2 VAV2 LOC735923 LOC735923 CD2AP CD2AP CBLC CBLC FGF6 FGF6 ARTN ARTN NCSTN NCSTN SNX1 SNX1 FAM83B FAM83B FGF18 FGF18 PDGFC PDGFC TNK2 TNK2 FRS2 FRS2 VAV3 VAV3 ENSPTRP00000089475 ENSPTRP00000089475 TNK2-2 TNK2-2 ENSPTRP00000086563 ENSPTRP00000086563 FGF20 FGF20 GLMN GLMN ECM1 ECM1 PTPRJ PTPRJ CNTF CNTF MS4A15 MS4A15 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 FGF23 FGF23 IRAK4 IRAK4 ITGA5 ITGA5 RNF41 RNF41 FGF9 FGF9 KL KL PIBF1 PIBF1 PSEN1 PSEN1 FGF7 FGF7 NPTN NPTN PYCARD PYCARD CDH5 CDH5 CD300LF CD300LF SLC9A3R1 SLC9A3R1 GRB2 GRB2 RNF126 RNF126 NRTN NRTN TIMM50 TIMM50 FGF21 FGF21 IL11 IL11 CCDC88A CCDC88A IL1A IL1A IL1B IL1B IL36G IL36G IL36A IL36A IL1F10 IL1F10 FLRT3 FLRT3 PDGFB PDGFB ARF4 ARF4 SNX4 SNX4 IL12A IL12A KLB KLB PDCL2 PDCL2 EPGN EPGN EREG EREG BTC BTC FGF5 FGF5 EGF EGF IL2 IL2 IL21 IL21 VEGFC VEGFC ESM1 ESM1 FER FER IL3 IL3 CSF2 CSF2 ENSPTRP00000029460 ENSPTRP00000029460 IL4 IL4 IL9 IL9 CYSTM1 CYSTM1 HBEGF HBEGF FGF1 FGF1 IL12B IL12B FRS3 FRS3 AGR2 AGR2 HIP1 HIP1 TRIP6 TRIP6 LINGO2 LINGO2 VEGFD VEGFD CSF3 CSF3 FGF17 FGF17 FGF16 FGF16 LYN LYN VEGFB VEGFB LOC451223 LOC451223 SNX2 SNX2 GDNF GDNF PLSCR1 PLSCR1 LINGO1 LINGO1 SHC1 SHC1 ADAM17 ADAM17 DAB2IP DAB2IP ATXN2 ATXN2 PGF PGF SOCS5 SOCS5 AREG AREG MYD88 MYD88 ENSPTRP00000062093 ENSPTRP00000062093 CNOT9 CNOT9 ERBB4 ERBB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SDCBPSyndecan binding protein. (324 aa)
GATA3GATA binding protein 3. (444 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
PSPNPSPN isoform 2. (156 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (493 aa)
ENSPTRP00000068859annotation not available (227 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
IL4-2Interleukin 4. (153 aa)
CK820_G0030851MS4A4E isoform 1. (154 aa)
LOC739666Syntenin-1-like. (289 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
ENSPTRP00000073371annotation not available (431 aa)
TSLPTSLP isoform 1. (159 aa)
CADM4Cell adhesion molecule 4. (388 aa)
CK820_G0050194GRAP isoform 1. (153 aa)
IL1R1Interleukin 1 receptor, type I. (569 aa)
IL36RNInterleukin-1. (155 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000077070annotation not available (669 aa)
FYNTyrosine-protein kinase. (537 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
TGFATGFA isoform 6. (193 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
IL1RNInterleukin-1. (180 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
IL6-2Interleukin 6. (234 aa)
FRS3-2Fibroblast growth factor receptor substrate 3. (492 aa)
LOC470874Phosducin-like protein 3 pseudogene. (191 aa)
ENSPTRP00000081592annotation not available (837 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PDCL3Phosducin-like 3. (239 aa)
ENSPTRP00000082827annotation not available (151 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TOLLIPToll interacting protein. (275 aa)
ERAP1Aminopeptidase. (952 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
LOC735923Phosducin-like protein 3 pseudogene. (220 aa)
CD2APCD2-associated protein. (650 aa)
CBLCCbl proto-oncogene C. (474 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARTNARTN isoform 11. (235 aa)
NCSTNNCSTN isoform 1. (721 aa)
SNX1Sorting nexin 1. (557 aa)
FAM83BFamily with sequence similarity 83 member B. (1011 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
TNK2TNK2 isoform 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
VAV3VAV3 isoform 2. (927 aa)
ENSPTRP00000089475annotation not available (268 aa)
TNK2-2Tyrosine kinase non receptor 2. (86 aa)
ENSPTRP00000086563annotation not available (245 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
ECM1Extracellular matrix protein 1. (540 aa)
PTPRJPTPRJ isoform 4. (1312 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MS4A15MS4A15 isoform 4. (240 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
RNF41Ring finger protein 41. (317 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KLKL isoform 1. (1012 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NPTNNPTN isoform 2. (398 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
CD300LFCD300 molecule like family member f. (305 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RNF126Ring finger protein 126. (311 aa)
NRTNNRTN isoform 1. (197 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (456 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
IL11IL11 isoform 1. (199 aa)
CCDC88ACoiled-coil domain containing 88A. (1870 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL36GInterleukin-1. (169 aa)
IL36AInterleukin-1. (158 aa)
IL1F10Interleukin-1. (152 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ARF4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
SNX4Sorting nexin 4. (450 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
KLBKLB isoform 1. (1044 aa)
PDCL2Phosducin like 2. (241 aa)
EPGNEpithelial mitogen. (154 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
ESM1Endothelial cell-specific molecule 1. (184 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (152 aa)
CSF2Colony stimulating factor 2. (144 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
IL9IL9 isoform 1. (144 aa)
CYSTM1Cysteine rich transmembrane module containing 1. (97 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
HIP1HIP1 isoform 2. (1037 aa)
TRIP6Thyroid receptor-interacting protein 6. (476 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LYNTyrosine-protein kinase. (512 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
LOC451223MS4A1 isoform 1. (297 aa)
SNX2Sorting nexin 2. (519 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
ADAM17ADAM17 isoform 3. (999 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
ATXN2ATXN2 isoform 2. (1154 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
AREGAREG isoform 2. (274 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
ENSPTRP00000062093annotation not available (1025 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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