STRINGSTRING
LAMA5 LAMA5 MEF2C MEF2C PAX2 PAX2 ANGPT1 ANGPT1 FOXD1 FOXD1 LGR4 LGR4 PROM1 PROM1 LAMB2 LAMB2 PDGFB PDGFB BMP7 BMP7 GZF1 GZF1 JAG1 JAG1 BMP2 BMP2 COL4A3 COL4A3 SIX2 SIX2 MPV17 MPV17 OSR1 OSR1 TMEM59L TMEM59L NOTCH3 NOTCH3 SMAD4 SMAD4 GREB1 GREB1 FOXJ1 FOXJ1 SOX9 SOX9 NOG NOG ITGA3 ITGA3 WNK4 WNK4 IRX3 IRX3 SOX8 SOX8 IQGAP1 IQGAP1 MYO1E MYO1E BMP4 BMP4 EDNRB EDNRB NUP107 NUP107 WNT1 WNT1 ACAT1 ACAT1 AQP11 AQP11 ERBB4 ERBB4 WNT11 WNT11 NID1 NID1 NUP133 NUP133 CD34 CD34 NPHS2 NPHS2 TACSTD2 TACSTD2 WNT4 WNT4 WNT7B WNT7B FMN1 FMN1 HES1 HES1 NUP85 NUP85 SALL1 SALL1 KLF15 KLF15 GATA3 GATA3 CK820_G0056924 CK820_G0056924 FOXC1 FOXC1 ILK ILK DLG1 DLG1 SMO-2 SMO-2 BASP1 BASP1 FGF2 FGF2 GPC3 GPC3 SEC61A1 SEC61A1 GREB1L GREB1L ENSPTRP00000069764 ENSPTRP00000069764 TEK TEK SIX1 SIX1 ASXL1 ASXL1 PODXL PODXL SULF1 SULF1 POU3F3 POU3F3 FGF8 FGF8 SHH SHH ENPEP ENPEP NPHS1 NPHS1 PBX1 PBX1 WNT9B WNT9B PGF PGF HOXD11 HOXD11 PLCE1 PLCE1 LHX1 LHX1 FOXC2 FOXC2 KIF26B KIF26B COL4A4 COL4A4 GDNF GDNF NUP160 NUP160 WWTR1 WWTR1 CTNNB1 CTNNB1 HS3ST3B1 HS3ST3B1 HES5 HES5 CITED1 CITED1 NOTCH1 NOTCH1 COMMD5 COMMD5 EXT1 EXT1 CALB1 CALB1 EYA1 EYA1 ANGPT2 ANGPT2 SMO SMO MAGI2 MAGI2 GLI3 GLI3 ENSPTRP00000075757 ENSPTRP00000075757 ENSPTRP00000075771 ENSPTRP00000075771 NOTCH2 NOTCH2 WNT9B-2 WNT9B-2 UMOD UMOD ENSPTRP00000077262 ENSPTRP00000077262 TFAP2B TFAP2B PTPRO PTPRO CTNNBIP1 CTNNBIP1 HS2ST1 HS2ST1 WNT6 WNT6 GPR4 GPR4 PDGFRB PDGFRB LOC107968591 LOC107968591 HES5-2 HES5-2 BMP4-2 BMP4-2 PECAM1 PECAM1 SULF2 SULF2 CD24 CD24 HNF1B HNF1B LZTS2 LZTS2 KIRREL3 KIRREL3 MTSS1 MTSS1 CK820_G0054628 CK820_G0054628 EGR1 EGR1 PAX8 PAX8 NPNT NPNT HS3ST3A1 HS3ST3A1 PTCH1 PTCH1 WT1 WT1 CK820_G0034767 CK820_G0034767 DCHS1 DCHS1 HEYL HEYL BCL2 BCL2 AQP1 AQP1 HOXA11 HOXA11 DLL1 DLL1 AHI1 AHI1 TCF21 TCF21 FGF1 FGF1 KLHL3 KLHL3 ADAMTS16 ADAMTS16 IRX1 IRX1 IRX2 IRX2 DCHS2 DCHS2 EDNRA EDNRA PKD2 PKD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMA5Laminin, alpha 5. (2203 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PAX2PAX2 isoform 1. (417 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
FOXD1FOXD1 isoform 1. (439 aa)
LGR4LGR4 isoform 2. (951 aa)
PROM1PROM1 isoform 12. (865 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
SIX2SIX homeobox 2. (291 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TMEM59LTransmembrane protein 59-like. (343 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
WNK4WNK lysine deficient protein kinase 4. (1282 aa)
IRX3Iroquois homeobox 3. (500 aa)
SOX8SOX8 isoform 1. (446 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NID1NID1 isoform 2. (1247 aa)
NUP133NUP133 isoform 1. (1156 aa)
CD34CD34 isoform 1. (328 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FMN1FMN1 isoform 1. (1425 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (642 aa)
SALL1SALL1 isoform 2. (1326 aa)
KLF15Kruppel-like factor 15. (416 aa)
GATA3GATA binding protein 3. (444 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
FOXC1FOXC1 isoform 1. (550 aa)
ILKIntegrin-linked kinase. (533 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
BASP1Brain abundant, membrane attached signal protein 1. (226 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
ENSPTRP00000069764annotation not available (1213 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
SIX1SIX homeobox 1. (284 aa)
ASXL1ASXL transcriptional regulator 1. (1548 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
POU3F3POU domain protein. (476 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENPEPAminopeptidase. (979 aa)
NPHS1NPHS1 isoform 1. (1241 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
HOXD11HOXD11 isoform 2. (339 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
KIF26BKIF26B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
COL4A4COL4A4 isoform 1. (1690 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
NUP160NUP160 isoform 2. (1436 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
COMMD5COMM domain containing 5. (224 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CALB1CALB1 isoform 3. (261 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
ENSPTRP00000075757annotation not available (495 aa)
ENSPTRP00000075771COMM domain-containing protein 5. (229 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
UMODUMOD isoform 1. (690 aa)
ENSPTRP00000077262annotation not available (314 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
HS2ST1T0142978 isoform 1. (356 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LOC107968591CD24 isoform 1. (80 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
PECAM1Platelet/endothelial cell adhesion molecule. (745 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
CD24CD24 isoform 8. (129 aa)
HNF1BHNF1 homeobox B. (557 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (787 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PAX8PAX8 isoform 1. (456 aa)
NPNTNPNT isoform 10. (611 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (374 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
WT1WT1 transcription factor. (514 aa)
CK820_G0034767SEC61A2 isoform 11; Belongs to the SecY/SEC61-alpha family. (136 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
HOXA11HOXA11 isoform 2. (313 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
AHI1Abelson helper integration site 1. (1196 aa)
TCF21Transcription factor 21. (179 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KLHL3Kelch like family member 3. (608 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
IRX1Iroquois homeobox 1. (480 aa)
IRX2Iroquois homeobox 2. (471 aa)
DCHS2DCHS2 isoform 3. (2915 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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