STRINGSTRING
EN1 EN1 PHOX2A PHOX2A PITX3 PITX3 LRP6 LRP6 WNT1 WNT1 OTX2 OTX2 HIF1A HIF1A WNT3 WNT3 MANF MANF RYK RYK PHOX2B PHOX2B OTP OTP WNT2 WNT2 SMO SMO LMX1B LMX1B VEGFD VEGFD CTNNB1 CTNNB1 TSHR TSHR FOXA2 FOXA2 NR4A2 NR4A2 FZD1 FZD1 HPRT1 HPRT1 WNT5A WNT5A WNT3-2 WNT3-2 WNT9B-2 WNT9B-2 SHH SHH FGF8 FGF8 EN2-2 EN2-2 EN2 EN2 SMO-2 SMO-2 RSPO2 RSPO2 FOXA1 FOXA1 WNT9B WNT9B SFRP1 SFRP1 WNT3A WNT3A FZD1-2 FZD1-2 DMRTA2 DMRTA2 LMX1A LMX1A CDNF CDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EN1Homeobox protein engrailed-like. (396 aa)
PHOX2APaired like homeobox 2A. (284 aa)
PITX3Homeobox protein. (302 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
MANFMANF isoform 1. (246 aa)
RYKReceptor like tyrosine kinase. (610 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
OTPOrthopedia homeobox. (325 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
FOXA2FOXA2 isoform 1. (464 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT3-2Wnt family member 3. (290 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EN2-2Homeobox protein engrailed-like. (336 aa)
EN2Engrailed homeobox 2. (338 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
RSPO2R-spondin 2 homolog. (243 aa)
FOXA1FOXA1 isoform 1. (471 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
DMRTA2DMRT like family A2. (539 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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