12 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
	RYR1	RYR1 isoform 3. (5037 aa)
	RYR3	Ryanodine receptor 3. (4873 aa)
	CK820_G0030361	RYR1 isoform 5. (4901 aa)
	TMEM38B	Transmembrane protein 38B. (297 aa)
	SELENON	T0161445 isoform 2. (581 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	CHEK1	CHEK1 isoform 10. (485 aa)
	RYR2	RYR2 isoform 1. (4941 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	ENSPTRP00000061732	annotation not available (285 aa)
	TMEM38A	Transmembrane protein 38A. (299 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1S	CK820_G0030361	ENSPTRP00000074991	ENSPTRP00000090805	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	RYR1 isoform 5.	0.759
CACNA1S	RYR1	ENSPTRP00000074991	ENSPTRP00000092559	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	RYR1 isoform 3.	0.841
CACNA1S	RYR2	ENSPTRP00000074991	ENSPTRP00000064508	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	RYR2 isoform 1.	0.626
CACNA1S	RYR3	ENSPTRP00000074991	ENSPTRP00000090974	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Ryanodine receptor 3.	0.464
CASQ2	RYR1	ENSPTRP00000001966	ENSPTRP00000092559	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	RYR1 isoform 3.	0.959
CASQ2	RYR2	ENSPTRP00000001966	ENSPTRP00000064508	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	RYR2 isoform 1.	0.991
CASQ2	RYR3	ENSPTRP00000001966	ENSPTRP00000090974	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 3.	0.962
CASQ2	SLC8A1	ENSPTRP00000001966	ENSPTRP00000064174	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.428
CK820_G0030361	CACNA1S	ENSPTRP00000090805	ENSPTRP00000074991	RYR1 isoform 5.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.759
CK820_G0030361	RYR2	ENSPTRP00000090805	ENSPTRP00000064508	RYR1 isoform 5.	RYR2 isoform 1.	0.702
CK820_G0030361	RYR3	ENSPTRP00000090805	ENSPTRP00000090974	RYR1 isoform 5.	Ryanodine receptor 3.	0.621
CK820_G0030361	SELENON	ENSPTRP00000090805	ENSPTRP00000086380	RYR1 isoform 5.	T0161445 isoform 2.	0.589
RYR1	CACNA1S	ENSPTRP00000092559	ENSPTRP00000074991	RYR1 isoform 3.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.841
RYR1	CASQ2	ENSPTRP00000092559	ENSPTRP00000001966	RYR1 isoform 3.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.959
RYR1	RYR2	ENSPTRP00000092559	ENSPTRP00000064508	RYR1 isoform 3.	RYR2 isoform 1.	0.969
RYR1	RYR3	ENSPTRP00000092559	ENSPTRP00000090974	RYR1 isoform 3.	Ryanodine receptor 3.	0.960
RYR1	SELENON	ENSPTRP00000092559	ENSPTRP00000086380	RYR1 isoform 3.	T0161445 isoform 2.	0.589
RYR2	CACNA1S	ENSPTRP00000064508	ENSPTRP00000074991	RYR2 isoform 1.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.626
RYR2	CASQ2	ENSPTRP00000064508	ENSPTRP00000001966	RYR2 isoform 1.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.991
RYR2	CK820_G0030361	ENSPTRP00000064508	ENSPTRP00000090805	RYR2 isoform 1.	RYR1 isoform 5.	0.702