18 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	AKAP8	A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family. (692 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	TNFSF4	Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	PTGER2	Prostaglandin E receptor 2 (Subtype EP2), 53kDa; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	PTGER4	Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
	FN1	FN1 isoform 1. (2477 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	GNAS	GNAS isoform 19. (1042 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
	GNB1	Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
	AKT1	AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	PPARG	ENSPTRP00000074254	ENSPTRP00000076701	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma isoform X2.	0.547
ACACA	PRKAA1	ENSPTRP00000074254	ENSPTRP00000048213	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.959
ACACA	PRKAA2	ENSPTRP00000074254	ENSPTRP00000001359	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.937
ADCY6	AKT1	ENSPTRP00000093557	ENSPTRP00000082849	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.707
ADCY6	GNAS	ENSPTRP00000093557	ENSPTRP00000059419	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS isoform 19.	0.974
ADCY6	GNB1	ENSPTRP00000093557	ENSPTRP00000067330	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.770
ADCY6	GNG2	ENSPTRP00000093557	ENSPTRP00000065345	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.784
AKT1	ADCY6	ENSPTRP00000082849	ENSPTRP00000093557	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.707
AKT1	GNB1	ENSPTRP00000082849	ENSPTRP00000067330	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.423
AKT1	PPARG	ENSPTRP00000082849	ENSPTRP00000076701	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Peroxisome proliferator-activated receptor gamma isoform X2.	0.626
AKT1	PRKAA1	ENSPTRP00000082849	ENSPTRP00000048213	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.497
AKT1	PRKAA2	ENSPTRP00000082849	ENSPTRP00000001359	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.471
GNAS	ADCY6	ENSPTRP00000059419	ENSPTRP00000093557	GNAS isoform 19.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.974
GNAS	GNB1	ENSPTRP00000059419	ENSPTRP00000067330	GNAS isoform 19.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.998
GNAS	GNG2	ENSPTRP00000059419	ENSPTRP00000065345	GNAS isoform 19.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.987
GNAS	PTGER2	ENSPTRP00000059419	ENSPTRP00000010757	GNAS isoform 19.	Prostaglandin E receptor 2 (Subtype EP2), 53kDa; Belongs to the G-protein coupled receptor 1 family.	0.986
GNAS	PTGER4	ENSPTRP00000059419	ENSPTRP00000028838	GNAS isoform 19.	Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.986
GNB1	ADCY6	ENSPTRP00000067330	ENSPTRP00000093557	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.770
GNB1	AKT1	ENSPTRP00000067330	ENSPTRP00000082849	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.423
GNB1	GNAS	ENSPTRP00000067330	ENSPTRP00000059419	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	GNAS isoform 19.	0.998