STRINGSTRING
SIX2 SIX2 BMP4 BMP4 SMAD4 SMAD4 OSR1 OSR1 BMP7 BMP7 PKD2 PKD2 TCF21 TCF21 SIX4 SIX4 AMER1 AMER1 WNT4 WNT4 BASP1 BASP1 SIX1 SIX1 SHH SHH PDGFRB PDGFRB BMP4-2 BMP4-2 WT1 WT1 STAT1 STAT1 PAX2 PAX2 FOXD1 FOXD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX2SIX homeobox 2. (291 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
TCF21Transcription factor 21. (179 aa)
SIX4SIX homeobox 4. (781 aa)
AMER1APC membrane recruitment protein 1. (805 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BASP1Brain abundant, membrane attached signal protein 1. (226 aa)
SIX1SIX homeobox 1. (284 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
WT1WT1 transcription factor. (514 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PAX2PAX2 isoform 1. (417 aa)
FOXD1FOXD1 isoform 1. (439 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.