39 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EN1	Homeobox protein engrailed-like. (396 aa)
	PHOX2A	Paired like homeobox 2A. (284 aa)
	PITX3	Homeobox protein. (302 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	OTX2	Orthodenticle homeobox 2. (297 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	MANF	MANF isoform 1. (246 aa)
	RYK	Receptor like tyrosine kinase. (610 aa)
	PHOX2B	Paired like homeobox 2B. (314 aa)
	OTP	Orthopedia homeobox. (325 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	LMX1B	LIM homeobox transcription factor 1 beta. (402 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	FOXA2	FOXA2 isoform 1. (464 aa)
	NR4A2	Nuclear receptor subfamily 4, group A, member 2. (598 aa)
	FZD1	FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	HPRT1	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	WNT3-2	Wnt family member 3. (290 aa)
	WNT9B-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	EN2-2	Homeobox protein engrailed-like. (336 aa)
	EN2	Engrailed homeobox 2. (338 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	RSPO2	R-spondin 2 homolog. (243 aa)
	FOXA1	FOXA1 isoform 1. (471 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	FZD1-2	Frizzled class receptor 1. (580 aa)
	DMRTA2	DMRT like family A2. (539 aa)
	LMX1A	LIM homeobox transcription factor 1 alpha. (382 aa)
	CDNF	Cerebral dopamine neurotrophic factor. (187 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	FGF8	ENSPTRP00000044466	ENSPTRP00000075677	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.633
CTNNB1	FOXA1	ENSPTRP00000044466	ENSPTRP00000062658	Catenin (Cadherin-associated protein), beta 1, 88kDa.	FOXA1 isoform 1.	0.504
CTNNB1	FZD1	ENSPTRP00000044466	ENSPTRP00000087775	Catenin (Cadherin-associated protein), beta 1, 88kDa.	FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.676
CTNNB1	FZD1-2	ENSPTRP00000044466	ENSPTRP00000093055	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Frizzled class receptor 1.	0.676
CTNNB1	HIF1A	ENSPTRP00000044466	ENSPTRP00000010887	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Hypoxia inducible factor 1 subunit alpha.	0.952
CTNNB1	LRP6	ENSPTRP00000044466	ENSPTRP00000008035	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.902
CTNNB1	MANF	ENSPTRP00000044466	ENSPTRP00000025845	Catenin (Cadherin-associated protein), beta 1, 88kDa.	MANF isoform 1.	0.491
CTNNB1	RSPO2	ENSPTRP00000044466	ENSPTRP00000063985	Catenin (Cadherin-associated protein), beta 1, 88kDa.	R-spondin 2 homolog.	0.482
CTNNB1	RYK	ENSPTRP00000044466	ENSPTRP00000026572	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Receptor like tyrosine kinase.	0.493
CTNNB1	SFRP1	ENSPTRP00000044466	ENSPTRP00000053182	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Secreted frizzled-related protein 1.	0.727
CTNNB1	SHH	ENSPTRP00000044466	ENSPTRP00000075730	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
CTNNB1	SMO	ENSPTRP00000044466	ENSPTRP00000033707	Catenin (Cadherin-associated protein), beta 1, 88kDa.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.479
CTNNB1	SMO-2	ENSPTRP00000044466	ENSPTRP00000067533	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Smoothened, frizzled class receptor.	0.479
CTNNB1	WNT1	ENSPTRP00000044466	ENSPTRP00000008364	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.846
CTNNB1	WNT2	ENSPTRP00000044466	ENSPTRP00000033593	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).	0.630
CTNNB1	WNT3	ENSPTRP00000044466	ENSPTRP00000015851	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.689
CTNNB1	WNT3-2	ENSPTRP00000044466	ENSPTRP00000078190	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Wnt family member 3.	0.689
CTNNB1	WNT3A	ENSPTRP00000044466	ENSPTRP00000051074	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.817
CTNNB1	WNT5A	ENSPTRP00000044466	ENSPTRP00000086163	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.746
CTNNB1	WNT9B	ENSPTRP00000044466	ENSPTRP00000059920	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.489