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EGR1 EGR1 GDF9-2 GDF9-2 HJV HJV CHRD CHRD WNT5A WNT5A TMEM100 TMEM100 SOSTDC1-2 SOSTDC1-2 HEYL HEYL SMAD3 SMAD3 RGMB RGMB PHOX2B PHOX2B ZNF831 ZNF831 BMP7 BMP7 GDF5 GDF5 BMP2 BMP2 ACVR2A ACVR2A CCDC142 CCDC142 GDF7 GDF7 ZNF8 ZNF8 MEGF8 MEGF8 TGFB1 TGFB1 FKBP8 FKBP8 GDF15 GDF15 SMAD4 SMAD4 SMAD7 SMAD7 GATA6 GATA6 SFRP1 SFRP1 BMPR2 BMPR2 SMURF1 SMURF1 SLC33A1 SLC33A1 DSG4 DSG4 FN1 FN1 COL2A1 COL2A1 SPART SPART HES5 HES5 DLX1 DLX1 USP9Y USP9Y ZCCHC12 ZCCHC12 BMP15 BMP15 ENG ENG CER1 CER1 EXT1 EXT1 DLX5 DLX5 BMPER BMPER BMP5 BMP5 BMP6 BMP6 GDF9 GDF9 FST FST SFRP2 SFRP2 SMAD1 SMAD1 BMPR1B BMPR1B MAPK3 MAPK3 MSX1 MSX1 COMP COMP SMAD9 SMAD9 ADAMTS12 ADAMTS12 CK820_G0012168 CK820_G0012168 TMPRSS6 TMPRSS6 SMAD2 SMAD2 RGMA RGMA VSTM2A VSTM2A ATF2 ATF2 HES1 HES1 ENSPTRP00000064416 ENSPTRP00000064416 GATA3 GATA3 RUNX2 RUNX2 TGFBR3 TGFBR3 SOSTDC1 SOSTDC1 USP9X USP9X ETV2 ETV2 GDF2 GDF2 ABL1 ABL1 SCX SCX USP15 USP15 GATA5 GATA5 ACVR1 ACVR1 NOTCH2 NOTCH2 GDF6 GDF6 HIVEP1 HIVEP1 PPARG PPARG ACVR2B ACVR2B BMP10 BMP10 ENSPTRP00000079019 ENSPTRP00000079019 HFE HFE LEFTY1 LEFTY1 LEF1 LEF1 ZCCHC18 ZCCHC18 SMAD5 SMAD5 PDCD4 PDCD4 HES5-2 HES5-2 TWSG1 TWSG1 SOX9 SOX9 DDX5 DDX5 NOG NOG DLX3 DLX3 SOST SOST FAM83G FAM83G SMPD3 SMPD3 ADAMTS7 ADAMTS7 SMAD6 SMAD6 SPINT1 SPINT1 TGFB3 TGFB3 BMP4 BMP4 SLC39A5 SLC39A5 ACVRL1 ACVRL1 GDF3 GDF3 BMPR1A BMPR1A NODAL NODAL LEFTY2 LEFTY2 TGFB2 TGFB2 BMP8B BMP8B ENSPTRP00000000998 ENSPTRP00000000998 CHRDL1 CHRDL1 BMP4-2 BMP4-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
GDF9-2Growth differentiation factor 9. (455 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TMEM100Transmembrane protein 100. (134 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (478 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
ZNF831Zinc finger protein 831. (1679 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
GDF7Growth differentiation factor 7. (447 aa)
ZNF8KRAB domain-containing zinc finger protein. (575 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
GDF15Growth differentiation factor 15. (308 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
GATA6GATA binding protein 6. (594 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SLC33A1Solute carrier family 33 (Acetyl-CoA transporter), member 1. (549 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
FN1FN1 isoform 1. (2477 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
DLX1Distal-less homeobox 1. (255 aa)
USP9YUSP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
BMP15BMP15 isoform 1. (369 aa)
ENGENG isoform 1. (658 aa)
CER1CER1 isoform 1. (267 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
DLX5Distal-less homeobox 5. (289 aa)
BMPERBMP binding endothelial regulator. (685 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
GDF9Growth differentiation factor 9. (455 aa)
FSTFST isoform 1. (344 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
VSTM2AV-set and transmembrane domain containing 2A. (309 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064416annotation not available (502 aa)
GATA3GATA binding protein 3. (444 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
ETV2ETV2 isoform 5. (370 aa)
GDF2GDF2 isoform 1. (429 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
GATA5GATA binding protein 5. (397 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GDF6Growth differentiation factor 6. (455 aa)
HIVEP1HIVEP1 isoform 1. (2718 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPTRP00000079019annotation not available (165 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
LEFTY1Left-right determination factor. (366 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ZCCHC18ZCCHC18 isoform 2. (377 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DLX3Distal-less homeobox 3. (287 aa)
SOSTSOST isoform 1. (213 aa)
FAM83GFamily with sequence similarity 83, member G. (823 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ADAMTS7ADAMTS7 isoform 1. (932 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SPINT1SPINT1 isoform 2. (529 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF3Growth differentiation factor 3. (364 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNODAL isoform 2. (347 aa)
LEFTY2Left-right determination factor. (366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8BBMP8B isoform 1. (402 aa)
ENSPTRP00000000998annotation not available (224 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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